期刊
MOLECULES
卷 21, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/molecules21070844
关键词
analgesia; capsaicinoids; chili peppers; desensitization; TRPV1
资金
- Coordenadoria de Aperfeicoamento de Pessoal de Nivel Superior (CAPES, Brazil)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, Brazil)
- Ministerio da Ciencia, Tecnologia e Inovacao (MCTI)
- Secretaria da Ciencia, Tecnologia e Ensino Superior (SETI)/Fundacao Araucaria and Governo do Estado do Parana (Brazil)
In this review, we discuss the importance of capsaicin to the current understanding of neuronal modulation of pain and explore the mechanisms of capsaicin-induced pain. We will focus on the analgesic effects of capsaicin and its clinical applicability in treating pain. Furthermore, we will draw attention to the rationale for other clinical therapeutic uses and implications of capsaicin in diseases such as obesity, diabetes, cardiovascular conditions, cancer, airway diseases, itch, gastric, and urological disorders.
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