期刊
MOLECULES
卷 21, 期 12, 页码 -出版社
MDPI AG
DOI: 10.3390/molecules21121684
关键词
benzofuran; N-aryl piperazine moiety; anti-inflammatory activity; anticancer activity
资金
- Natural Science Foundation of China [81460624, 81560620]
- Application Basic Research Program of Yunnan Province [2014FZ078, 2014FZ087]
- Yunnan Province doctoral newcomer Award [YN2015015]
- Key Discipline of Pharmacy and Yi medicine (Yunnan University of Traditional Chinese Medicine, China)
A series of novel hybrid compounds between benzofuran and N-aryl piperazine have been synthesized and screened in vitro for anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated RAW-264.7 macrophages and for anticancer activity against three human tumor cell lines. The results demonstrated that derivative 16 not only had inhibitory effect on the generation of NO (IC50 = 5.28 mu M), but also showed satisfactory and selective cytotoxic activity against human lung cancer line (A549) and gastric cancer cell (SGC7901) (IC50 = 0.12 mu M and 2.75 04, respectively), which was identified as the most potent anti-inflammatory and anti-tumor agent in this study.
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