4.1 Article

Technological Modalities in the Assessment and Treatment of Disorders of Consciousness

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Neurosciences

Beyond alpha power: EEG spatial and spectral gradients robustly stratify disorders of consciousness

Michele Angelo Colombo et al.

Summary: Neurophysiological markers, such as EEG alpha power and spatio-spectral gradients, can be used to assess Disorders of Consciousness (DoC). Alpha power alone is not a reliable marker of consciousness and is suppressed in severe postanoxia cases. EEG spatio-spectral gradients, on the other hand, are a robust and generalizable marker that accurately stratify patients' consciousness, even in unresponsive cases. The clinical application of these markers can guide rehabilitation efforts.

CEREBRAL CORTEX (2023)

Article Rehabilitation

Repetitive transcranial magnetic stimulation improves consciousness in some patients with disorders of consciousness

Jianzhong Fan et al.

Summary: The study aimed to investigate the therapeutic efficacy of repetitive transcranial magnetic stimulation (rTMS) in patients with disorders of consciousness. A randomized, double-blinded, sham-controlled trial was conducted with 40 participants. The results showed that active rTMS treatment significantly improved consciousness in some patients, but not all.

CLINICAL REHABILITATION (2022)

Article Neurosciences

Long-term functional prognosis and related factors of spinal cord stimulation in patients with disorders of consciousness

Yi Yang et al.

Summary: This study explores the efficiency of spinal cord stimulation (SCS) in treating patients with disorders of consciousness (DoC) at different consciousness levels. The results showed that SCS has a positive outcome in a significant percentage of patients, with better outcomes found in younger patients and those with a minimally conscious state (MCS). However, more evidence-based randomized controlled trials are needed to confirm the efficacy of SCS as a treatment for DoC.

CNS NEUROSCIENCE & THERAPEUTICS (2022)

Review Clinical Neurology

Evoked and Event-Related Potentials as Biomarkers of Consciousness State and Recovery

Estelle Pruvost-Robieux et al.

Summary: The definition of consciousness has been a subject of interest for many scientists and philosophers. This study reviews different theoretical models supporting neural correlates of consciousness to better understand how evoked potentials can be identified as biomarkers of consciousness and recovery. A multimodal approach is suggested to improve the prediction of clinical outcomes in patients with consciousness disorders. Evoked potentials are found to be a cost-effective and easy-to-implement bedside examination technique with an important role in prognostic evaluation.

JOURNAL OF CLINICAL NEUROPHYSIOLOGY (2022)

Review Clinical Neurology

Transcranial Magnetic Stimulation in the Treatment of Neurological Diseases

Fahad A. Somaa et al.

Summary: TMS is widely used in psychiatric applications, but not yet common in treating neurological diseases. However, recent clinical studies have shown potential for TMS in various other neurological conditions, opening new doors for its application in neurology.

FRONTIERS IN NEUROLOGY (2022)

Article Neurosciences

Transcranial Pulsed-Current Stimulation versus Transcranial Direct Current Stimulation in Patients with Disorders of Consciousness: A Pilot, Sham-Controlled Cross-Over Double-Blind Study

Alice Barra et al.

Summary: This study investigated the feasibility and effectiveness of tPCS as a therapeutic tool in patients with disorders of consciousness (DoC) and compared it with prefrontal tDCS. The results showed that tPCS did not have a significant effect on EEG or behavioral outcomes, while tDCS improved behavior and increased frontal functional connectivity.

BRAIN SCIENCES (2022)

Article Neurosciences

EEG-based Brain-Computer Interfaces for people with Disorders of Consciousness: Features and applications. A systematic review

Valentina Galiotta et al.

Summary: This study aims to describe the characteristics of BCI systems based on EEG performed on DoC patients, including the control signals used, paradigm characteristics, classification algorithms, and applications. The study found that although BCI is a promising tool in the management, diagnosis, and prognosis evaluation of DoC patients, the results are still preliminary, and no definitive conclusions can be drawn.

