☆ 4.7 Review

Integrins in cancer: Emerging mechanisms and therapeutic opportunities

PHARMACOLOGY & THERAPEUTICS (2023)

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Article Oncology

Oxidative stress-induced FAK activation contributes to uterine serous carcinoma aggressiveness

Isabel C. Lopez-Mejia et al.

Summary: Uterine serous carcinoma (USC) is a highly metastatic and fatal form of endometrial cancer (EC). This study identified focal adhesion kinase (FAK) as a highly activated tyrosine kinase in USC and showed that targeting FAK can inhibit cell growth and reduce migration in USC cell lines. The study also revealed that oxidative stress is increased in USC tumors compared to endometrioid endometrial carcinoma (EEC), and ROS-mediated FAK activation plays a role in cell migration and poor prognosis in USC.

MOLECULAR ONCOLOGY (2023)

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Article Oncology

Alliance A071401: Phase II Trial of Focal Adhesion Kinase Inhibition in Meningiomas With Somatic NF2 Mutations

Priscilla K. Brastianos et al.

Summary: Patients with progressive or recurrent meningiomas have limited systemic therapy options. The FAK inhibitor, GSK2256098, was found to be well tolerated and showed improved progression-free survival at 6 months in patients with NF2-mutated meningiomas.

JOURNAL OF CLINICAL ONCOLOGY (2023)

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Review Oncology

Hallmarks of Cancer: New Dimensions

Douglas Hanahan

Summary: The concept of the hallmarks of cancer is a tool for simplifying the complexity of cancer phenotypes and genotypes into basic principles. This article proposes phenotypic plasticity and disrupted differentiation as distinct hallmark capabilities, and discusses nonmutational epigenetic reprogramming and polymorphic microbiomes as enabling characteristics. Additionally, the importance of senescent cells in the tumor microenvironment is highlighted. The integrative concept of the hallmarks of cancer helps in understanding the mechanisms of cancer development and applying that knowledge to cancer medicine.

CANCER DISCOVERY (2022)

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Article Oncology

Connexin 43 confers chemoresistance through activating PI3K

Kevin J. Pridham et al.

Summary: This study reveals that the protein connexin 43 (Cx43) is highly expressed in a subpopulation of glioblastoma and is associated with poor prognosis and chemoresistance. Targeting Cx43 can sensitize glioblastoma cells to chemotherapy by inactivating phosphatidylinositol-3 kinase (PI3K). Furthermore, combining Cx43 inhibition with PIK3CB/p110 beta-selective inhibitors can synergistically overcome chemoresistance in glioblastoma cells.

ONCOGENESIS (2022)

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Article Cell Biology

Deubiquitinating enzyme USP9X regulates metastasis and chemoresistance in triple-negative breast cancer by stabilizing Snail1

Tangming Guan et al.

Summary: This study reveals the important regulatory mechanism of breast cancer metastasis and chemoresistance, namely the USP9X-Snail1 axis, and provides a rationale for potential therapeutic interventions in the treatment of TNBC.

JOURNAL OF CELLULAR PHYSIOLOGY (2022)

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Article Oncology

Targeting TROY-mediated P85a/AKT/TBX3 signaling attenuates tumor stemness and elevates treatment response in hepatocellular carcinoma

Beilei Liu et al.

Summary: This study found that TROY is highly expressed in hepatocellular carcinoma (HCC) and is associated with poor prognosis and tumor metastasis. Functional studies showed that TROY promotes cancer stem cell-like properties in HCC cells and activates the PI3K/AKT/TBX3 signaling pathway to promote tumor growth and metastasis.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

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Review Biotechnology & Applied Microbiology

Emerging therapeutic opportunities for integrin inhibitors

R. J. Slack et al.

Summary: Integrins play crucial roles in cell adhesion and signaling, making them potential therapeutic targets. This review discusses the challenges and development of integrin inhibitors, particularly those targeting integrins with an alpha v-subunit. Opportunities exist for learning from previous trials and exploring new modalities in integrin drug design.

NATURE REVIEWS DRUG DISCOVERY (2022)

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Article Oncology

Targeting of the alphav beta3 integrin complex by CAR-T cells leads to rapid regression of diffuse intrinsic pontine glioma and glioblastoma

Dustin A. Cobb et al.

Summary: This study highlights the potential of alpha(v)beta(3) CAR-T cells for the immunotherapeutic treatment of aggressive brain tumors. These CAR-T cells efficiently killed tumor cells and demonstrated low expression in normal tissues, reducing the risk of off-target toxicity.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

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Review Biochemistry & Molecular Biology

Integrin Alpha v Beta 6 (αvβ6) and Its Implications in Cancer Treatment

Ewa Brzozowska et al.

Summary: Integrins are crucial for cell adhesion, migration, and positioning. Studies have shown that the expression levels of Integrin αVβ6 are closely related to malignant diseases and patient prognosis. It plays a significant role in cancer progression and the activation of transforming growth factor β(TGF-β). While essential for normal function in healthy individuals, it can also be a target for cancer treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Medicine, Research & Experimental

Blockade of integrin signaling reduces chemotherapy-induced premature senescence in collagen cultured bladder cancer cells

Linghui Deng et al.

Summary: Based on our findings, the integrin beta 1/AKT cascade primarily acted to induce premature senescence in bladder cancer cells cultured in collagen gel, attenuating chemotherapy-induced apoptosis. Targeting integrin beta 1 might be a feasible approach to eradicate bladder cancer.

PRECISION CLINICAL MEDICINE (2022)

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Article Oncology

Alpelisib Monotherapy for PI3K-Altered Pretreated Advanced Breast Cancer A Phase II Study

Peter Savas et al.

Summary: Alpelisib monotherapy demonstrated efficacy in heavily pretreated ER + breast cancer, and the dynamics of PIK3CA mutation and ESR1 mutation detected in plasma can serve as candidate biomarkers for predicting treatment response.

CANCER DISCOVERY (2022)

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Review Medicine, Research & Experimental

Integrin-mediated cancer progression as a specific target in clinical therapy

Jian-Rui Chen et al.

Summary: Integrins play crucial roles in cancer progression and can be used for cancer diagnosis and targeted therapy. Despite numerous integrin inhibitors being investigated in clinical trials, challenges exist in the research and development of integrin inhibitors, requiring better pharmacological effects and experimental models.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Oncology

3D matrix promotes cell dedifferentiation into colorectal cancer stem cells via integrin/cytoskeleton/glycolysis signaling

Tong Han et al.

