Ent- kaurane diterpenoids from Isodon japonica var. glaucocalyx with PCSK9 inhibitory activities

Article Chemistry, Multidisciplinary

Determination of the Anti-Oxidative Stress Mechanism of Isodon suzhouensis Leaves by Employing Bioinformatic and Novel Research Technology

Wei Wang et al.

Summary: The present study aimed to explore the active components in Isodon suzhouensis leaf extracts responsible for antioxidant effects against oxidative stress and the potential mechanism of this activity. It was found that Isodon suzhouensis leaf extracts contain rutin, isoquercetin, glaucocalyxin A, glaucocalyxin B, and other compounds with antioxidant activity. Further network pharmacological analyses and in vitro experimentation showed that Isodon suzhouensis leaf extracts interfere with TNF and the p38 MAPK signaling pathway for antioxidant effects against oxidative stress.

ACS OMEGA (2023)

添加到收藏夹

Article Plant Sciences

Novel triterpenoids from Alisma plantago-aquatica with influence on LDL uptake in HepG2 cells by inhibiting PCSK9

Jianqing Zhang et al.

Summary: This study explored natural small molecules with anti-hyperlipidemia activity through PCSK9 from Alisma plantago-aquatica. It discovered six novel triterpenoids, including three unusual nor-triterpenoids and three protostane-type triterpenoids, along with thirty-four known ones. The results indicate that protostane triterpenoids may serve as a new source for PCSK9 inhibitors, with potential anti-hyperlipidemia effects.

PHYTOMEDICINE (2022)

添加到收藏夹

Article Food Science & Technology

Identification and characterization of potential antioxidant components in Isodon amethystoides (Benth.) Hara tea leaves by UPLC-LTQ-Orbitrap-MS

Hong Duan et al.

Summary: A total of 17 compounds were identified in Isodon amethystoides (Benth.) Hara (IA) leaves extract, with 14 of them being novel findings. Flavonoid components exhibited better free radical scavenging ability, and a significant correlation was observed between diterpenoid compounds content and flavonoids activity. These results provide an experimental basis for the extraction and separation of antioxidant chemical constituents of IA.

FOOD AND CHEMICAL TOXICOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

A pair of threonines mark ent-kaurene synthases for phytohormone biosynthesis

Reid Brown et al.

Summary: Despite not being essential for the efficient production of ent-kaurene from ent-CPP, a pair of conserved threonines in all land plant KS involved in phytohormone biosynthesis play a role in distinguishing these critical enzymes, even though they do not seem to have a specific function in enzyme function, protein structure, stability, or transcription/translation.

PHYTOCHEMISTRY (2021)

添加到收藏夹

Review Geriatrics & Gerontology

Targeting NLRP3 Inflammasome in the Treatment Of Diabetes and Diabetic Complications: Role of Natural Compounds from Herbal Medicine

Ying Bai et al.

Summary: The NLRP3 inflammasome plays a vital role in the progression of diabetes and its complications, while natural herbal medicine can ameliorate symptoms and delay progression due to its anti-inflammatory and anti-oxidative properties. Understanding the relationship between inflammation and metabolic disorders through natural compounds targeting NLRP3 inflammasome sheds light on potential therapies for treating diabetes and its complications.

AGING AND DISEASE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology