期刊
MOLECULES
卷 21, 期 9, 页码 -出版社
MDPI AG
DOI: 10.3390/molecules21091149
关键词
nanocrystals; nanosuspensions; panax notoginseng saponins; redispersibility; freeze-drying; spray-drying
资金
- Scientific Research Foundation for the National Natural Science of China [81560656]
- Fund of distinguished young scientists of Jiangxi Province
- Natural Science Fund of Jiangxi Province [20161BAB205221]
This study is aimed at seeking a nature saponin-based stabilizer for drug nanosuspensions. A poorly soluble drug (baicalein, BCL) was used as a model drug. BCL nanosuspensions with particle size of 156 nm were prepared by means of homogenization and converted into BCL nanocrystals (BCL-NC) stabilized with panax notoginseng saponins (PNS). It was found that PNS was able to prevent the aggregation of BCL-NS during storage and improve the redispersibility of BCL-NC after freeze-drying and spray-drying, compared with polymer stabilizer PVPK30. The freeze-dried and spray-dried BCL-NC with PNS exhibited excellent performance as evidenced by scanning_electron_microscope (SEM) analysis. It was the reason that PNS possessed the interfacial property (41.69 +/- 0.32 mN/m) and electrostatic effect (-40.1 +/- 1.6 mV), which could easily adsorb onto the surface of hydrophobic BCL nanocrystals and prevent from its aggregation. It is concluded that PNS can be used as an effective nature stabilizer for production of drug nanocrystals.
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