相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review
Biotechnology & Applied Microbiology
Baodong Hu et al.
Summary: Natural products are structurally diverse molecules with a wide range of biological activities. Cytochrome P450 enzymes are involved in the biosynthesis of many natural products and recent research has provided new insights for their application in the biosynthesis of natural products.
CRITICAL REVIEWS IN BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Santosh Kumar Vishwakarma et al.
Summary: In this study, nine PAL genes were identified from three orchid species, and differential expression patterns were found in different tissues. Furthermore, the functional characterization of PAL genes can be utilized in the genetic improvement of medicinal orchids.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Multidisciplinary Sciences
Ricardo De La Pena et al.
Summary: Triterpenes with complex scaffold modifications are common in plants, and limonoids are a well-known family responsible for the bitter taste in citrus and the active constituents of neem oil. However, the complete biosynthetic route of limonoids has not been described. This study discovered 22 enzymes involved in the biosynthesis of important limonoids and provided a template for the discovery and reconstitution of triterpene biosynthetic pathways in plants.
Article
Biodiversity Conservation
Yuming Sun et al.
Summary: Plant secondary metabolites play crucial roles in plant-environment interactions and are greatly affected by global climate changes. Our meta-analysis study on medicinal and aromatic plants showed that phenolic and terpenoid levels generally respond positively to elevated carbon dioxide (eCO(2)) but negatively to elevated nitrogen deposition (eN), while total alkaloid concentration increases with eN. Decreased precipitation (dP) promotes the levels of all secondary metabolites, while elevated temperature (eT) positively influences the levels of phenolic compounds. The responses of secondary metabolites to climate changes are moderated by plant functional types, climate change levels, mean annual temperature, and mean annual precipitation. Plant phenolic and terpenoid responses to climate changes can be attributed to variations in carbon to nitrogen ratio and total soluble sugar levels.
GLOBAL CHANGE BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chao Feng et al.
Summary: In this study, the phylogeny and genomic characteristics of introgression in wild diploid strawberries were investigated. It was found that regions with low recombination played a crucial role in hybridization and contributed to the construction of the species tree. Complex and widespread introgression was revealed across the genus Fragaria, with an average proportion of approximately 4.1% of the extant genome. Additionally, selective sweeps on four SLF genes were identified, suggesting their potential roles in the regain of self-incompatibility through ancient introgression.
MOLECULAR BIOLOGY AND EVOLUTION
(2023)
Review
Engineering, Chemical
Yaxuan Wang et al.
Summary: Signaling molecules play a crucial role in connecting endophytes and host plants. They are involved in the recognition of endophytes, regulation of host plant growth and development, and synthesis of secondary metabolites. This review provides an overview of the types and characteristics of signaling molecules in medicinal plants, as well as the intracellular conduction and multi-molecular crosstalk of signaling molecules during interactions between endophytic bacteria and medicinal plants. It also summarizes the molecular mechanisms of signal molecules in the accumulation and regulation of medical metabolites. This work serves as a reference for utilizing endophytic bacteria and medicinal plants to synthesize pharmaceutical active ingredients in a bioreactor.
Article
Plant Sciences
Bin Yu et al.
Summary: Photoperiod plays a prominent role in seed development by controlling seed size in different plant species. The central regulator CONSTANS directly represses the transcription of AP2, thereby modulating seed size in a photoperiod-dependent manner.
Article
Biochemistry & Molecular Biology
Priya Shree et al.
Summary: By utilizing molecular docking and molecular dynamics simulation, this study identifies potential phytochemicals from medicinal plants that could inhibit SARS-CoV-2 and possess drug-like properties.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Plant Sciences
Chuanyong Xiong et al.
Summary: This study found that cluster-root formation in white lupin under phosphorus deficiency is regulated by flavonoids. Phosphorus deficiency induces flavonoid accumulation and promotes cluster-root development by modulating auxin response.
Article
Virology
Muhammad Shahzad et al.
Summary: This study explores the anti-HIV potential of various medicinal plant extracts and finds that they inhibit HIV replication in vitro with low cytotoxicity. These natural extracts have the potential to become complementary and alternative medicine for HIV infection.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Asim Najmi et al.