Summary: This study provides evidence that colorectal cancer cells can dedifferentiate to cancer stem cells and regain stem-like properties when cultured in the presence of extracellular matrix reagents. The 3D extracellular matrix mediates cytoskeletal changes, which contribute to the release of a protein and the degradation of an enzyme, resulting in enhanced glycolysis and upregulation of a transcription factor, ultimately promoting tumor progression.

CANCER SCIENCE (2022)

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Article Biochemistry & Molecular Biology

Integrin regulation by tissue factor promotes cancer stemness and metastatic dissemination in breast cancer

Betul Unlu et al.

Summary: TF expression in breast cancer is associated with metastasis and cancer stemness, blockade of TF signaling can inhibit metastasis and reduce expression of pro-metastatic markers.

ONCOGENE (2022)

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Article Cell Biology

MicroRNA-485-5p targets keratin 17 to regulate oral cancer stemness and chemoresistance via the integrin/FAK/Src/ERK/beta-catenin pathway

Te-Hsuan Jang et al.

Summary: The study revealed the association between KRT17 and cancer stemness and chemoresistance, providing important evidence for the development of new therapeutic strategies for oral squamous cell carcinoma.

JOURNAL OF BIOMEDICAL SCIENCE (2022)

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Article Oncology

Integrin αvβ6-TGFβ-SOX4 Pathway Drives Immune Evasion in Triple-Negative Breast Cancer

Archis Bagati et al.

Summary: SOX4 transcription factor plays a key role in mediating resistance to T cell-mediated cytotoxicity in TNBC cells, and inhibiting it can increase the expression of genes in important immune pathways. The integrin αvβ6 receptor regulates the expression of SOX4, and targeting the integrin αvβ6-TGFβ-SOX4 pathway provides therapeutic opportunities for TNBC and other aggressive cancers of epithelial origin.

CANCER CELL (2021)

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Article Cell Biology

Integrin α2β1 inhibition attenuates prostate cancer cell proliferation by cell cycle arrest, promoting apoptosis and reducing epithelial-mesenchymal transition

Zahra Salemi et al.

Summary: The study explores the effects of selective inhibition of integrin alpha 2 beta 1 on prostate cancer cells, showing that suppression of integrin alpha 2 beta 1 can inhibit EMT, decrease cell migration capacity, reduce cell proliferation, induce G1 cell cycle arrest, and promote apoptosis. These findings suggest a critical role for integrin alpha 2 beta 1 in the proliferation of prostate cancer cells.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

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Article Oncology

Thrombospondin 4/integrin α2/HSF1 axis promotes proliferation and cancer stem-like traits of gallbladder cancer by enhancing reciprocal crosstalk between cancer-associated fibroblasts and tumor cells

Yu Shi et al.

Summary: Our study demonstrates that a complex TSP-4/integrin alpha 2/HSF1/TGF-beta cascade mediates the reciprocal interactions between GBC cells and CAFs, providing a potential therapeutic target for gallbladder cancer patients.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Oncology

Constitutive activation of integrin αvβ3 contributes to anoikis resistance of ovarian cancer cells

Romana Dolinschek et al.

Summary: The study investigated the mechanisms of survival in ascitic ovarian cancer cells and found that a specific variant of the αvß3 integrin can affect tumor cell resistance to anoikis and cisplatin. This variant promotes activation of survival signaling pathways, inhibiting apoptosis and impacting peritoneal metastasis.

MOLECULAR ONCOLOGY (2021)

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Review Oncology

Targeting cancer-promoting inflammation - have anti-inflammatory therapies come of age?

Jiajie Hou et al.

Summary: The immune system plays crucial roles in cancer development and treatment, with adaptive immunity capable of preventing or constraining cancer and innate immunity and inflammation often promoting tumorigenesis. While immunotherapies derived from preclinical studies have shown efficacy in treating cancer, treatments targeting cancer-associated inflammation still require successful implementation. Anti-inflammatory agents have the potential to delay cancer onset and enhance the efficacy of conventional and next-generation cancer therapies.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Article Biochemistry & Molecular Biology

Integrin alpha5 in human breast cancer is a mediator of bone metastasis and a therapeutic target for the treatment of osteolytic lesions

Francesco Pantano et al.

Summary: This study identified ITGA5 as a mediator of breast-to-bone metastasis, with high expression correlating with poor bone metastasis-free survival. Silencing ITGA5 impaired tumor cell functions and bone metastasis, while inhibition with M200 showed similar effects.

ONCOGENE (2021)

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Article Oncology

Milk fat globule EGF factor 8 restores mitochondrial function via integrin-medicated activation of the FAK-STAT3 signaling pathway in acute pancreatitis

Yifan Ren et al.

Summary: MFG-E8 acts as an endogenous protective mediator in the pathogenesis of acute pancreatitis, possibly by restoring mitochondrial function via activation of the integrin-FAK-STAT3 signaling pathway. Targeting the action of MFG-E8 may present a potential therapeutic option for AP.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

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Review Biochemistry & Molecular Biology

Integrin Regulation in Immunological and Cancerous Cells and Exosomes

Zay Yar Soe et al.

Summary: Integrins play a crucial role in cell adhesion, intercellular communication, and functions of tumor and immune cell exosomes, with potential implications in tumor microenvironment modulation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Oncology

Focal adhesion kinase inhibition synergizes with nab-paclitaxel to target pancreatic ductal adenocarcinoma

T. Y. S. Le Large et al.

Summary: In pancreatic ductal adenocarcinoma (PDAC), high activity of multiple receptor tyrosine kinases was observed, with the non-receptor kinase FAK identified as a potential target. Inhibition of FAK with defactinib reduced phosphorylation profiles, demonstrating anti-proliferative and anti-migratory effects. Combination therapy with (nab-)paclitaxel showed synergistic effects on cell proliferation and reduced tumor growth in PDAC.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Cell Biology

Src acts as the target of matrine to inhibit the proliferation of cancer cells by regulating phosphorylation signaling pathways

Xi Zhang et al.

Summary: Matrine targets Src, inhibits its kinase activity, and suppresses the proliferation of cancer cells by down-regulating phosphorylation signaling pathways including MAPK/ERK, JAK2/STAT3, and PI3K/Akt.

CELL DEATH & DISEASE (2021)

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Article Multidisciplinary Sciences

Regulatory T cells promote cancer immune-escape through integrin αvβ8-mediated TGF-β activation

Alexandra Laine et al.

Summary: The presence of TGF beta in the tumor microenvironment is a significant cancer immune-escape mechanism. This study shows that regulatory T cells work in concert with cancer cells to produce bioactive TGF beta, creating an immunosuppressive micro-environment. The activation of TGF beta by Treg cells through the expression of avb8 integrin’s b8 chain is necessary for tumor growth.