FRONTIERS IN HUMAN NEUROSCIENCE (2022)

Article Neurosciences

Influence of High-Frequency Repetitive Transcranial Magnetic Stimulation on Neurobehavioral and Electrophysiology in Patients with Disorders of Consciousness

Jian-Min Chen et al.

Summary: This study investigated the effects of HF-rTMS on neural connectivity and neurobehavioral reactivity in patients with disorders of consciousness. The results showed that HF-rTMS can increase neural connectivity levels and is significantly related to clinical responses.

NEURAL PLASTICITY (2022)

Article Clinical Neurology

Short-term spinal cord stimulation in treating disorders of consciousness monitored by resting-state fMRI and qEEG: The first case report

Yi Yang et al.

Summary: This case report discusses the use of short-term SCS treatment in a patient with DOC, showing improvement monitored by rs-fMRI and qEEG. The results suggest that st-SCS may be effective in treating certain patients with DOC, reducing suffering and financial burden.

FRONTIERS IN NEUROLOGY (2022)

Article Clinical Neurology

Effects of short-term spinal cord stimulation on patients with prolonged disorder of consciousness: A pilot study

Yutong Zhuang et al.

Summary: This study evaluates the safety and efficacy of short-term spinal cord stimulation (st-SCS) for patients with prolonged disorder of consciousness (pDOC), and reveals the modulation characteristics of different frequencies of SCS. The results show that st-SCS is safe and effective in improving patients' level of consciousness, with a significant effect on patients with minimally conscious state minus (MCS-) type.

FRONTIERS IN NEUROLOGY (2022)

Article Neurosciences

Functional Connectivity Increases in Response to High-Definition Transcranial Direct Current Stimulation in Patients with Chronic Disorder of Consciousness

Jinying Han et al.

Summary: By conducting HD-tDCS sessions on patients with disorders of consciousness, this study found that increased functional connectivity in specific brain regions may be associated with improved consciousness, and may serve as a predictor for better long-term outcomes.

BRAIN SCIENCES (2022)

Article Clinical Neurology

Preliminary Study of Vagus Nerve Magnetic Modulation in Patients with Prolonged Disorders of Consciousness

Lingling Wang et al.

Summary: The study demonstrated the potential of VNMM treatment in improving pDOC patients, as evidenced by significant improvements in CRS-R and GCS scores, as well as improvements in BAEP grades. The findings provide a basis for future Phase 2 or Phase 3 studies on the use of VNMM in patients with pDOC.

NEUROPSYCHIATRIC DISEASE AND TREATMENT (2022)

Article Engineering, Biomedical

Toward Assessment of Sound Localization in Disorders of Consciousness Using a Hybrid Audiovisual Brain-Computer Interface

Jun Xiao et al.

Summary: This study developed a novel audiovisual brain-computer interface (BCI) system to assess sound localization in patients with disorders of consciousness (DOC). By analyzing electroencephalography data in real time, the system can detect whether the patients are attending to a specific target button, indicating sound localization ability.

IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING (2022)

Review Clinical Neurology

Managing disorders of consciousness: the role of electroencephalography

Yang Bai et al.

Summary: The review presents the current landscape of using novel EEG measures for diagnosing, estimating prognosis and supporting medicolegal decisions in patients with disorders of consciousness, highlighting the challenges and potential applications of these techniques in clinical practice.

JOURNAL OF NEUROLOGY (2021)

Review Clinical Neurology

Recovery from disorders of consciousness: mechanisms, prognosis and emerging therapies

Brian L. Edlow et al.

Summary: Significant progress has been made in detecting and predicting recovery of consciousness in patients with disorders of consciousness caused by severe brain injuries over the past two decades. Advanced neuroimaging and electrophysiological techniques have provided new insights into the biological mechanisms of consciousness recovery. Detection of covert consciousness in up to 15-20% of patients has shown potential for predicting functional recovery at 1 year post injury.

NATURE REVIEWS NEUROLOGY (2021)

Review Neurosciences

The effectiveness of median nerve electrical stimulation in patients with disorders of consciousness: a systematic review

Daniel Feller et al.