Summary: Natural products are an important source of new lead compounds in drug discovery research, especially those derived from plants. Despite pharmaceutical companies' lack of attention to natural product drug discovery, recent technological advancements have revived scientific interest. This review provides a comprehensive overview of the various approaches used in selecting, authenticating, extracting/isolating, screening, and developing natural products, with a focus on bioactivity-guided fractionation. The integration of interdisciplinary approaches, technological advances, and new methods holds great potential for the future development of therapeutic drugs.
Article
Biochemistry & Molecular Biology
Desnor N. Chigumba et al.
Summary: This study reveals the biosynthetic mechanism of plant cyclic peptides and identifies five classes of plant RiPP derived from BURP domains, laying the foundation for further exploration of plant RiPP natural products.
NATURE CHEMICAL BIOLOGY
(2022)
Article
Plant Sciences
Wende Deng et al.
Summary: This study found that dendrobine can alleviate inflammatory osteolysis by inhibiting osteoclastogenesis and bone resorption. In vitro experiments showed that dendrobine exerted its effects by suppressing ROS, p38-c-Fos, and NFATc1-MMP9. In vivo experiments showed that oral administration of dendrobine prevented LPS-induced osteolysis.
Article
Plant Sciences
Qian Qiao et al.
Summary: This study analyzed the differential gene expression associated with different leaf colors and growth stages in Acer truncatum varieties using transcriptome sequencing and flavonoid metabolism. The study also explored the relationships between gene expression and flavonoid and anthocyanin contents, aiming to improve the ornamental value and develop flavonoid-rich A. truncatum. The findings shed light on the key genes involved in breeding red A. truncatum and varieties with high flavonoid content.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Integrative & Complementary Medicine
Rongrong Zhang et al.
Summary: This study analyzed the active ingredients of CTCMDO and established its fingerprint. It was found that CTCMDO could suppress itch behavior in a dose-dependent manner and improve AD by inhibiting the production of cytokines, reversing the upregulation of itch-related genes, and suppressing the phosphorylation of certain protein kinases.
Article
Plant Sciences
Jiajing Chen et al.
Summary: This study demonstrated that ectopic expression of the MdBBM1 gene dramatically increased the efficiency of transgenic apple plant production. It provided a solution for overcoming the barriers to transgenic plant production in apple and possibly in other trees.
HORTICULTURE RESEARCH
(2022)
Article
Multidisciplinary Sciences
Jiaxuan Xia et al.
Summary: The limited capturing efficiency of circulating tumor cells (CTCs) and the lack of regulation capability on CTC-supportive metastatic niches (MNs) are two main obstacles for the clinical translation of conventional liposomes in treating metastatic breast cancers. A multifunctional Rg3 liposome loaded with docetaxel (Rg3-Lp/DTX) was developed, which exhibited higher CTC-capturing efficiency through interaction with glucose transporter 1 (Glut1) and inhibited the formation of MNs by reversing the immunosuppressive microenvironment. This strategy has great clinical translation prospects for antimetastasis treatment with enhanced therapeutic efficacy and a simple preparation process.
Review
Plant Sciences
Ying Li et al.
Summary: P-type and V-type H+-ATPases are important ATP-driven proton pumps that play distinct roles in plant growth and stress adaptation, regulated by hormones and environmental cues. Understanding their regulatory mechanisms provides new perspectives for improving plant growth and stress tolerance.
ANNUAL REVIEW OF PLANT BIOLOGY
(2022)
Article
Plant Sciences
Na Lin et al.
Summary: By studying the yellow leaf mutant of Brassica napus, it was found that the mutant had significantly reduced chlorophyll content and photosynthetic efficiency, as well as abnormal chloroplast morphology. Mapping and validating the mutant gene will facilitate the cloning of related genes and provide more genetic and physiological information about chloroplast development in Brassica napus.
Article
Biochemistry & Molecular Biology
Yu Qin et al.