NATURE COMMUNICATIONS (2021)

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Review Oncology

The Multifaceted Roles of EGFL7 in Cancer and Drug Resistance

Beate Heissig et al.

Summary: Cancer growth and metastasis rely on interactions with the extracellular matrix, with EGFL7 and beta 3 integrin playing crucial roles in processes such as angiogenesis, ECM stiffness alterations, cellular adhesion, migration, and drug resistance. The signaling axis formed by EGFL7 and beta 3 integrin is identified as a key mediator in tumor metastasis and drug resistance. Research on these proteins provides insights into potential targets for anti-cancer strategies.

CANCERS (2021)

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Article Oncology

Integrin αvβ3 Engagement Regulates Glucose Metabolism and Migration through Focal Adhesion Kinase (FAK) and Protein Arginine Methyltransferase 5 (PRMT5) in Glioblastoma Cells

Pulin Che et al.

Summary: The study investigates the role of integrin alpha v beta 3 engagement with its ligand in metabolic reprogramming in glioblastoma cells. It was found that integrin alpha v beta 3 increases glucose uptake and aerobic glycolysis, while decreasing mitochondrial oxidative phosphorylation. The interaction of integrin alpha v beta 3 with osteopontin plays a crucial role in promoting metabolic shift towards glycolysis and inhibiting mitochondrial oxidative phosphorylation, leading to changes in cell behavior such as migration and invasion.

CANCERS (2021)

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Article Chemistry, Medicinal

Discovery of antiproliferative and anti-FAK inhibitory activity of 1,2,4-triazole derivatives containing acetamido carboxylic acid skeleton

Muhamad Mustafa et al.

Summary: Small molecule inhibitors of focal adhesion kinase have shown promising therapeutic potential in cancer treatment. Among the 1,2,4-triazole derivatives tested, compounds 3c and 3d demonstrated the strongest antiproliferative activity, with 3d being identified as a potent preclinical candidate for cancer treatment.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2021)

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Article Hematology

Efficacy and safety of bosutinib versus imatinib for newly diagnosed chronic myeloid leukemia in the Asian subpopulation of the phase 3 BFORE trial

Charles Chuah et al.

Summary: The study showed that bosutinib had better major molecular response rate and complete cytogenetic response rate compared to imatinib in both Asian and non-Asian patients. Treatment-emergent adverse events in both subpopulations were consistent with the primary BFORE results.

INTERNATIONAL JOURNAL OF HEMATOLOGY (2021)

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Article Chemistry, Medicinal

New Thyrointegrin αvβ3 Antagonist with a Scalable Synthesis, Brain Penetration, and Potent Activity against Glioblastoma Multiforme

Bruce A. Hay et al.

Summary: The newly discovered fb-PMT can significantly reduce GBM tumor growth and viability by up to 98%, is suitable for large-scale synthesis, and can be analyzed using mass spectrometry-based detection.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Article Oncology

Copanlisib plus rituximab versus placebo plus rituximab in patients with relapsed indolent non-Hodgkin lymphoma (CHRONOS-3): a double-blind, randomised, placebo-controlled, phase 3 trial

Matthew J. Matasar et al.

Summary: Copanlisib plus rituximab significantly improved progression-free survival in patients with relapsed indolent non-Hodgkin lymphoma compared with placebo plus rituximab, with the most common grade 3-4 adverse events being hyperglycemia and hypertension.

LANCET ONCOLOGY (2021)

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Article Oncology

Targeting integrin αvβ3 with indomethacin inhibits patient-derived xenograft tumour growth and recurrence in oesophageal squamous cell carcinoma

Fangfang Liu et al.

Summary: High ITGAV levels are associated with poor prognosis in ESCC patients. Targeting ITGAV may be a rational approach for preventing ESCC recurrence. Indomethacin can attenuate ESCC growth and enhance anti-tumour immune responses by binding to ITGAV.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

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Article Oncology

Exosomal integrins and their influence on pancreatic cancer progression and metastasis

Ilaria Casari et al.

Summary: Pancreatic cancer, as one of the most lethal types of cancer, is difficult to diagnose and treat in time. The appearance of metastasis is dreaded by every cancer patient.

CANCER LETTERS (2021)

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Article Oncology

Phosphoproteomics Identifies PI3K Inhibitor-selective Adaptive Responses in Pancreatic Cancer Cell Therapy and Resistance

Celia Cintas et al.

Summary: The PI3K pathway is highly active in human cancers and its inhibition is a potential therapeutic strategy for pancreatic cancer. However, different isoform-selective PI3K inhibitors have varying effects, with some leading to reactivation of downstream signaling. Combining inhibitors with different isoform selectivity may prevent the induction of compensatory signals and have a synergistic effect on cell survival.

MOLECULAR CANCER THERAPEUTICS (2021)

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Review Genetics & Heredity

A Potential Role for Integrin-Linked Kinase in Colorectal Cancer Growth and Progression via Regulating Senescence and Immunity

Saleh Almasabi et al.

Summary: ILK is implicated in inflammation and tumorigenesis in the colon, with potential therapeutic implications in CRC. It may play a role in senescence and immunity, but further research is needed to determine its specific actions in CRC. Triggering immune responses against cancer in CRC through activation of TLRs and combining with ILK inhibition could be a promising approach.

FRONTIERS IN GENETICS (2021)

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Article Oncology

A Phase I Trial of Dasatinib and Osimertinib in TKI Naive Patients With Advanced EGFR-Mutant Non-Small-Cell Lung Cancer

Chul Kim et al.

Summary: The study investigated the efficacy and safety of osimertinib and dasatinib combination therapy in TKI-naive EGFR-mutant NSCLC, showing anticancer activity but limited by chronic toxicities attributed mainly to dasatinib.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

Deregulation of CLTC interacts with TFG, facilitating osteosarcoma via the TGF-beta and AKT/mTOR signaling pathways

Li Shijie et al.

Summary: High expression of CLTC is an independent prognostic factor for patients with osteosarcoma, and its down-regulation exerts tumor-suppressive effects, possibly through the SP1/CLTC/TFG axis.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

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Article Oncology

Protective function of interleukin-22 in pulmonary fibrosis

Peiyu Gu et al.

Summary: IPF is a chronic lung disease with unknown cause, and the role of IL-22 in inhibiting TGF-beta 1 signaling pathway could be protective against pulmonary fibrosis. IL-22 shows potential as a therapeutic target for treating IPF.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

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Article Oncology

Rebalancing TGF-β/Smad7 signaling via Compound kushen injection in hepatic stellate cells protects against liver fibrosis and hepatocarcinogenesis

Yang Yang et al.

