Loke zupa decoction attenuates bronchial EMT-mediated airway remodelling in chronic asthma through the PI3K-Akt/HIF-1a signaling pathway

Article Endocrinology & Metabolism

FAM83A promotes the progression and metastasis of human pancreatic neuroendocrine tumors by inducing the epithelial-mesenchymal transition via the PI3K/AKT and ERK pathways

B. Zhou et al.

Summary: FAM83A plays an important role in the progression and metastasis of pancreatic neuroendocrine tumors by inducing epithelial-mesenchymal transition via the activation of the ERK and PI3K/AKT pathways.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2023)

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Article Pharmacology & Pharmacy

Sphingosine-1-phosphate/TGF-beta axis drives epithelial mesenchymal transition in asthma-like disease

Maria A. Riemma et al.

Summary: This study found that S1P is involved in the EMT process of airway remodeling and plays a role in asthma-related airway dysfunction. Targeting the S1P/TGF-beta axis may hold promise as a therapeutic target for controlling airway dysfunction in asthma.

BRITISH JOURNAL OF PHARMACOLOGY (2022)

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Article Chemistry, Applied

Non-volatile compounds of Hyssopus cuspidatus Boriss and their antioxidant and antimicrobial activities

Kariyemu Aihaiti et al.

Summary: This study evaluated the chemical composition and bioactivities of Hyssopus cuspidatus and found that the ethyl acetate fraction exhibited antioxidant and antimicrobial activities. 64 compounds were identified through LC-MS/MS analysis, with phenolic compounds being the main components. 34 compounds were isolated, six of which were new and eighteen were discovered from H. cuspidatus for the first time. The major components, including rosmarinic acid, methyl rosmarinate, butyl rosmarinate, and salvigenin, were determined, and most of the isolated compounds showed significant or moderate antioxidant and antimicrobial activities.

FOOD CHEMISTRY (2022)

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Review Biochemistry & Molecular Biology

Corticosteroid resistance in asthma: Cellular and molecular mechanisms

Gaetano Caramori et al.

Summary: Inhaled glucocorticoids (GCs) are widely used to treat asthma patients. They prevent the activation of immune and inflammatory cells in the lungs and have significant effects on airway structure. However, some patients show poor asthma control even with high doses of GCs, which may be due to GC resistance.

MOLECULAR ASPECTS OF MEDICINE (2022)

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Article Reproductive Biology

DNMT3B attenuated the inhibition of TET3 on epithelial-mesenchymal transition in TGF-81-induced ovarian cancer by methylating the TET3 promoter

Zhongxue Ye et al.

Summary: This study investigates the effects of DNMT3B and TET3 on TGF-81-induced EMT in ovarian cancer cells. The results suggest that DNMT3B mitigates the suppression of TET3 on TGF-81-induced EMT by methylating the promoter region of TET3.

REPRODUCTIVE BIOLOGY (2022)

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Article Plant Sciences

Integrated systems pharmacology and transcriptomics to dissect the mechanisms of Loki Zupa decoction in the treatment of murine allergic asthma

Cong Xie et al.

Summary: In this study, the therapeutic effect of LKZP on ovalbumin-induced asthma was investigated. LKZP was found to reduce airway hyperresponsiveness, inflammation, and mucus hypersecretion in a mouse model. It also downregulated the expression of IgE, IL-4, IL-5, IL-13, and TNF-alpha, while promoting the expression of IFN-gamma. Systems pharmacology analysis identified key bioactive ingredients and targets of LKZP against asthma. Transcriptomic analysis revealed differentially expressed genes related to cytokine-cytokine receptor interactions and immune and inflammatory response pathways. NF-kappa B and HIF-1 signaling pathways were identified as candidate targets involved in the action of LKZP on allergic asthma. Experimental validation confirmed the inhibition of NF-kappa B and HIF-1 alpha activation by LKZP treatment.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Chemistry, Medicinal

Mahuang Decoction Attenuates Airway Inflammation and Remodeling in Asthma via Suppression of the SP1/FGFR3/PI3K/AKT Axis

Lina Wei et al.

Summary: This study found that Mahuang decoction (MHD) has a protective effect against asthma by suppressing the SP1/FGFR3/PI3K/AKT axis, which reduces airway inflammation and remodeling.

DRUG DESIGN DEVELOPMENT AND THERAPY (2022)

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Article Cell & Tissue Engineering

Hypoxic hUCMSC-derived extracellular vesicles attenuate allergic airway inflammation and airway remodeling in chronic asthma mice

Liyang Dong et al.

Summary: Hypoxic human umbilical cord MSC-derived EVs attenuated allergic airway inflammation and airway remodeling in chronic asthma mice, potentially offering new avenues for asthma treatment.

STEM CELL RESEARCH & THERAPY (2021)

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Article Plant Sciences

Quantitative proteomic profiling of targeted proteins associated with Loki Zupa Decoction Treatment in OVA-Induced asthmatic mice

Tulake Wuniqiemu et al.

Summary: The study confirmed the anti-inflammatory and anti-fibrotic role of LKZP decoction in airway, with ECM-receptor interaction being potentially involved. RMB 10 and COL6A6 were identified as potential targets of LKZP decoction in OVA-induced asthmatic mice.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Review Cell Biology