Summary: Drought is a key threat to plants and agriculture, and the role of the enzyme phenylalanine ammonia lyase (PAL) in drought tolerance has been explored in this study. A PAL member called FuPAL1 was isolated from the alpine pharmaceutical plant Fritillaria unibracteata. FuPAL1 was found to play a role in the ammonization process and was involved in substrate binding and catalysis. Transgenic Arabidopsis plants with FuPAL1 showed increased levels of lignin and salicylic acid and enhanced drought tolerance. These findings suggest that FuPAL1 could be a valuable target for improving drought resistance.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Laura Ceballos-Laita et al.
Summary: Iron and manganese are essential elements for plants, but they compete for the same uptake transporters and show conflicting interactions at the regulatory level. Proteomic techniques were used to study the proteome profiles of tomato roots grown under iron or manganese deficiency. The results showed that both deficiencies led to common cell wall remodelling, but differed greatly in terms of oxidative stress, coumarin production, protein, nitrogen, and energy metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Multidisciplinary
Hossein Hazrati et al.
Summary: In this study, the effects of different levels of competition on the metabolome of rye plants were examined. The results showed that high competition reduced the concentration of BXs and increased the levels of other compounds in rye roots, indicating the plants' ability to enhance their defense mechanisms under induced stress. These findings contribute to a better understanding of the biochemical response of plant species to competition.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Jiehua Qiu et al.
Summary: Changes in global temperatures have a significant impact on the occurrence of plant diseases. This study reveals the molecular mechanism behind the epidemic of rice blast at warm temperatures, showing that reduced JA biosynthesis and signaling enhance the susceptibility to Magnaporthe oryzae infection.
Article
Biochemistry & Molecular Biology
Yongjing Yang et al.
Summary: The study extracted and isolated a homogenous acidic polysaccharide, RPP-2a, from raspberry pulp, which exhibited immunomodulatory effects by activating macrophages and enhancing immune function. RPP-2a has a high molecular weight and consists of various sugar moieties, making it a potential natural immune-enhancing agent.
Article
Biochemistry & Molecular Biology
Shun Peng et al.
Summary: CPR5 is an RNA-binding protein that modulates plant immunity by interacting with RNA processing complexes. It functions together with the NineTeen Complex and CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR to activate plant immunity. CPR5 belongs to the Transformer 2 (Tra2) subfamily of RNA-binding proteins and is localized in nuclear speckles. It binds to RNA sequences targeted by Tra2 proteins and is involved in alternative splicing of CPR5-regulated genes.
Article
Plant Sciences
Wancong Yu et al.
Summary: The transcription of GhAG2 was significantly enhanced by glyphosate treatment, and overexpression of GhAG2 in transgenic plants improved salt and salicylic acid stress tolerance. The study identified differentially expressed genes in response to glyphosate treatment and highlighted the potential of GhAG2 in enhancing stress tolerance in crops. The results provide insights into glyphosate-induced transcriptional changes, potential applications of GhAG2 in crop improvement, and the development of a glyphosate-inducible gene expression system in plants.
PLANT CELL REPORTS
(2022)
Article
Plant Sciences
Zhixin Liu et al.
Summary: In this study, we comprehensively characterized the early differentiation and development of leaf veins in 3-day-old cotyledons based on single-cell transcriptome analysis. We identified the cell types and novel marker genes of leaf veins and characterized the novel regulators of leaf vein.
Article
Plant Sciences
Zhen Liu et al.
Summary: This study cloned a CHS gene from trifoliate orange and analyzed its biological information and partial functions. PtCHS was found to be highly expressed in stems, leaves and flowers, but lowly expressed in roots and seeds. Soil water deficit up-regulated expressions of PtCHS in leaves. An arbuscular mycorrhizal fungus significantly increased plant biomass production, CHS activity, expressions of PtCHS, and total flavonoid content in leaves and roots, independent of soil water status.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Lu Yao et al.
Summary: In this study, we developed a multi-modular strategy to enhance the yield of ginsenoside Rg(3) in Panax ginseng. By improving the enzymatic efficiency and metabolic flux, we successfully increased the accumulation of ginsenoside Rg(3). The established high-production system could potentially be used for commercial production of ginsenoside Rg(3) for pharmaceutical purposes.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Benke Hong et al.