Summary: Through meta-analysis and preclinical experiments, this study revealed that Compound kushen injection (CKI) has anti-fibrotic and anti-hepatocarcinogenesis effects by rebalancing TGF-beta/Smad7 signaling to protect against liver fibrosis and hepatocarcinogenesis in both preclinical and clinical studies. CKI could be a potential candidate for the treatment of hepatic fibrosis and related oncogenesis.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

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Review Oncology

MYC protein interactors in gene transcription and cancer

Corey Lourenco et al.

Summary: The transcription factor and oncoprotein MYC plays a critical role in many human cancers, with its ability to interact with multiple proteins enabling it to regulate key control points of gene transcription. This 'coalition model' of protein interactions allows MYC to function as a potent oncoprotein, and provides a potential therapeutic target for impeding MYC oncogenesis.

NATURE REVIEWS CANCER (2021)

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Review Biochemistry & Molecular Biology

Targeting TGFβ signal transduction for cancer therapy

Sijia Liu et al.

Summary: TGF beta family members are cytokines with diverse effects on cell fate regulation during development and tissue homeostasis. Dysregulation of TGF beta signaling can lead to developmental disorders and diseases, including cancer. TGF beta plays a dichotomous role in cancer progression, acting as a tumor suppressor in early stages and a tumor promoter in late stages, with effects on proliferation, differentiation, apoptosis, metastasis, and the tumor microenvironment.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Oncology

Secretory Mucin SAC Promotes Neoplastic Progression by Augmenting KLF4-Mediated Pancreatic Cancer Cell Sternness

Koelina Ganguly et al.

Summary: Genetic ablation of secreted mucin 5AC (MUC5AC) in a murine model significantly delays neoplastic onset and PanIN lesion progression in pancreatic cancer, with a reduction in cancer stem cell markers and tumor formation frequency. Mechanistically, MUC5AC potentiates oncogenic signaling through integrin ow135, pSrc (Y416), and pSTAT3 (Y705), leading to enrichment of the self-renewing CSC population. These findings highlight the crucial role of MUC5AC in promoting cancer cell sternness during pancreatic tumorigenesis and suggest it as a potential therapeutic target.

CANCER RESEARCH (2021)

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Review Immunology

Lactate modulation of immune responses in inflammatory versus tumour microenvironments

Michelangelo Certo et al.

Summary: The microenvironments of cancerous tissues and tissues affected by chronic inflammatory diseases exhibit different immune states but similar metabolic states. Understanding the metabolic signature allows for therapeutic intervention to reset metabolite availability and correct dysregulated immune states.

NATURE REVIEWS IMMUNOLOGY (2021)

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Article Gastroenterology & Hepatology

Development of resistance to FAK inhibition in pancreatic cancer is linked to stromal depletion

Hong Jiang et al.

GUT (2020)

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Article Biochemistry & Molecular Biology

ITGB4-mediated metabolic reprogramming of cancer-associated fibroblasts

Jin Sol Sung et al.

ONCOGENE (2020)

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Article Oncology

Deubiquitinating enzyme USP10 promotes hepatocellular carcinoma metastasis through deubiquitinating and stabilizing Smad4 protein

Tao Yuan et al.

MOLECULAR ONCOLOGY (2020)

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Article Biochemistry & Molecular Biology

Interaction between laminin-5γ2 and integrin β1 promotes the tumor budding of colorectal cancer via the activation of Yes-associated proteins

Bijiao Zhou et al.

ONCOGENE (2020)

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Article Chemistry, Multidisciplinary

A novel biphenyl compound IMB-S7 ameliorates hepatic fibrosis in BDL rats by suppressing Sp1-mediated integrin αv expression

Na Zhang et al.

ACTA PHARMACOLOGICA SINICA (2020)

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Article Oncology

Integrin β4-Targeted Cancer Immunotherapies Inhibit Tumor Growth and Decrease Metastasis

Shasha Ruan et al.

CANCER RESEARCH (2020)

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Review Biochemistry & Molecular Biology

Integrin Signaling in Glioma Pathogenesis: From Biology to Therapy

Aleksandra Ellert-Miklaszewska et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Oncology

Phase 2 study of the focal adhesion kinase inhibitor defactinib (VS-6063) in previously treated advanced KRAS mutant non-small cell lung cancer

David E. Gerber et al.

LUNG CANCER (2020)

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Review Genetics & Heredity

Integrin ανβ6 Protein Expression and Prognosis in Solid Tumors: A Meta-Analysis

Alexandra Desnoyers et al.

MOLECULAR DIAGNOSIS & THERAPY (2020)

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Review Cell Biology

Controlling Immunity and Inflammation through Integrin-Dependent Regulation of TGF-β

Martijn Nolte et al.

TRENDS IN CELL BIOLOGY (2020)

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Article Oncology

Time course and management of key adverse events during the randomized phase III SOLAR-1 study of PI3K inhibitor alpelisib plus fulvestrant in patients with HR-positive advanced breast cancer

H. S. Rugo et al.

ANNALS OF ONCOLOGY (2020)

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Article Biology

T-cell co-stimulation in combination with targeting FAK drives enhanced anti-tumor immunity

Marta Canel et al.

ELIFE (2020)

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Article Oncology

ASCEND: Phase III, Randomized Trial of Acalabrutinib Versus Idelalisib Plus Rituximab or Bendamustine Plus Rituximab in Relapsed or Refractory Chronic Lymphocytic Leukemia

Paolo Ghia et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

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Article Oncology

Extracellular Vesicles from Cancer-Associated Fibroblasts Containing Annexin A6 Induces FAK-YAP Activation by Stabilizing β1 Integrin, Enhancing Drug Resistance

Tomoyuki Uchihara et al.

CANCER RESEARCH (2020)

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Article Chemistry, Medicinal

Dual Targeting of Norepinephrine Transporter (NET) Function and Thyrointegrin ανβ3 Receptors in the Treatment of Neuroblastoma

Ozlem Ozen Karakus et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

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Article Oncology

Upregulated expression and function of theα4β1 integrin in multiple myeloma cells resistant to bortezomib

Silvia Sevilla-Movilla et al.

JOURNAL OF PATHOLOGY (2020)

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Article Biochemistry & Molecular Biology

Metabolic reprogramming sustains cancer cell survival following extracellular matrix detachment

Hitoshi Endo et al.

REDOX BIOLOGY (2020)

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Article Cell Biology

EDIL3 promotes epithelial-mesenchymal transition and paclitaxel resistance through its interaction with integrin αVβ3in cancer cells

J. Gasca et al.

CELL DEATH DISCOVERY (2020)

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Review Biotechnology & Applied Microbiology

The Roles of Integrin α5β1 in Human Cancer

Jianbing Hou et al.

