☆ 4.7 Article

Necroptosis inhibits autophagy by regulating the formation of RIP3/p62/Keap1 complex in shikonin-induced ROS dependent cell death of human bladder cancer

PHYTOMEDICINE (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Oncology

Genetic and epigenetic regulation of the NRF2-KEAP1 pathway in human lung cancer

Nuria Camina et al.

Summary: The activation of the NRF2 transcription factor plays a crucial role in detoxifying electrophilic carcinogens and preventing cancer, yet can also potentially exacerbate carcinogenesis in certain contexts. Understanding the activation of the NRF2-KEAP1 signaling pathway, its epigenetic regulation, and its role in oncogenesis is essential for elucidating the mechanisms of cancer development.

BRITISH JOURNAL OF CANCER (2022)

添加到收藏夹

Article Oncology

Cancer statistics, 2022

Rebecca L. Siegel et al.

Summary: Each year, the American Cancer Society compiles data on cancer occurrence and outcomes in the United States. The latest data shows that breast and prostate cancer progress has stagnated, while lung cancer has shown improvements in survival rates. Lung cancer incidence for advanced disease has declined while localized-stage rates have increased, resulting in higher survival rates. Mortality patterns align with incidence trends, with lung cancer deaths declining rapidly, breast cancer deaths slowing, and prostate cancer deaths stabilizing.

CA-A CANCER JOURNAL FOR CLINICIANS (2022)

添加到收藏夹

Article Plant Sciences

Uvangoletin, extracted from Sarcandra glabra, exerts anticancer activity by inducing autophagy and apoptosis and inhibiting invasion and migration on hepatocellular carcinoma cells

Junyi Shen et al.

Summary: Uvangoletin can induce apoptotic and autophagic cell death, inhibit cell proliferation and metastasis on HepG2 cells through Akt/mTOR, MAPK, and TGF beta/Smad2 signal pathways.

PHYTOMEDICINE (2022)

添加到收藏夹

Review Plant Sciences

Shikonin, a naphthalene ingredient: Therapeutic actions, pharmacokinetics, toxicology, clinical trials and pharmaceutical researches

Qiang Sun et al.

Summary: Shikonin, a major phytochemical component of Lithospermum erythrorhizon, shows promising therapeutic effects on various diseases by regulating multiple signaling pathways. However, its pharmacokinetics reveal low oral bioavailability and potential toxicological effects, such as nephrotoxicity and skin allergies. Clinical trials validating its pharmacodynamics and pharmacokinetics are limited, with potential for pharmaceutical innovation to develop shikonin-based drugs for clinical use.

PHYTOMEDICINE (2022)

添加到收藏夹

Article Cell Biology

CAMK2/CaMKII activates MLKL in short-term starvation to facilitate autophagic flux

Qionghui Zhan et al.

Summary: MLKL plays a key role in cell death and endosomal trafficking, with CAMK2-mediated phosphorylation promoting autophagy during short-term starvation. This pathway protects cells from starvation-induced death and is independent of RIPK3, suggesting new roles for the pseudokinase in cell survival and metabolism.

AUTOPHAGY (2022)

添加到收藏夹

Article Chemistry, Medicinal

Recent advances of antitumor shikonin/alkannin derivatives: A comprehensive overview focusing on structural classification, synthetic approaches, and mechanisms of action

Mehdi Valipour

Summary: This review provides comprehensive data by reviewing studies conducted over the last two decades on the structural classification, synthesis methods, and diversity of the anti-tumor mechanism of action of shikonin derivatives.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

添加到收藏夹

Review Chemistry, Medicinal

Incomplete autophagy: Trouble is a friend

Qiang Zhang et al.

Summary: Incomplete autophagy plays a crucial role in disrupting cellular homeostasis and promoting cell death. It is closely relevant to the pathogenesis and progression of various human diseases, and also linked to the pharmacologic and toxicologic effects of several compounds.

MEDICINAL RESEARCH REVIEWS (2022)

添加到收藏夹

Article Cell Biology

Mosaic composition of RIP1-RIP3 signalling hub and its role in regulating cell death

Xin Chen et al.

Summary: Researchers used super-resolution microscopy to study the nanoscale structure of cellular necrosomes and discovered rod-shaped mosaic structures formed by RIP1 and RIP3 oligomers. They also revealed the roles and regulatory mechanisms of RIP1 and RIP3 in cell death.