Summary: Strychnine, a natural product with potent neurotoxicity, is currently used as a pesticide. Its complex polycyclic structure has inspired chemists to develop new synthetic methods. This study reveals the biosynthetic pathway of strychnine, along with related compounds brucine and diaboline, and successfully demonstrates the synthesis of these compounds in Nicotiana benthamiana through metabolic engineering.
Review
Cell Biology
Ron Mittler et al.
Summary: This review discusses the essential role of reactive oxygen species (ROS) in plant responses to abiotic and biotic stresses, as well as the mechanisms of ROS signaling, regulation, and resilience in plants.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2022)
Article
Plant Sciences
Tsubasa Shoji et al.
Summary: In this study, the researchers investigated the regulation of nicotine biosynthesis in tobacco and identified several low-nicotine tobacco varieties lacking specific transcription factors. They characterized the newly identified alleles and examined their influence on alkaloid contents and gene expression related to nicotine biosynthesis. They also demonstrated the effect of a distal genomic region deletion on the expression of a key transcription factor and the alkaloid phenotype. These findings provide new insights into the regulation of nicotine biosynthesis and offer genetic resources for breeding low-nicotine tobacco.
Article
Multidisciplinary Sciences
Keji Yu et al.
Summary: The study demonstrates the involvement of ascorbate-linked flavan-3-ol oligomers in the extension of proanthocyanidins. These novel intermediates, termed sub-PAs, provide new insights into the mechanism of PA oligomerization.
NATURE COMMUNICATIONS
(2022)
Article
Plant Sciences
Pengfei Hao et al.
Summary: In this study, the metabolites and genes involved in red pigment formation in rapeseed petals were identified. Flavonoids, especially anthocyanins, were found to play an important role in red pigment formation, and BnaA03.ANS was identified as an irreplaceable gene in red-flowered rapeseed.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Genetics & Heredity
Rakesh Singh et al.
Summary: In this study, a transcriptome database for Tinospora cordifolia was constructed, providing information on transcripts and transcription factors. This database will address the lack of genomic resources for T. cordifolia and facilitate molecular breeding and related research for genetic improvement.
Review
Plant Sciences
Yuantao Xu et al.
Summary: Apomixis is a clonal reproduction phenomenon by seed, with potential applications in genotype fixation and agricultural breeding strategies. The introduction of apomixis to major crops would bring benefits, but there are challenges to its application in crops.
HORTICULTURE RESEARCH
(2022)
Article
Chemistry, Applied
Jie Meng et al.
Summary: The phenylpropane pathway (PPP) is a significant metabolic route that can impact the flavor, taste and nutrients of food. By designing a structural periodic table and using liquid chromatography tandem triple quadrupole mass spectrometry, the qualitative and quantitative analysis of 103 metabolites produced from PPP has been achieved, providing valuable insights for studying the metabolic balance of PPP and its practical application.
Letter
Plant Sciences
Xiaojun Su et al.
HORTICULTURE RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Sasilada Sirirungruang et al.
Summary: Plants are a unique source of specialized metabolites, but their availability fails to meet the current demands. This article explores plant engineering as a complementary path to expand the production capacity of target plant molecules, highlighting emerging engineering tools and scientific advances.
NATURAL PRODUCT REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Nan Qiu et al.
Summary: Protein S-palmitoylation is crucial in cancer cells, and artemisinin, a clinically approved antimalarial drug, has been found to inhibit a specific palmitoyl transferase, reducing palmitoylation of oncogenic proteins and disrupting cell proliferation signaling cascades.
CELL CHEMICAL BIOLOGY
(2022)
Article
Plant Sciences
Pui Ying Lam et al.
Summary: This study investigates the formation of tricin-incorporated lignin and its effects on cell wall properties in rice mutants deficient in early flavonoid biosynthetic genes. The results show that the mutants lacking CHS, CHI, and CHIL are depleted of extractable flavones and tricin-lignin in the cell walls. However, the cell wall saccharification efficiencies of these mutants are similar to that of the wild-type controls, suggesting the complex metabolic consequences of tricin pathway perturbations and the relationship between lignin profiles and cell wall properties.
Article
Plant Sciences
Xu Zeng et al.