ONCOTARGETS AND THERAPY (2020)

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Article Oncology

Pregnancy-specific glycoprotein 9 acts as both a transcriptional target and a regulator of the canonical TGF-β/Smad signaling to drive breast cancer progression

Ying-Ying Liu et al.

CLINICAL AND TRANSLATIONAL MEDICINE (2020)

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Review Oncology

TGF-β signaling in liver metastasis

Dieuwke L. Marvin et al.

CLINICAL AND TRANSLATIONAL MEDICINE (2020)

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Article Cell Biology

Exosome-derived ENO1 regulates integrin α6β4 expression and promotes hepatocellular carcinoma growth and metastasis

Keqiu Jiang et al.

CELL DEATH & DISEASE (2020)

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Article Oncology

Integrin αvβ8 serves as a Novel Marker of Poor Prognosis in Colon Carcinoma and Regulates Cell Invasiveness through the Activation of TGF-β1

Mingliang Zhou et al.

JOURNAL OF CANCER (2020)

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Article Biochemistry & Molecular Biology

Integrin α6β4-Src-AKT signaling induces cellular senescence by counteracting apoptosis in irradiated tumor cells and tissues

Seung Hee Jung et al.

CELL DEATH AND DIFFERENTIATION (2019)

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Article Gastroenterology & Hepatology

A Transforming Growth Factor-β and H19 Signaling Axis in Tumor-Initiating Hepatocytes That Regulates Hepatic Carcinogenesis

Jinqiang Zhang et al.

HEPATOLOGY (2019)

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Article Cell Biology

AhR ligand aminoflavone suppresses α6-integrin-Src-Akt signaling to attenuate tamoxifen resistance in breast cancer cells

Petreena S. Campbell et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Article Biochemistry & Molecular Biology

Prostate cancer sheds the αvβ3 integrin in vivo through exosomes

Shiv Ram Krishn et al.

MATRIX BIOLOGY (2019)

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Review Oncology

Integrin as a Molecular Target for Anti-cancer Approaches in Lung Cancer

Nithikoon Aksorn et al.

ANTICANCER RESEARCH (2019)

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Article Oncology

Cancer-associated fibroblast (CAF)-derived IL32 promotes breast cancer cell invasion and metastasis via integrin β3-p38 MAPK signalling

Siyang Wen et al.

CANCER LETTERS (2019)

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Article Medicine, Research & Experimental

Cullin5 deficiency promotes small-cell lung cancer metastasis by stabilizing integrin β1

Gaoxiang Zhao et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

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Article Radiology, Nuclear Medicine & Medical Imaging

68Ga-DOTA-E[c(RGDfK)]2 PET Imaging of SHARPIN-Regulated Integrin Activity in Mice

Riikka Siitonen et al.

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A Multicenter Phase 1 Study of EMD 525797 (DI17E6), a Novel Humanized Monoclonal Antibody Targeting αv Integrins, in Progressive Castration-resistant Prostate Cancer with Bone Metastases After Chemotherapy

Manfred Wirth et al.

EUROPEAN UROLOGY (2014)

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Article Obstetrics & Gynecology

Role for the endometrial epithelial protein MFG-E8 and its receptor integrin αvβ3 in human implantation: results of an in vitro trophoblast attachment study using established human cell lines

Carla Schmitz et al.

FERTILITY AND STERILITY (2014)

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Article Oncology

Inhibition of α4β1 integrin increases ovarian cancer response to carboplatin

Jennifer M. Scalici et al.

GYNECOLOGIC ONCOLOGY (2014)

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Article Immunology

The Transcription Factor IRF8 Activates Integrin-Mediated TGF-β Signaling and Promotes Neuroinflammation

Yuko Yoshida et al.

IMMUNITY (2014)

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Article Surgery

The fate of internalized α5 integrin is regulated by matrix-capable fibronectin

Henry C. Hsia et al.

JOURNAL OF SURGICAL RESEARCH (2014)

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Article Oncology

Therapeutic Targeting of Integrin αvβ6 in Breast Cancer

Kate M. Moore et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2014)

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Article Oncology

Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial

Roger Stupp et al.

LANCET ONCOLOGY (2014)

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Article Cell Biology

An integrin β3-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition

Laetitia Seguin et al.

NATURE CELL BIOLOGY (2014)

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Article Biochemistry & Molecular Biology

Oncogenic targeting of BRM drives malignancy through C/EBPβ-dependent induction of α5 integrin

L. Damiano et al.

ONCOGENE (2014)

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Article Multidisciplinary Sciences

Microenvironmental Stiffness Enhances Glioma Cell Proliferation by Stimulating Epidermal Growth Factor Receptor Signaling

Vaibhavi Umesh et al.

PLOS ONE (2014)

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Article Multidisciplinary Sciences

Patient-derived models of acquired resistance can identify effective drug combinations for cancer

Adam S. Crystal et al.

SCIENCE (2014)

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Article Pathology

Integrins and their ligands are expressed in non-small cell lung cancer but not correlated with parameters of disease progression

Christine Boeger et al.

VIRCHOWS ARCHIV (2014)

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Article Oncology

Phase Ib safety and pharmacokinetic study of volociximab, an anti-α5β1 integrin antibody, in combination with carboplatin and paclitaxel in advanced non-small-cell lung cancer

B. Besse et al.

ANNALS OF ONCOLOGY (2013)

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Article Hematology

EGFL7 ligates αvβ3 integrin to enhance vessel formation

Iva Nikolic et al.

BLOOD (2013)

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Article Oncology

Integrin α3β1 regulates tumor cell responses to stromal cells and can function to suppress prostate cancer metastatic colonization

Afshin Varzavand et al.

CLINICAL & EXPERIMENTAL METASTASIS (2013)

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Article Oncology

Dasatinib plus Capecitabine for Advanced Breast Cancer: Safety and Efficacy in Phase I Study CA180004

George Somlo et al.

CLINICAL CANCER RESEARCH (2013)

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Article Medicine, Research & Experimental

GLI1 regulates a novel neuropilin-2/61 integrin based autocrine pathway that contributes to breast cancer initiation

Hira Lal Goel et al.

EMBO MOLECULAR MEDICINE (2013)

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Article Oncology

Combination therapy of cilengitide with belotecan against experimental glioblastoma

Young-Hoon Kim et al.

INTERNATIONAL JOURNAL OF CANCER (2013)

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Article Oncology

Tspan8, CD44v6 and alpha6beta4 are biomarkers of migrating pancreatic cancer-initiating cells

Haobin Wang et al.

