期刊
MOLECULES
卷 21, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/molecules21060815
关键词
Aza-Michael reactions; mono-addition; acidic alumina; solvent-free; primary amines
资金
- University of Malta
- project: Strengthening of the Organic, Inorganic, Physical Chemistry Facilities [309]
- project: Strengthening of Analytical Chemistry, Biomedical Engineering and Electromagnetics RTDI Facilities [018]
Aza-Michael reactions between primary aliphatic and aromatic amines and various Michael acceptors have been performed under environmentally-friendly solventless conditions using acidic alumina as a heterogeneous catalyst to selectively obtain the corresponding mono-adducts in high yields. Ethyl acrylate was the main acceptor used, although others such as acrylonitrile, methyl acrylate and acrylamide were also utilized successfully. Bi-functional amines also gave the mono-adducts in good to excellent yields. Such compounds can serve as intermediates for the synthesis of anti-cancer and antibiotic drugs.
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