Summary: Despite conducting a systematic review, the effectiveness of median nerve electrical stimulation on consciousness level remains inconclusive. Some studies suggest a potential benefit on the number of hospitalization days in the ICU, while others indicate a higher percentage of patients regaining consciousness in the experimental group six months post-event.

BRAIN INJURY (2021)

Article Computer Science, Artificial Intelligence

An EEG-Based Brain Computer Interface for Emotion Recognition and Its Application in Patients with Disorder of Consciousness

Haiyun Huang et al.

Summary: This study proposed an EEG-based BCI system for emotion recognition, demonstrating efficient emotion recognition and promising results in detecting emotional states of patients with disorders of consciousness.

IEEE TRANSACTIONS ON AFFECTIVE COMPUTING (2021)

Review Neurosciences

Targeting neural oscillations with transcranial alternating current stimulation

Justin Riddle et al.

Summary: Neural oscillations at the network level synchronize brain activity between regions and temporal scales. Transcranial alternating current stimulation (tACS) is a promising tool for investigating the causal role of neural oscillations in cognition, with vast parameter space and potential for precision intervention in psychiatric illnesses.

BRAIN RESEARCH (2021)

Review Behavioral Sciences

Vagus nerve stimulation in brain diseases: Therapeutic applications and biological mechanisms

Yue Wang et al.

Summary: With the development of medical technology, vagus nerve stimulation (VNS) has been approved by the FDA as an alternative treatment for refractory epilepsy, refractory depression, cluster headaches, and migraines. Although VNS has shown promising results for more brain diseases like Parkinson's disease, autistic spectrum disorder, and traumatic brain injury, the specific biological mechanisms underlying its beneficial effects remain incompletely understood.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2021)

Article Engineering, Biomedical

Altered inter-frequency dynamics of brain networks in disorder of consciousness

Lihui Cai et al.

JOURNAL OF NEURAL ENGINEERING (2020)

Review Clinical Neurology

Therapeutic interventions in patients with prolonged disorders of consciousness

Aurore Thibaut et al.

LANCET NEUROLOGY (2019)

Article Neuroimaging

Decreased integration of EEG source-space networks in disorders of consciousness

Jennifer Rizkallah et al.

NEUROIMAGE-CLINICAL (2019)

Article Neurosciences

COALIA: A Computational Model of Human EEG for Consciousness Research

Siouar Bensaid et al.

FRONTIERS IN SYSTEMS NEUROSCIENCE (2019)

Review Neurosciences

Transcranial direct current stimulation in disorders of consciousness: a review

Ye Zhang et al.

INTERNATIONAL JOURNAL OF NEUROSCIENCE (2018)

Article Neurosciences

Fronto-parietal coherence response to tDCS modulation in patients with disorders of consciousness

Yang Bai et al.

INTERNATIONAL JOURNAL OF NEUROSCIENCE (2018)

Article Clinical Neurology

Feasibility of an EEG-based brain-computer interface in the intensive care unit

Camille Chatelle et al.

CLINICAL NEUROPHYSIOLOGY (2018)

Article Engineering, Biomedical

Assessment of Visual Pursuit in Patients With Disorders of Consciousness Based on a Brain-Computer Interface

Jun Xiao et al.

IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING (2018)

Article Psychology, Biological

Basic discriminative and semantic processing in patients in the vegetative and minimally conscious state

Helena Erlbeck et al.

INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY (2017)

Article Multidisciplinary Sciences

Night and day variations of sleep in patients with disorders of consciousness

Malgorzata Wislowska et al.

SCIENTIFIC REPORTS (2017)

Article Clinical Neurology

Brain-heart interactions reveal consciousness in noncommunicating patients

Federico Raimondo et al.

ANNALS OF NEUROLOGY (2017)

Review Clinical Neurology

Deep brain stimulation for disorders of consciousness: Systematic review of cases and ethics

Jonathan Vanhoecke et al.

BRAIN STIMULATION (2017)

Letter Biochemistry & Molecular Biology

Restoring consciousness with vagus nerve stimulation

Martina Corazzol et al.

