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Mosaic Loss of Y Chromosome in White Blood Cells: Its Impact on Men's Health

期刊

PHYSIOLOGY
卷 38, 期 4, 页码 161-166

出版社

AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00008.2023

关键词

aneuploidy; clonal hematopoiesis; fibrosis; inflammation

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This article provides a brief overview of loss of Y chromosome (LOY) in blood and discusses the known risk factors for this condition. It then explores the associations between LOY and age-related disease traits. Finally, it delves into murine models and the potential mechanisms by which LOY contributes to disease.
We present a brief introduction of loss of Y chromosome (LOY) in blood and describe the known risk factors for this condition. We then overview the associations between LOY and age-related disease traits. Finally, we discuss murine models and the potential mechanisms by which LOY contributes to disease.

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