Modulation of carcinogenesis with selected GRAS nutraceuticals via Keap1-Nrf2 signaling pathway

Keap1-Nrf2 is a fundamental signaling cascade known to promote or prevent carcinogenesis. Extensive studies identify the key target of modulatory aspects of Keap1-Nrf2 signaling against cancer. Nutraceuticals are those dietary agents with many health benefits that have immense potential for cancer chemoprevention. The nutritional supplements known as nutraceuticals are found to be one of the most promising chemoprevention agents. Upon investigating the dual nature of Nrf2, it became clear that, in addition to shielding normal cells from numerous stresses, Nrf2 may also promote the growth of tumors. In the present review, we performed a systematic analysis of the role of 12 different nutraceuticals like curcumin, sulforaphane, resveratrol, polyunsaturated fatty acids (PUFA) from fish oil, lycopene, soybean, kaempferol, allicin, thymoquinone, quercetin, gingerol, and piperine in modulating the Nrf2/Keap1 signaling mechanism. Among these, 12 Generally Recognized As Safe (GRAS) certified nutraceuticals, sulforaphane is the most extensively studied compound in modulating Keap1-Nrf signaling. Even though there is much evidence at preclinical levels, further high-quality research is still required to validate the potential role of these nutraceuticals in Keap1-Nrf2 modulation.

Automated summary

Keap1-Nrf2 is a crucial signaling cascade for promoting or preventing carcinogenesis. Nutraceuticals, as dietary agents with health benefits, show great potential as chemoprevention agents for cancer. This review systematically analyzes the role of 12 different nutraceuticals in modulating the Nrf2/Keap1 signaling mechanism. Although there is considerable preclinical evidence, further high-quality research is needed to validate the potential role of these nutraceuticals in Keap1-Nrf2 modulation.