期刊
MOLECULES
卷 21, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/molecules21050625
关键词
low-molecular-weight fucosylated chondroitin sulfate; anti-metastasis; anti-angiogenesis; Lewis lung carcinoma; mechanism; NF-kappa B
资金
- NSFC-Shandong Joint Fund for Marine Science Research Centers [U1406402]
- National Science & Technology Support Program of China [2013BAB01B02]
- Major Science and Technology Projects of Shandong Province [2015ZDJS04002]
- Fundamental Research Funds for the Central Universities
- Taishan Scholars Project Special Funds
The low-molecular-weight fucosylated chondroitin sulfate (LFCS) was prepared from native fucosylated chondroitin sulfate (FCS), which was extracted and isolated from sea cucumber Cucumaria frondosa, and the anti-cancer mechanism of LFCS on mouse Lewis lung carcinoma (LLC) was investigated. The results showed that LFCS remarkably inhibited LLC growth and metastasis in a dose-dependent manner. LFCS induced cell cycle arrest by increasing p53/p21 expression and apoptosis through activation of caspase-3 activity in LLC cells. Meanwhile, LFCS suppressed the expression of vascular endothelial growth factor (VEGF), increased the expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) and downregulated the matrix metalloproteinases (MMPs) level. Furthermore, LFCS significantly suppressed the activation of ERK1/2/p38 MAPK/NF-kappa B pathway, which played a prime role in expression of MMPs. All of these data indicate LFCS may be used as anti-cancer drug candidates and deserve further study.
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