Summary: Codonopsis pilosula, a traditional Chinese medicinal plant, has been used for centuries to treat various ailments. While the roots of C. pilosula are considered medicinal, the aerial parts are often discarded. However, studies have shown that the stems and leaves of C. pilosula also contain active metabolites. Analyzing the waste products from the leaves and stems, researchers identified numerous differentially expressed metabolites, indicating the potential value of utilizing these parts of the plant.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Mingjun Gao et al.
Summary: The discovery of a conserved immune suppression network in cereals centered on the Ca2+-sensor ROD1 is significant in understanding how plants fine-tune immune homeostasis. ROD1 promotes reactive oxygen species scavenging and its disruption confers resistance to multiple pathogens. The fungal effector AvrPiz-t structurally mimics ROD1 to suppress host immunity and promote virulence, revealing a molecular framework for breeding disease-resistant, high-yield crops.
Article
Chemistry, Applied
Rocio Galindo-Lujan et al.
Summary: This study analyzed the proteins from different varieties of quinoa seeds from Peru and Bolivia using advanced LC-MS/MS technology, identifying protein similarities and differences in the proteome. The comprehensive experimental quinoa seed proteome map presented in this study serves as a valuable starting point for further characterization and nutritional studies of quinoa and quinoa-containing food products.
Review
Biochemistry & Molecular Biology
Qinling Zhong et al.
Summary: Salicylic acid (SA) is a key plant hormone in defense against pathogen infection, predominantly synthesized from isochorismate in Arabidopsis. Recent studies have shed light on how SA regulates plant growth by crosstalk with the growth-promoting hormone auxin, affecting defense and growth balance. Further understanding of SA biosynthesis and its role in defense and growth will be crucial for improving crop disease resistance and fitness.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Xiaomin Chen et al.
Summary: Jiaocheng kucha flowers contain theacrine, with the highest content being in the flower bud stage. Differentially expressed genes related to theacrine synthesis were identified, indicating that ADSL and UAZ may play key roles in regulating the metabolism of theacrine in the flowers of Jiaocheng kucha.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Li Pei et al.
Summary: The study presents the de novo assembly and genomic analysis of the Opium poppy traditional landrace 'Chinese Herbal Medicine', comparing it with a previously sequenced variety. Through comparative analysis, it was found that opium poppy underwent two whole-genome duplication events, which led to gene family expansions related to characteristic secondary metabolite production and disease resistance. Genomic and transcriptomic analyses identified genes associated with agronomically different phenotypes, providing valuable resources for future basic and agricultural studies of the opium poppy.
HORTICULTURE RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Yueyue Wang et al.
Summary: The 2-oxoglutarate-dependent dioxygenase (2-OGD) superfamily is one of the largest protein families in plants, and its members mainly catalyze the metabolism of flavonoids in plants. Different enzymes play their respective dominant roles in the flavonoid metabolic pathway, despite the presence of functional redundancy among them.
Article
Biochemistry & Molecular Biology
Xiaozhen Huang et al.
Summary: The study reveals that H2O2 in plant shoot apical meristem triggers reversible protein phase separation of TMF, a transcription factor that controls flowering transition in tomatoes. This process involves oxidation-regulated disulfide bonds formation within TMF, allowing it to bind and repress the expression of floral identity genes, providing aerobic organisms with flexibility in gene control in response to developmental cues.
NATURE CHEMICAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Teng-Kuei Huang et al.
Summary: Nicotiana tabacum, a non-food herb, shows potential as a bio-factory for producing medicines, vaccines, or valuable metabolites, but improving genetic tools for targeted genome modifications is crucial. By replacing SpCas9 with other CRISPR/Cas-based nucleases like SaCas9 and ttLbCas12a, targeting the tobacco SuRB gene showed improved efficiencies, suggesting ttLbCas12a as a superior alternative for gene editing in tobacco and other crops.
PLANT BIOTECHNOLOGY JOURNAL
(2021)
Review
Plant Sciences
Yujun Peng et al.
Summary: Salicylic acid (SA) serves as a crucial plant defense hormone, playing essential roles in plant immunity against pathogens. Significant progress has been made in understanding the biosynthesis, perception, and receptor regulation of SA in recent years, but there are still key questions that need to be addressed in SA biosynthesis and signaling.
