期刊
PHYTOCHEMISTRY
卷 211, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2023.113701
关键词
Garcinia schomburgkiana; Clusiaceae; Benzophenone; Schomburginone; Cytotoxic; Anti-inflammatory
Ten undescribed benzophenones, schomburginones A-J, were isolated from Garcinia schomburgkiana leaves. Their structures were determined using spectroscopic techniques, and their cytotoxic and anti-inflammatory activities were evaluated. These compounds showed promising cytotoxicity against HeLa cells and significant NO inhibitory activity in RAW 264.7 macrophage cells, making them potential candidates for anticancer drug development.
Ten undescribed benzophenones, schomburginones A-J, together with 14 known analogs were isolated from the leaves of Garcinia schomburgkiana, an edible plant native to the Indochina region. The structures of the unde-scribed compounds were elucidated by NMR combined with HRMS spectroscopy, while their absolute config-urations were determined using ECD and single-crystal X-ray diffraction analysis. The isolated metabolites represent benzophenone derivatives containing a modified monoterpene unit, including tri-and tetracyclic skeletons, which are rarely found in genus Garcinia. The cytotoxic evaluation on three cancerous cell lines demonstrated that schomburginone G, schomburginone H, and 3-geranyl-2,4,6-trihydroxybenzophenone were active against HeLa cells with IC50 values in the range of 12.2-15.7 mu M, respectively, and selective compared to the non-cancerous L929 cells (SI > 3.5). In addition, the three cytotoxic compounds together with clusiacyclol A showed significant NO inhibitory activity in RAW 264.7 macrophage cells over 85% inhibition without obvious cytotoxicity at a final concentration of 100 mu M. The promising activities of these compounds in cytotoxic and anti-inflammatory assays make them attractive for further study in the development of anticancer drugs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据