期刊
PHYSIOLOGY & BEHAVIOR
卷 268, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.physbeh.2023.114233
关键词
Sign -tracking; Addiction; Serotonin; Fluoxetine; Escitalopram; Citalopram
This study examined the effectiveness of serotonergic anti-depressants in reducing sign-tracking behavior and preventing cue-triggered relapse. The results showed that these drugs were able to reduce sign-tracking behavior, although their effects on goal-tracking varied.
Sign-tracking is a behavior with relevance to cue-triggered relapse addiction, a Pavlovian conditioned approach behavior directed at the conditioned stimulus. The study examined one strategy for reducing the magnetic pull of drug-associated conditioned stimuli, using selective serotonin reuptake inhibitors (SSRIs) citalopram (0, 10, and 20 mg/kg), escitalopram (0, 10, and 20 mg/kg) and fluoxetine (0, 5, and 10 mg/kg). Male Sprague-Dawley rats were first trained in a standard sign-tracking task and then acutely administered these drugs in a series of three experiments. In each study, it was found that measures of sign-tracking were reduced, although effects on goal -tracking were different between drugs. This study provides evidence that administration of serotonergic anti-depressants is effective in reducing sign-tracking and may have some efficacy in preventing cue-triggered relapse.
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