ANNUAL REVIEW OF PLANT BIOLOGY, VOL 72, 2021
(2021)
Article
Plant Sciences
Laura Montesinos et al.
Summary: The hybrid peptide BP178, engineered for plant expression, exhibits strong bactericidal activity and induces plant defense responses in tomato plants, enhancing their resistance against pathogenic bacteria. The upregulated genes include pathogenesis-related proteins and transcription factors involved in signaling pathways, suggesting that BP178 acts through a dual mechanism of antimicrobial activity and plant defense elicitation.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Plant Sciences
Mohamed Ayash et al.
Summary: The plant nucleus, despite its importance in genetic information and gene expression, has been understudied. In this study, nuclear proteome fractions from Arabidopsis thaliana cells treated with two elicitors of plant immunity were analyzed. The research revealed potential nuclear protein import upon elicitation of immunity and changes in protein abundance in the nucleus related to plant immunity processes. Promiscuous ribosome assembly and the role of prohibitins and cytochrome C in plant immune responses were also highlighted.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Plant Sciences
Qi Tang et al.
Summary: The study utilized two different transcriptome sequencing platforms to investigate the flavonoid synthetic pathways in blueberries, identifying a transcription factor VcMYB1 that positively regulates anthocyanin synthesis. This provides background information and data for studying the synthetic pathways of flavonoids and other secondary metabolites in blueberries.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Plant Sciences
Xia Chen et al.
Summary: This study demonstrates the superiority of cassava sexual tetraploids in plant height, biomass, yield, and starch accumulation, possibly due to enriched flavonoid biosynthesis and glycolysis/gluconeogenesis pathways providing resistance and better yield, respectively.
Review
Pharmacology & Pharmacy
Kenneth B. Walsh et al.
Summary: The medicinal use of cannabis has a long history, with recent breakthroughs in understanding the pharmacology of minor cannabinoids showing potential therapeutic benefits in the treatment of various conditions. Although studies demonstrate their agonist and antagonist activities at multiple targets, further research is needed to fully understand their pharmacological mechanisms.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Mehmet Boga et al.
Summary: The study investigated the phytochemical profiles of Hypericum empetrifolium extracts from aerial parts and roots, revealing the presence of various compounds with antioxidant and antimicrobial activities. The aerial parts extract demonstrated significant antioxidant effects and antimicrobial activity, while the roots extract showed strong inhibitory effects on cholinesterase enzymes. Further research is needed to explore additional therapeutic properties of this plant.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Mingxu Zhang et al.
Summary: Due to modern developments in the traditional medicine industry, more people now acknowledge the efficacy of traditional medicine and the demand for herbal medicines is gradually increasing. Different countries and regions have formulated relevant standards to regulate the cultivation of local herbs to ensure product safety and reliability, but the differences in standards hinder the international trade of herbal medicines.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Chemistry, Medicinal
Bhawna Chopra et al.
Summary: Natural products have been used in folklore for centuries for treating various ailments, with plant-derived products recognized as a source of therapeutic agents and structural diversity. After small modifications, natural molecules can offer better pharmacological potential as new molecular entities.
PHYTOTHERAPY RESEARCH
(2021)
Article
Plant Sciences
Andrea Laura Venturuzzi et al.
Summary: The study highlights the importance of the salicylic acid (SA) immune pathway in influencing the long-distance transport of Tobacco Mosaic Virus (TMV), through negative regulation of NPR1 and TGA10 factors. Furthermore, the stabilization of DELLA proteins by the capsid protein (CP) also plays a role in promoting the systemic movement of TMV.
Article
Immunology
Ricardo Salomon et al.
Summary: The study showed that the inclusion of medicinal plant leaf extract from sage and lemon verbena in the diet of gilthead seabream had beneficial effects on gut health, supporting gut homeostasis and increasing the integrity of the intestinal epithelium.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Plant Sciences
Cong Li et al.
Summary: The study investigated the role of JA in enhancing D. catenatum resistance to S. delphinii, showing that exogenous MeJA changed the expression of most core JA pathway genes and key members like DcJAZ1/2/5 and DcMYC2b are involved in enhancing defense ability to S. delphinii in D. catenatum.