INTERNATIONAL JOURNAL OF CANCER (2013)

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Article Cell Biology

CCM1-ICAP-1 complex controls β1 integrin-dependent endothelial contractility and fibronectin remodeling

Eva Faurobert et al.

JOURNAL OF CELL BIOLOGY (2013)

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Review Cell Biology

Integrin inactivators: balancing cellular functions in vitro and in vivo

Daniel Bouvard et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)

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Article Oncology

In vitro study of combined cilengitide and radiation treatment in breast cancer cell lines

Tim Lautenschlaeger et al.

RADIATION ONCOLOGY (2013)

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Article Oncology

Integrin α5β1, the Fibronectin Receptor, as a Pertinent Therapeutic Target in Solid Tumors

Florence Schaffner et al.

Cancers (2013)

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Article Oncology

Integrin α1 subunit is up-regulated in colorectal cancer

Salah Boudjadi et al.

BIOMARKER RESEARCH (2013)

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Article Oncology

Integrin α5β1 Plays a Critical Role in Resistance to Temozolomide by Interfering with the p53 Pathway in High-Grade Glioma

Hana Janouskova et al.

CANCER RESEARCH (2012)

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Article Oncology

Enhancing the effectiveness of androgen deprivation in prostate cancer by inducing Filamin A nuclear localization

Benjamin A. Mooso et al.

ENDOCRINE-RELATED CANCER (2012)

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Article Biotechnology & Applied Microbiology

Volociximab in cancer

Salah Almokadem et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2012)

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Article Oncology

Involvement of the TGFβ pathway in the regulation of α5β1 integrins by caveolin-1 in human glioblastoma

Erika C. Cosset et al.

INTERNATIONAL JOURNAL OF CANCER (2012)

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Article Oncology

A phase I study of continuous infusion cilengitide in patients with solid tumors

Peter H. O'Donnell et al.

INVESTIGATIONAL NEW DRUGS (2012)

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Article Biochemistry & Molecular Biology

α2β1 Integrin Promotes Chemoresistance against Doxorubicin in Cancer Cells through Extracellular Signal-regulated Kinase (ERK)

Dalila Naci et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

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Article Cell Biology

Rab5c promotes AMAP1-PRKD2 complex formation to enhance β1 integrin recycling in EGF-induced cancer invasion

Yasuhito Onodera et al.

JOURNAL OF CELL BIOLOGY (2012)

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Article Cell Biology

Cdc42 promotes transendothelial migration of cancer cells through β1 integrin

Nicolas Reymond et al.

JOURNAL OF CELL BIOLOGY (2012)

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Article Medicine, Research & Experimental

β1 Integrin/FAK/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy

Iris Eke et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

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Article Oncology

Safety, Pharmacokinetic, and Pharmacodynamic Phase I Dose-Escalation Trial of PF-00562271, an Inhibitor of Focal Adhesion Kinase, in Advanced Solid Tumors

Jeffrey R. Infante et al.

JOURNAL OF CLINICAL ONCOLOGY (2012)

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Review Medicine, Research & Experimental

RGD-Based Strategies To Target Alpha(v) Beta(3) Integrin in Cancer Therapy and Diagnosis

Fabienne Danhier et al.

MOLECULAR PHARMACEUTICS (2012)

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Article Cell Biology

MYC suppresses cancer metastasis by direct transcriptional silencing of αv and β3 integrin subunits

Hong Liu et al.

NATURE CELL BIOLOGY (2012)

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Review Oncology

Treatment of HER2-positive breast cancer: current status and future perspectives

Carlos L. Arteaga et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2012)

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Article Oncology

A randomized phase II study of cilengitide (EMD 121974) in patients with metastatic melanoma

Kevin B. Kim et al.

MELANOMA RESEARCH (2012)

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Article Biochemistry & Molecular Biology

CD49f and CD61 identify Her2/neu-induced mammary tumor-initiating cells that are potentially derived from luminal progenitors and maintained by the integrin-TGFβ signaling

P-K Lo et al.

ONCOGENE (2012)

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Article Oncology

A phase I study of dasatinib and weekly paclitaxel for metastatic breast cancer

M. N. Fornier et al.

ANNALS OF ONCOLOGY (2011)

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Article Oncology

A randomised, phase II study of intetumumab, an anti-αv-integrin mAb, alone and with dacarbazine in stage IV melanoma

S. O'Day et al.

BRITISH JOURNAL OF CANCER (2011)

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Article Oncology

Receptor Tyrosine Kinases and TLR/IL1 Rs Unexpectedly Activate Myeloid Cell PI3Kγ, A Single Convergent Point Promoting Tumor Inflammation and Progression

Michael C. Schmid et al.

CANCER CELL (2011)

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Article Oncology

The Integrin αvβ3-5 Ligand MFG-E8 Is a p63/p73 Target Gene in Triple-Negative Breast Cancers but Exhibits Suppressive Functions in ER+ and erbB2+ Breast Cancers

Chuanwei Yang et al.

CANCER RESEARCH (2011)

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Review Pharmacology & Pharmacy

Integrin α3β1 as a breast cancer target

Sita Subbaram et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2011)

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Article Oncology

A phase II, single-arm study of the anti-α5β1 integrin antibody volociximab as monotherapy in patients with platinum-resistant advanced epithelial ovarian or primary peritoneal cancer

Katherine M. Bell-McGuinn et al.

GYNECOLOGIC ONCOLOGY (2011)

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Article Cell Biology

Integrin α5β1 facilitates cancer cell invasion through enhanced contractile forces

Claudia Tanja Mierke et al.

JOURNAL OF CELL SCIENCE (2011)

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Article Cell Biology

SHARPIN is an endogenous inhibitor of β1-integrin activation

Juha K. Rantala et al.

NATURE CELL BIOLOGY (2011)

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Article Oncology

Cilengitide induces autophagy-mediated cell death in glioma cells

Stephanie L. Lomonaco et al.

NEURO-ONCOLOGY (2011)

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Article Biochemistry & Molecular Biology

β1 integrin controls EGFR signaling and tumorigenic properties of lung cancer cells

V. Morello et al.

ONCOGENE (2011)

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Article Multidisciplinary Sciences

Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancer

Roya Navab et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

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Article Oncology

beta 1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib

Catherine Huang et al.

BREAST CANCER RESEARCH (2011)

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Article Biochemistry & Molecular Biology

α5β1-Integrin Expression Is Essential for Tumor Progression in Experimental Lung Cancer

Jesse Roman et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2010)

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Article Hematology

Spleen tyrosine kinase inhibition prevents chemokine- and integrin-mediated stromal protective effects in chronic lymphocytic leukemia

Maike Buchner et al.