CURRENT BIOLOGY (2017)

Review Psychology, Experimental

Evoked and event-related potentials in disorders of consciousness: A quantitative review

Boris Kotchoubey

CONSCIOUSNESS AND COGNITION (2017)

Article Clinical Neurology

Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS)

Jean-Pascal Lefaucheur et al.

CLINICAL NEUROPHYSIOLOGY (2017)

Article Clinical Neurology

Somatosensory attention identifies both overt and covert awareness in disorders of consciousness

Raechelle M. Gibson et al.

ANNALS OF NEUROLOGY (2016)

Article Clinical Neurology

Stratification of unresponsive patients by an independently validated index of brain complexity

Silvia Casarotto et al.

ANNALS OF NEUROLOGY (2016)

Article Neurosciences

Do you see me? The role of visual fixation consciousness differential diagnosis

Antonino Naro et al.

BRAIN RESEARCH (2016)

Review Medicine, General & Internal

Vagus nerve stimulation in clinical practice

Adam D. Farmer et al.

BRITISH JOURNAL OF HOSPITAL MEDICINE (2016)

Article Clinical Neurology

Standard EEG in diagnostic process of prolonged disorders of consciousness

Anna Estraneo et al.

CLINICAL NEUROPHYSIOLOGY (2016)

Article Rehabilitation

Sensorimotor Modulation Assessment and Brain-Computer Interface Training in Disorders of Consciousness

Damien Coyle et al.

ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION (2015)

Article Cell Biology

Connecting the P300 to the diagnosis and prognosis of unconscious patients

Ran Li et al.

NEURAL REGENERATION RESEARCH (2015)

Article Behavioral Sciences

Probing ERP correlates of verbal semantic processing in patients with impaired consciousness

Benjamin Rohaut et al.

NEUROPSYCHOLOGIA (2015)

Article Engineering, Biomedical

Detecting awareness in patients with disorders of consciousness using a hybrid brain-computer interface

Jiahui Pan et al.

JOURNAL OF NEURAL ENGINEERING (2014)

Article Clinical Neurology

Visual processing during recovery from vegetative state to consciousness: Comparing behavioral indices to brain responses

V. J. M. Wijnen et al.

NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY (2014)

Article Engineering, Biomedical

Electroencephalographic profiles for differentiation of disorders of consciousness

Urszula Malinowska et al.

BIOMEDICAL ENGINEERING ONLINE (2013)

Article Clinical Neurology

Abnormal Corticospinal Excitability in Patients with Disorders of Consciousness

Natallia Lapitskaya et al.

BRAIN STIMULATION (2013)

Article Cell Biology

A Theoretically Based Index of Consciousness Independent of Sensory Processing and Behavior

Adenauer G. Casali et al.

SCIENCE TRANSLATIONAL MEDICINE (2013)

Article Clinical Neurology

Application of nonlinear dynamics analysis in assessing unconsciousness: A preliminary study

Dong-yu Wu et al.

CLINICAL NEUROPHYSIOLOGY (2011)

Article Clinical Neurology

Information Communication Networks in Severe Traumatic Brain Injury

Luca Pollonini et al.

BRAIN TOPOGRAPHY (2010)

Article Clinical Neurology

Event-related potentials (MMN and novelty P3) in permanent vegetative or minimally conscious states

Catherine Fischer et al.

CLINICAL NEUROPHYSIOLOGY (2010)

Article Multidisciplinary Sciences

Central thalamic contributions to arousal regulation and neurological disorders of consciousness

Nicholas D. Schiff

MOLECULAR AND BIOPHYSICAL MECHANISMS OF AROUSAL, ALERTNESS, AND ATTENTION (2008)

Article Clinical Neurology

Voluntary brain processing in disorders of consciousness

C. Schnakers et al.

NEUROLOGY (2008)

Article Neurosciences

Mismatch negativity to the patient's own name in chronic disorders of consciousness

Pengmin Qin et al.

NEUROSCIENCE LETTERS (2008)

Article Neurosciences

Sleep cycle in patients in a state of permanent unconsciousness

M Isono et al.

BRAIN INJURY (2002)