Article
Genetics & Heredity
Kenta Shirasawa et al.
Summary: This study determined and analyzed the whole-genome sequences of two Rhododendron species to enhance the genomics and genetics of azalea. Different sequencing technologies were used to construct the genome sequence assemblies of R. ripense and R. kiyosumense, predicting a large number of genes and helping to reveal the phylogenetic relationships between closely related species.
Review
Chemistry, Applied
Manoj Kumar et al.
Summary: Phenolic compounds from plant sources have significant health-promoting properties and are known to alleviate the risk of various lifestyle diseases, therefore, exploring plant-based phenolic compounds and efficient extraction technologies is crucial. Some important sources of bioactive phenolic compounds and novel extraction technologies have been highlighted in this review.
Article
Biochemistry & Molecular Biology
Yuru Tong et al.
Summary: Acyclic terpenes, commonly found in plants, are controlled by different terpene synthases. The study found that terpene synthases from Tripterygium wilfordii exhibited substrate promiscuity and key residues were identified for the generation of diterpene product. Additionally, an engineered yeast producing high levels of nerolidol was constructed for potential applications in microbial fermentation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Plant Sciences
Joseph B. Lambert et al.
Summary: The class of plant exudates containing the phenol functionality, known as phenolics, was defined, surveyed, and characterized using solid-state C-13 NMR spectroscopy and solution-state H-1 NMR spectroscopy. Subclasses were identified based on the similarity of their C-13 spectra, including aloetics, guaiacs, xanthics, and kinos. Phenolic exudates are often mixed with terpenoid and carbohydrate materials to form hybrid subgroups.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Plant Sciences
Feng Zhu et al.
Summary: The study shows that glutathione (GSH) plays a crucial role in the local and systemic resistance of Nicotiana benthamiana to Tobacco mosaic virus (TMV), through differential modulation of salicylic acid (SA) and reactive oxygen species (ROS).
MOLECULAR PLANT PATHOLOGY
(2021)
Article
Biochemical Research Methods
Javier Antonio Alfaro et al.
Summary: Single-cell profiling methods have greatly impacted the understanding of cellular heterogeneity, although proteome profiling at the single-cell level is still in the early stages. The development of new technologies, such as single-molecule protein sequencing and innovations in mass spectrometry, will eventually enable broad sequence coverage in single-cell proteomics, leading to new biological discoveries and opportunities for ultra-sensitive disease diagnostics.
Article
Multidisciplinary Sciences
Yifei Liu et al.
Summary: Chinese goldthread (Coptis chinensis) is an early-diverging eudicot plant with diverse medicinal applications. The high-quality genome assembly and annotation of C. chinensis revealed a single ancient whole-genome duplication event shared by the Ranunculaceae family. The study also highlighted the functional importance of CYP719 gene in diversifying protoberberine-type alkaloids.
NATURE COMMUNICATIONS
(2021)
Article
Plant Sciences
Hisashi Udagawa et al.
Summary: In this study, a whole-exome sequencing (WES) procedure was developed in tobacco to characterize EMS-induced mutations in a test population, revealing a high number of single nucleotide variants. The amount of mutations detected by WES was 93.5% of those detected by whole-genome sequencing, while requiring significantly less sequencing data, making it a cost-effective tool for high-throughput mutation identification in tobacco.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Medicine, Research & Experimental
Ying Huang et al.
Summary: The study confirmed Tanshinone I as a novel EZH2 inhibitor that regulates normal and malignant hematopoiesis, and identified MMP9 and ABCG2 as potential therapeutic targets for myeloid malignant diseases.
Article
Plant Sciences
Xingyao Xiong et al.
Summary: This study completed the chromosome-level genome sequencing of Taxus, revealing its genome evolution and the biosynthesis pathways of paclitaxel and taxadiene. A unique physical and functional grouping of CYP725As for paclitaxel biosynthesis was discovered in the Taxus genome, along with a gene cluster mainly formed by gene duplications for taxadiene biosynthesis.
Article
Biology
Linhui Yu et al.
