期刊
MOLECULES
卷 21, 期 8, 页码 -出版社
MDPI AG
DOI: 10.3390/molecules21080970
关键词
mangrove actinomycetes; Streptomyces sp 219807; elaiophylin; cytotoxic
资金
- EU FP7 project PharmaSea [312184]
- China 973 program [2012CB721001]
During our search for interesting bioactive secondary metabolites from mangrove actinomycetes, the strain Streptomyces sp. 219807 which produced a high elaiophylin yield of 4486 mg/L was obtained. A new elaiophylin derivative, halichoblelide D (1), along with seven known analogues 2-8 was isolated and identified from the culture broth. Their chemical structures were determined by detailed analysis of 1D and 2D NMR and HRMS data. The absolute configuration of halichoblelide D (1) was confirmed by comparing the CD spectrum with those of the reported analogues. Compounds 1-7 exhibited potent cytotoxic activities against HeLa and MCF-7 cells with IC50 values ranging from 0.19 to 2.12 mu M.
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