4.5 Article

Urocanic acid facilitates acquisition of object recognition memory in mice

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PHYSIOLOGY & BEHAVIOR
卷 266, 期 -, 页码 -

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PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.physbeh.2023.114201

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Urocanic acid; Memory acquisition; Long-term memory; Short-term memory; Location recognition; Object recognition

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Trans-urocanic acid (UCA) has been found to play a role in short-term and long-term memory. In this study, the effect of UCA on memory acquisition in mice was investigated using novel object recognition (NOR) and object location recognition (OLR) tasks. The results showed that UCA facilitated both short-term and long-term memory acquisition, with a higher dose facilitating long-term memory acquisition in both tasks. The enhancing effect of UCA on memory acquisition was not dependent on nonspecific responses.
Trans-urocanic acid (UCA), an isomer of cis-UCA that is mainly located in the skin, has recently been reported to have a role in short-term working memory and in the consolidation, reconsolidation and retrieval of long-term memory. However, its effect on memory acquisition remains unclear. In the present study, the effect of UCA on short-term and long-term memory acquisition in mice was investigated using novel object recognition (NOR) and object location recognition (OLR) protocols that each involved three stages: habituation, sampling and testing. UCA was intraperitoneally injected 0.5 h pre-sampling, and the discrimination index during subsequent testing was determined in NOR and OLR tasks. The results showed that 10 mg/kg UCA significantly facilitated shortterm and long-term memory acquisition in both types of tasks. Furthermore, 30 mg/kg UCA significantly facilitated long-term memory acquisition in the NOR task and tended to facilitate long-term memory acquisition in the OLR tasks but did not facilitate short-term memory acquisition in either task. Additionally, the enhancing role of UCA on memory acquisition was not dependent on changes of nonspecific responses, e.g. exploratory behavior and locomotor activity. The current study suggests that UCA facilitates short-term and long-term recognition memory acquisition, which further extends the functional role of UCA in the brain function.

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