Cembrane diterpenoids: Chemistry and pharmacological activities

Cembrane diterpenoids (cembranoids), characterized by a 14-membered carbon ring and wide variety of functional groups, found in marine and terrestrial organisms. Many studies have shown that cembrane diterpenoids have cytotoxic and anti-inflammatory activities and are widely used in the development of new drugs. This review covered publications from 2011 to 2022 and classified the cembrane-type diterpenoids into isopropyl (ene) type, gamma-lactone or unsaturated five-membered ring, delta-lactone or unsaturated six-membered ring, epsilon-lactone or unsaturated seven-membered ring, and other cembrane diterpenes. In addition, the biological activity and structure-activity relationship were summarized. This will provide guidance for new cembrane-type diterpenes as lead compounds to explore their potential application for treating cancer and inflammatory diseases.

Automated summary

This review summarizes the research on cembrane diterpenoids from 2011 to 2022, classifying them into different types and summarizing their biological activity and structure-activity relationship. It provides guidance for the development of new cembrane-type diterpenes as potential drugs for cancer and inflammatory diseases.