NATURE CELL BIOLOGY (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Suppression of JNK/ERK dependent autophagy enhances Jaspine B derivative-induced gastric cancer cell death via attenuation of p62/Keap1/Nrf2 pathways

Feng Xu et al.

Summary: C-2, a derivative of Jaspine B, has been found to exhibit anti-gastric cancer activity by inducing autophagy through the activation of the JNK/ERK pathway. The activation of this pathway leads to the disruption of Beclin-1/Bcl-xL or Beclin-1/Bcl-2 complexes, resulting in autophagy and up-regulation of p62. Furthermore, the release of Nrf2 from the p62/Keap1 complex enhances cell survival. However, JNK/ERK-dependent autophagy antagonizes the growth-inhibiting effect of C-2 on gastric cancer cells through the p62/Keap1/Nrf2 pathway.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

TRIM22 inhibits osteosarcoma progression through destabilizing NRF2 and thus activation of ROS/AMPK/mTOR/autophagy signaling

Wei Liu et al.

Summary: TRIM22 inhibits the progression of osteosarcoma by promoting proteasomal degradation of NRF2 and activating ROS/AMPK/mTOR/autophagy signaling. Therefore, targeting TRIM22/NRF2 could be a potential therapeutic strategy for treating osteosarcoma.

REDOX BIOLOGY (2022)

添加到收藏夹

Letter Biochemistry & Molecular Biology

Acetylshikonin inhibits inflammatory responses and Papain-like protease activity in murine model of COVID-19

Ning Lu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy

Weitong Gao et al.

Summary: Immunotherapy has made significant breakthroughs in cancer treatment, but the poor response of some tumors limits its application. Inducing non-apoptotic regulated cell death (RCD) may convert these unresponsive tumors into those that respond to immunotherapy. Autophagy, ferroptosis, pyroptosis, and necroptosis have been found to have both inhibitory and synergistic effects on antitumor immune responses, suggesting that targeted therapies against these processes combined with immunotherapy may be effective even in resistant tumors.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

添加到收藏夹

Review Oncology

Necroptosis and tumor progression

Jiong Yan et al.

Summary: Necroptosis, a form of programmed necrotic cell death, plays a crucial role in host defense and inflammatory diseases, and has emerged as an important factor in tumorigenesis and metastasis, suggesting its potential as a novel cancer therapy target.

TRENDS IN CANCER (2022)

添加到收藏夹

Review Oncology

Autophagy as a therapeutic target in pancreatic cancer

Max Piffoux et al.

Summary: PDAC is characterized by early metastasis and resistance to therapy, with mutations in KRAS and TP53 showing little clinical efficacy. Autophagy, upregulated in PDAC, plays a role in resistance to treatments, making it a potential therapeutic target. Combining inhibitors of the ERK/MAPK pathway with autophagy inhibitors has shown interesting results in PDAC models and other KRAS-driven cancers.

BRITISH JOURNAL OF CANCER (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein

Shijie Fan et al.

Summary: The autophagic protein LC3 interacts with other autophagy proteins through LC3-interaction regions, offering a promising target for intervention. A small molecule modulator, DC-LC3in-D5, has been discovered to covalently modify LC3A/B protein, compromising autophagic structures and substrate degradation in cells. This finding could serve as a powerful tool for autophagy research and therapeutic interventions.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

添加到收藏夹

Review Cell Biology

Novel target for treating Alzheimer's Diseases: Crosstalk between the Nrf2 pathway and autophagy

Weiwei Zhang et al.

Summary: The Nrf2 pathway and autophagy are important intracellular defense systems in mammals, with p62 acting as a connector between the two through a positive feedback loop to enhance cellular protection. Studies have shown that the p62-activated noncanonical Nrf2 pathway is a significant marker of neurodegenerative diseases.

AGEING RESEARCH REVIEWS (2021)

添加到收藏夹

Article Immunology

Mitophagy-mediated adipose inflammation contributes to type 2 diabetes with hepatic insulin resistance

Feng He et al.

Summary: By analyzing the transcriptome landscape in human adipocytes, this study revealed elevated mitochondrial ROS pathway and NF-KB signaling, as well as altered fatty acid metabolism in T2DM adipocytes. Mouse experiments showed that adipose-specific deletion of mitochondrial Trx2 led to excessive mitophagy, increased inflammation, and lipolysis in white adipose tissues. Treatment with ROS scavenger or NF-KB inhibitor improved metabolic disorders and T2DM progression in mice.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Necrostatin-1 and necroptosis inhibition: Pathophysiology and therapeutic implications

Liyuan Cao et al.