BLOOD (2010)

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Article Oncology

A Randomized Phase 2 Study of Etaracizumab, a Monoclonal Antibody Against Integrin αvβ3, ± Dacarbazine in Patients With Stage IV Metastatic Melanoma

Peter Hersey et al.

CANCER (2010)

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Article Oncology

Combined anti-angiogenic therapy against VEGF and integrin alphabeta in an orthotopic model of ovarian cancer

Tae Jin Kim et al.

CANCER BIOLOGY & THERAPY (2010)

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Article Oncology

Anti-αv Integrin Monoclonal Antibody Intetumumab Enhances the Efficacy of Radiation Therapy and Reduces Metastasis of Human Cancer Xenografts in Nude Rats

Shoucheng Ning et al.

CANCER RESEARCH (2010)

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Article Cell & Tissue Engineering

Integrin Alpha 6 Regulates Glioblastoma Stem Cells

Justin D. Lathia et al.

CELL STEM CELL (2010)

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Review Cell Biology

The Laminin Binding Integrin α6β1 in Prostate Cancer Perineural Invasion

Isis C. Sroka et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2010)

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Review Biochemistry & Molecular Biology

Integrin-mediated function of Rab GTPases in cancer progression

Dhatchayini Subramani et al.

MOLECULAR CANCER (2010)

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Article Medicine, Research & Experimental

RGD-Conjugated Dendrimer-Modified Gold Nanorods for in Vivo Tumor Targeting and Photothermal Therapy

Zhiming Li et al.

MOLECULAR PHARMACEUTICS (2010)

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Article Cell Biology

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

Joon-Il Jun et al.

NATURE CELL BIOLOGY (2010)

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Review Biochemistry & Molecular Biology

Chemokines and chemokine receptors: new insights into cancer-related inflammation

Gwendal Lazennec et al.

TRENDS IN MOLECULAR MEDICINE (2010)

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Review Oncology

Integrins in cancer: biological implications and therapeutic opportunities

Jay S. Desgrosellier et al.

NATURE REVIEWS CANCER (2010)

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Article Oncology

Negative Regulation of β4 Integrin Transcription by Homeodomain-Interacting Protein Kinase 2 and p53 Impairs Tumor Progression

Giulia Bon et al.

CANCER RESEARCH (2009)

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Article Cell Biology

The reverse Warburg effect Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

Stephanos Pavlides et al.

CELL CYCLE (2009)

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Article Oncology

Radiation sensitization of glioblastoma by cilengitide has unanticipated schedule-dependency

Tom Mikkelsen et al.

INTERNATIONAL JOURNAL OF CANCER (2009)

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Article Cell Biology

SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of β1-integrin

Dominique T. Brandt et al.

NATURE CELL BIOLOGY (2009)

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Review Cell Biology

Integrins: masters and slaves of endocytic transport

Patrick T. Caswell et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)

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Article Oncology

Rapid chemotherapy-induced acute endothelial progenitor cell mobilization: Implications for antiangiogenic drugs as chemosensitizing agents

Yuval Shaked et al.

CANCER CELL (2008)

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Article Oncology

Loss of integrin α1β1 ameliorates Kras-induced lung cancer

Ines Macias-Perez et al.

CANCER RESEARCH (2008)

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Article Oncology

β1 integrin inhibition dramatically enhances radiotherapy efficacy in human breast cancer xenografts

Catherine C. Park et al.

CANCER RESEARCH (2008)

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Article Oncology

Volociximab, a Chimeric Monoclonal Antibody that Specifically Binds α5β1 Integrin: A Phase I, Pharmacokinetic, and Biological Correlative Study

Alejandro D. Ricart et al.

CLINICAL CANCER RESEARCH (2008)

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Article Oncology

Angiostatic activity of obtustatin as α1β1 integrin inhibitor in experimental melanoma growth

Meghan C. Brown et al.

INTERNATIONAL JOURNAL OF CANCER (2008)

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Article Cell Biology

Cell adaptive response to extracellular matrix density is controlled by ICAP-1-dependent β1-integrin affinity

Angelique Millon-Fremillon et al.

JOURNAL OF CELL BIOLOGY (2008)

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Article Oncology

Phase I clinical trial of cilengitide in children with refractory brain tumors: Pediatric brain tumor consortium study PBTC-012

Tobey J. MacDonald et al.

JOURNAL OF CLINICAL ONCOLOGY (2008)

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Article Oncology

Randomized Phase II Study of Cilengitide, an Integrin-Targeting Arginine-Glycine-Aspartic Acid Peptide, in Recurrent Glioblastoma Multiforme

David A. Reardon et al.

JOURNAL OF CLINICAL ONCOLOGY (2008)

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Article Oncology

Cilengitide induces cellular detachment and apoptosis in endothelial and glioma cells mediated by inhibition of FAK/src/AKT pathway

Leticia Oliveira-Ferrer et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2008)

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Article Immunology

TGF-β inhibits IL-2 production and promotes cell cycle arrest in TCR-activated effector/memory T cells in the presence of sustained TCR signal transduction

Lopamudra Das et al.

JOURNAL OF IMMUNOLOGY (2008)

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Article Biochemistry & Molecular Biology

Structural basis for the interaction between the cytoplasmic domain of the hyaluronate receptor layilin and the talin F3 subdomain

Kate L. Wegener et al.

JOURNAL OF MOLECULAR BIOLOGY (2008)

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Article Multidisciplinary Sciences

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

Liang Zhou et al.

NATURE (2008)

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Review Plant Sciences

The regulatory RAB and ARF GTPases for vesicular trafficking

Erik Nielsen et al.

PLANT PHYSIOLOGY (2008)

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Article Oncology

Tumor-Selective Response to Antibody-Mediated Targeting of αvβ3 Integrin in Ovarian Cancer

Charles N. Landen et al.

NEOPLASIA (2008)

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Article Immunology

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

Yukiko Tone et al.

NATURE IMMUNOLOGY (2008)

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Article Oncology

Phase I and pharmacokinetic study of etaracizumab (Abegrin™), a humanized monoclonal antibody against αvβ3 integrin receptor, in patients with advanced solid tumors

Catherine Delbaldo et al.

INVESTIGATIONAL NEW DRUGS (2008)

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Review Biotechnology & Applied Microbiology

Modifying IGF1 activity: an approach to treat endocrine disorders, atherosclerosis and cancer

David R. Clemmons

NATURE REVIEWS DRUG DISCOVERY (2007)

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Article Cell Biology

Rab25 associates with α5β1 integrin to promote invasive migration in 3D microenvironments

Patrick T. Caswell et al.