Summary: Lipids metabolism involves various reactions in different subcellular compartments, and isotopic labeling of acetate is a useful tool to study fatty acid synthesis and complex lipid metabolism in plants and other organisms.
Review
Biochemistry & Molecular Biology
Benjamin R. Lichman
Summary: Alkaloids from plants, known for their structural diversity and bioactivity, hold a privileged position in both modern and traditional medicines. Recent research has made significant progress in elucidating the biosynthetic origins of plant alkaloids. This review focuses on the metabolic origins of true alkaloids, specialized metabolites derived from amino acids with a nitrogen heterocycle, highlighting the key roles played by modifications to primary metabolism, iminium reactivity, and spontaneous reactions in the molecular and evolutionary origins of these pathways.
NATURAL PRODUCT REPORTS
(2021)
Review
Plant Sciences
Julian Garcia Bossi et al.
JOURNAL OF EXPERIMENTAL BOTANY
(2020)
Article
Plant Sciences
Carsten Gruendemann et al.
Review
Plant Sciences
Pingtao Ding et al.
TRENDS IN PLANT SCIENCE
(2020)
Article
Plant Sciences
Pornpatsorn Lertphadungkit et al.
Article
Multidisciplinary Sciences
Ryan S. Nett et al.
Article
Multidisciplinary Sciences
Wei Wang et al.
Review
Plant Sciences
Matthias Erb et al.
Article
Multidisciplinary Sciences
Prashanth Srinivasan et al.
Article
Environmental Sciences
Saham Tousi et al.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2020)
Article
Biotechnology & Applied Microbiology
Juan Zhao et al.
Article
Biotechnology & Applied Microbiology
Ah-Reum Lee et al.
METABOLIC ENGINEERING
(2019)
Review
Neurosciences
Sarah J. Tabrizi et al.
Article
Plant Sciences
Guozhong Huang et al.
Article
Biochemistry & Molecular Biology
Yi-Chen Shih et al.
Review
Cell Biology
Adrian Pickar-Oliver et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2019)
Review
Medicine, Research & Experimental
Darshana Gupta et al.
Article
Plant Sciences
Jianyu Fu et al.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2019)
Article
Plant Sciences
Ling Kui et al.
FRONTIERS IN PLANT SCIENCE
(2017)
Article
Biochemistry & Molecular Biology
Caifeng Jiao et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2016)
Article
Biochemistry & Molecular Biology
Alexandra Mueller et al.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Editorial Material
Medicine, General & Internal
Daniel R. George et al.
Article
Microbiology
Rishikesh Kumar et al.
MICROBIOLOGICAL RESEARCH
(2016)
Article
Biochemistry & Molecular Biology
Xu-Jun Zhu et al.
MOLECULAR BIOLOGY REPORTS
(2016)
Article
Multidisciplinary Sciences
Dominik Paquet et al.
Review
Pharmacology & Pharmacy
Kathleen M. Job et al.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2016)
Article
Plant Sciences
Jinjin Jiang et al.
Review
Plant Sciences
Jakub P. Piwowarski et al.
JOURNAL OF ETHNOPHARMACOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Zhiwei Huang et al.
Article
Multidisciplinary Sciences
Laura K. Henry et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Multidisciplinary Sciences
Xinyan Zhang et al.
Article
Microbiology
Alfonsus Alvin et al.
MICROBIOLOGICAL RESEARCH
(2014)
Review
Multidisciplinary Sciences
Jennifer A. Doudna et al.
Review
Biotechnology & Applied Microbiology
Ben Zhang et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2012)
Article
Plant Sciences
Yaser Mohamed Hafez et al.
Article
Plant Sciences
Lihong Li et al.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2012)
Article
Biotechnology & Applied Microbiology
Jin-Zhi Zhang et al.
Article
Multidisciplinary Sciences
Harris H. Wang et al.
Article
Plant Sciences
Kim Henrik Hebelstrup et al.
Article
Biochemical Research Methods
S Sturm et al.
JOURNAL OF CHROMATOGRAPHY A
(2006)
Article
Biotechnology & Applied Microbiology
W Wang et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2006)
Article
Biochemistry & Molecular Biology
JC Linden et al.