Summary: Necrostatin-1 (Nec-1) is an inhibitor of necroptosis that has been shown to play an important role in various diseases and has the potential to provide protection in diseases such as COVID-19. Research findings indicate that Nec-1 can ameliorate disease development by inhibiting the necroptosis signaling pathway.

PHARMACOLOGICAL RESEARCH (2021)

添加到收藏夹

Article Oncology

Shikonin Reduces Growth of Docetaxel-Resistant Prostate Cancer Cells Mainly through Necroptosis

Sascha D. Markowitsch et al.

Summary: Therapy resistance in advanced prostate carcinoma (PCa) leads to poor prognosis, necessitating new treatment options. Shikonin (SHI) has shown promising growth inhibition effects on both therapy-sensitive and DX-resistant PCa cell lines, primarily through induction of necroptosis.

CANCERS (2021)

添加到收藏夹

Article Cell Biology

TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy

Wenxian Wu et al.

Summary: This study identified RIPK3 as an AMPK-activating kinase, establishing a direct link between the kinases regulating autophagy and necroptosis.Activation of AMPK by RIPK3 leads to phosphorylation of autophagy-regulating proteins ULK1 and BECN1, while TNF-induced necroptosis blocks lysosomal degradation of autophagosomes. Dysregulation of SNARE complexes, including reduced levels of full-length STX17, was observed upon TNF treatment.

AUTOPHAGY (2021)

添加到收藏夹

Article Oncology

p62 functions as a signal hub in metal carcinogenesis

Zhuo Zhang et al.

Summary: Metals can be toxic and carcinogenic to humans, with ROS playing a key role in metal carcinogenesis. Autophagy is crucial for maintaining cellular homeostasis, with p62 serving as a pivotal molecule in various cellular functions related to cancer growth.

SEMINARS IN CANCER BIOLOGY (2021)

添加到收藏夹

Editorial Material Multidisciplinary Sciences

Crystal structure of SARS-CoV-2 main protease in complex with the natural product inhibitor shikonin illuminates a unique binding mode

Jian Li et al.

SCIENCE BULLETIN (2021)

添加到收藏夹

Article Cell Biology

RIP3 impedes transcription factor EB to suppress autophagic degradation in septic acute kidney injury

Ruizhao Li et al.

Summary: RIP3 plays a crucial role in suppressing autophagic degradation by obstructing the TFEB-lysosome pathway in septic AKI, suggesting potential therapeutic targets for the prevention and treatment of the condition.

CELL DEATH & DISEASE (2021)

添加到收藏夹

Article Oncology

Cancer incidence, mortality, and burden in China: a time-trend analysis and comparison with the United States and United Kingdom based on the global epidemiological data released in 2020

Haibo Qiu et al.

Summary: Cancer is a major cause of death and economic burden in China, with lower incidence but higher mortality and DALY rates compared to the US and UK. The cancer spectrum in China is changing, with increasing burden of certain cancers and a shift towards patterns seen in developed countries.

CANCER COMMUNICATIONS (2021)

添加到收藏夹

Article Medicine, Research & Experimental

TNF-α-dependent neuronal necroptosis regulated in Alzheimer's disease by coordination of RIPK1-p62 complex with autophagic UVRAG

Chong Xu et al.

Summary: Activated neuronal necroptosis in Alzheimer's disease depends on upstream TNF-alpha/TNFR1 signaling, with p62 recruiting RIPK1 upon TNF-alpha stimulation to induce downstream RIPK1/RIPK3/MLKL cascade leading to cell death. The ectopic accumulation of p62 is caused by impaired autophagy flux mediated by UVRAG downregulation during TNF-alpha-promoted necroptosis. Overexpression of UVRAG inhibits neuronal necroptosis in both cell and mouse models of Alzheimer's disease, highlighting a potential therapeutic target.

THERANOSTICS (2021)

添加到收藏夹

Article Cell Biology

Metformin mediates cardioprotection against aging-induced ischemic necroptosis

Chen Li et al.

AGING CELL (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Autophagy and autophagy-related proteins in cancer

Xiaohua Li et al.

MOLECULAR CANCER (2020)

添加到收藏夹

Review Pharmacology & Pharmacy

Targeting necroptosis in anticancer therapy: mechanisms and modulators

Ying Wu et al.