DEVELOPMENTAL CELL (2007)

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Review Immunology

Integrin modulation and signaling in leukocyte adhesion and migration

David M. Rose et al.

IMMUNOLOGICAL REVIEWS (2007)

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Article Multidisciplinary Sciences

Fibrinogen inhibits neurite outgrowth via β3 integrin-mediated phosphorylation of the EGF receptor

Christian Schachtrup et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

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Article Multidisciplinary Sciences

Integrin all regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells

Chang-Qi Zhu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

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Article Oncology

Overexpression of the αvβ6 integrin in cervical squamous cell carcinoma is a prognostic factor for decreased survival

S. Hazelbag et al.

JOURNAL OF PATHOLOGY (2007)

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Article Oncology

A peptide selected by biopanning identifies the integrin αvβ6 as a prognostic biomarker for nonsmall cell lung cancer

Anissa N. Elayadi et al.

CANCER RESEARCH (2007)

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Article Biochemistry & Molecular Biology

Constitutively activated Stat3 induces tumorigenesis and enhances cell motility of prostate epithelial cells through integrin β6

Janeen Azare et al.

MOLECULAR AND CELLULAR BIOLOGY (2007)

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Article Gastroenterology & Hepatology

Determination of the ligand-binding specificities of the α2β1 and α1β1 integrins in a novel 3-dimensional in vitro model of pancreatic cancer

John J. Grzesiak et al.

PANCREAS (2007)

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Review Biotechnology & Applied Microbiology

The integrins

Yoshikazu Takada et al.

GENOME BIOLOGY (2007)

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Article Biochemistry & Molecular Biology

Cooperation between Myc and YY1 provides novel silencing transcriptional targets of alpha 3 beta 1-integrin in tumour cells

F. de Nigris et al.

ONCOGENE (2007)

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Article Biochemistry & Molecular Biology

The Rab4A effector protein Rabip4 is involved in migration of NIH 3T3 fibroblasts

Jelena Vukmirica et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

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Article Biochemistry & Molecular Biology

β4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis

Wenjun Guo et al.

CELL (2006)

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Article Medicine, Research & Experimental

Blocking the α4 integrin-paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site

CC Féral et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

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Article Biochemistry & Molecular Biology

The molecular basis of filamin binding to integrins and competition with talin

T Kiema et al.

MOLECULAR CELL (2006)

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Article Pathology

Increased expression of integrin αvβ5 induces the myofibroblastic differentiation of dermal fibroblasts

Y Asano et al.

AMERICAN JOURNAL OF PATHOLOGY (2006)

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Review Cell Biology

Integrin trafficking and the control of cell migration

PT Caswell et al.

TRAFFIC (2006)

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Article Oncology

Biological and molecular properties of a new αvβ3/αvβ5 integrin antagonist

L Belvisi et al.

MOLECULAR CANCER THERAPEUTICS (2005)

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Article Biochemistry & Molecular Biology

Upregulation of a functional form of the β4 integrin subunit in colorectal cancers correlates with c-Myc expression

HH Ni et al.

ONCOGENE (2005)

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Article Cell Biology

Cbl-mediated ubiquitination of α5 integrin subunit mediates fibronectin-dependent osteoblast detachment and apoptosis induced by FGFR2 activation

K Kaabeche et al.

JOURNAL OF CELL SCIENCE (2005)

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Review Cell Biology

Focal adhesion kinase: In command and control of cell motility

SK Mitra et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)

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Article Multidisciplinary Sciences

The endothelial-cell-derived secreted factor Egfl7 regulates vascular tube formation

LH Parker et al.

NATURE (2004)

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Review Biochemistry & Molecular Biology

Modulation of prostate cancer growth in bone microenvironments

M Edlund et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2004)

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Review Hematology

Integrins: dynamic scaffolds for adhesion and signaling in platelets

SJ Shattil et al.

BLOOD (2004)

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Article Oncology

CNTO 95, a fully human monoclonal antibody that inhibits αv integrins, has antitumor and antiangiogenic activity in vivo

M Trikha et al.

INTERNATIONAL JOURNAL OF CANCER (2004)

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Review Cell Biology

Roles of αv integrins in vascular biology and pulmonary pathology

D Sheppard

CURRENT OPINION IN CELL BIOLOGY (2004)

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Article Biochemistry & Molecular Biology

VE-statin, an endothelial repressor of smooth muscle cell migration

F Soncin et al.

EMBO JOURNAL (2003)

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Article Biochemistry & Molecular Biology

N-Myc overexpression leads to decreased β1 integrin expression and increased apoptosis in human neuroblastoma cells

CM van Golen et al.

ONCOGENE (2003)

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Article Biochemistry & Molecular Biology

Disruption of focal adhesions by integrin cytoplasmic domain-associated protein-1α

D Bouvard et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

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Article Multidisciplinary Sciences

Type Iγ phosphatidylinositol phosphate kinase targets and regulates focal adhesions

K Ling et al.

NATURE (2002)

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Article Immunology

The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease

MF Neurath et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2002)

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Article Oncology

Different phenotypes in human prostate cancer:: α6 or α3 integrin in cell-extracellular adhesion sites

M Schmelz et al.

NEOPLASIA (2002)

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Article Cell Biology

The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-β1

DZ Mu et al.

JOURNAL OF CELL BIOLOGY (2002)

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Article Cell Biology

Serum response factor is crucial for actin cytoskeletal organization and focal adhesion assembly in embryonic stem cells

G Schratt et al.

JOURNAL OF CELL BIOLOGY (2002)

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Review Oncology

Integrins and prostate cancer metastases

M Fornaro et al.

CANCER AND METASTASIS REVIEWS (2001)

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Article Biochemistry & Molecular Biology

Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells

F Aoudjit et al.

ONCOGENE (2001)

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Article Immunology

Cutting edge:: TGF-β inhibits Th type 2 development through inhibition of GATA-3 expression

L Gorelik et al.

JOURNAL OF IMMUNOLOGY (2000)

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Article Pathology

Regulation of angiogenesis in vivo by ligation of integrin α5β1 with the central cell-binding domain of fibronectin

S Kim et al.

AMERICAN JOURNAL OF PATHOLOGY (2000)

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Review Biochemistry & Molecular Biology

Mechanisms of angiogenesis and arteriogenesis

P Carmeliet

NATURE MEDICINE (2000)

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Article Oncology

A phase II trial of GSK2256098 and trametinib in patients with advanced pancreatic ductal adenocarcinoma

Kyaw L. Aung et al.

Summary: The combination of GSK2256098 and trametinib showed good tolerability but was not effective in unselected advanced PDAC patients.

JOURNAL OF GASTROINTESTINAL ONCOLOGY

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