ACTA PHARMACEUTICA SINICA B (2020)

添加到收藏夹

Review Cell Biology

Mechanisms governing autophagosome biogenesis

Hitoshi Nakatogawa

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

添加到收藏夹

Review Medicine, General & Internal

Bladder Cancer: A Review

Andrew T. Lenis et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Shikonin induces colorectal carcinoma cells apoptosis and autophagy by targeting galectin-1/JNK signaling axis

Nan Zhang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2020)

添加到收藏夹

Review Plant Sciences

Linking Autophagy to Abiotic and Biotic Stress Responses

Santiago Signorelli et al.

TRENDS IN PLANT SCIENCE (2019)

添加到收藏夹

Editorial Material Cell Biology

Autophagy in disease: hunger for translation

Francesca Pentimalli

CELL DEATH & DISEASE (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

The role of necroptosis in cancer biology and therapy

Yitao Gong et al.

MOLECULAR CANCER (2019)

添加到收藏夹

Article Oncology

MLKL contributes to shikonin-induced glioma cell necroptosis via promotion of chromatinolysis

Ye Ding et al.

CANCER LETTERS (2019)

添加到收藏夹

Review Pharmacology & Pharmacy

Pharmacological properties and derivatives of shikonin-A review in recent years

Chuanjie Guo et al.

PHARMACOLOGICAL RESEARCH (2019)

添加到收藏夹

Article Oncology

SP600125 enhances C-2-induced cell death by the switch from autophagy to apoptosis in bladder cancer cells

Haiyang Yu et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Nestin regulates cellular redox homeostasis in lung cancer through the Keap1-Nrf2 feedback loop

Jiancheng Wang et al.

NATURE COMMUNICATIONS (2019)

添加到收藏夹

Letter Cell Biology

Induction of autophagy by depolarization of mitochondria

Konstantin G. Lyamzaev et al.

AUTOPHAGY (2018)

添加到收藏夹

Article Cell Biology

A brief history of autophagy from cell biology to physiology and disease

Noboru Mizushima

NATURE CELL BIOLOGY (2018)

添加到收藏夹

Review Physiology

THE KEAP1-NRF2 SYSTEM: A THIOL-BASED SENSOR-EFFECTOR APPARATUS FOR MAINTAINING REDOX HOMEOSTASIS

Masayuki Yamamoto et al.

PHYSIOLOGICAL REVIEWS (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Death receptor 3 mediates necroptotic cell death

Sebastian Bittner et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2017)

添加到收藏夹

Article Immunology

Regression of apoptosis-resistant colorectal tumors by induction of necroptosis in mice

Gui-Wei He et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

添加到收藏夹

Article Multidisciplinary Sciences

RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome

Yingying Zhang et al.

NATURE COMMUNICATIONS (2017)

添加到收藏夹

Article Oncology

Camptothecin suppresses NRF2-ARE activity and sensitises hepatocellular carcinoma cells to anticancer drugs

Feng Chen et al.

BRITISH JOURNAL OF CANCER (2017)

添加到收藏夹

Article Engineering, Biomedical

Killing colon cancer cells through PCD pathways by a novel hyaluronic acid-modified shell-core nanoparticle loaded with RIP3 in combination with chloroquine

Xueyan Hou et al.

BIOMATERIALS (2017)

添加到收藏夹

Article Cell Biology

The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis

Megan L. Goodall et al.

DEVELOPMENTAL CELL (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

RIPK3 regulates p62-LC3 complex formation via the caspase-8-dependent cleavage of p62

Yu Matsuzawa et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

添加到收藏夹

Article Microbiology

RIP3 Regulates Autophagy and Promotes Coxsackievirus B3 Infection of Intestinal Epithelial Cells

Katharine G. Harris et al.

CELL HOST & MICROBE (2015)

添加到收藏夹

Article Cell Biology

Ppm1b negatively regulates necroptosis through dephosphorylating Rip3

Wanze Chen et al.

NATURE CELL BIOLOGY (2015)

添加到收藏夹

Review Immunology

Regulation of tumour necrosis factor signalling: live or let die

Dirk Brenner et al.

NATURE REVIEWS IMMUNOLOGY (2015)

添加到收藏夹

Review Oncology

Indoleamine 2,3-dioxygenase pathways of pathogenic inflammation and immune escape in cancer

George C. Prendergast et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy

AJ Muller et al.

NATURE MEDICINE (2005)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.