4.7 Article

Autophagy perturbation upon acute pyrethroid treatment impacts adipogenic commitment of mesenchymal stem cells

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

Autophagy: a molecular switch to regulate adipogenesis and lipolysis

Mouliganesh Sekar et al.

Summary: Obesity is a disease caused by an imbalance of adipose tissue function, and autophagy and adipogenesis are important mechanisms in its regulation. Autophagy regulates adipocyte differentiation and lipid metabolism, while adipogenesis and lipolysis are associated with the occurrence of obesity.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2022)

Article Environmental Sciences

Pyrethroids exposure induces obesity and cardiometabolic diseases in a sex-different manner

Lei Zuo et al.

Summary: This study found that exposure to pyrethroid pesticides is associated with an increased risk of obesity, especially in females. Obesity also partially mediates the associations between pyrethroid exposure and diabetes and cardiovascular disease.

CHEMOSPHERE (2022)

Article Multidisciplinary Sciences

Chaperone-mediated autophagy regulates differentiation

Susmita Kaushik et al.

Summary: This study reveals the crucial role of chaperone-mediated autophagy (CMA) in adipocyte differentiation, as it regulates adipogenesis at different steps through timely degradation of key regulatory signaling proteins and transcription factors.

SCIENCE ADVANCES (2022)

Article Biochemistry & Molecular Biology

KRAS Affects Adipogenic Differentiation by Regulating Autophagy and MAPK Activation in 3T3-L1 and C2C12 Cells

Wenjie Yu et al.

Summary: In this study, it was found that inhibition of KRAS in 3T3-L1 and C2C12 cells altered the expression of key proteins involved in cell proliferation, autophagy, and adipogenic differentiation, leading to reduced proliferation capacity, enhanced differentiation into mature adipocytes, and increased lipid accumulation. Additionally, KRAS inhibition decreased the activation levels of several signaling pathways during differentiation. These results demonstrate the unique regulatory effects of KRAS on cell processes related to adipogenesis and lipid accumulation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Multidisciplinary Sciences

The pesticide chlorpyrifos promotes obesity by inhibiting diet-induced thermogenesis in brown adipose tissue

Bo Wang et al.

Summary: The commonly used pesticide chlorpyrifos reduces energy expenditure by inhibiting diet-induced thermogenesis, contributing to obesity and insulin resistance. The suppression of uncoupling protein 1 (UCP1) and mitochondrial respiration in brown adipose tissue (BAT) by chlorpyrifos suggests its potential contribution to the obesity epidemic.

NATURE COMMUNICATIONS (2021)

Article Cell Biology

Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing FABP3

Zheng-Zhao Liu et al.

Summary: Senile osteoporosis (OP) is associated with decreased autophagic activity, with OPTN playing a crucial role in bone metabolism through selective autophagy. Reduced expression of OPTN during aging may lead to OP due to impaired degradation of FABP3 via selective autophagy, which impairs osteogenesis of MSCs and contributes to bone loss. Reactivating OPTN or inhibiting FABP3 could be a potential treatment strategy for senile OP.

AUTOPHAGY (2021)

Review Biochemistry & Molecular Biology

Roles of Autophagy in Oxidative Stress

Hyeong Rok Yun et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemistry & Molecular Biology

β-Cypermethrin promotes the adipogenesis of 3T3-L1 cells via inducing autophagy and shaping an adipogenesis-friendly microenvironment

Bingnan He et al.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2020)

Review Environmental Sciences

Deltamethrin toxicity: A review of oxidative stress and metabolism

Qirong Lu et al.

ENVIRONMENTAL RESEARCH (2019)

Article Pharmacology & Pharmacy

Cytotoxicity and Genotoxicity of Cypermethrin in Hepatocarcinoma Cells: A Dose- and Time-Dependent Study

Abdullah A. AlKahtane et al.

DOSE-RESPONSE (2018)

Article Environmental Sciences

Natural pyrethrins induce autophagy of HepG2 cells through the activation of AMPK/mTOR pathway

Yun Yang et al.

ENVIRONMENTAL POLLUTION (2018)

Article Food Science & Technology

Exposure to permethrin promotes high fat diet-induced weight gain and insulin resistance in male C57BL/6J mice

Xiao Xiao et al.

FOOD AND CHEMICAL TOXICOLOGY (2018)

Article Multidisciplinary Sciences

Carvacrol reduces adipogenic differentiation by modulating autophagy and ChREBP expression

Sonia Spalletta et al.

PLOS ONE (2018)

Article Food Science & Technology

Deltamethrin increases the fat accumulation in 3T3-L1 adipocytes and Caenorhabditis elegans

Peiyi Shen et al.

FOOD AND CHEMICAL TOXICOLOGY (2017)

Article Environmental Sciences

Cytotoxicity induced by cypermethrin in Human Neuroblastoma Cell Line SH-SY5Y

Grzegorz Raszewski et al.

ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE (2016)

Article Environmental Sciences

Distribution and Predictors of Pesticides in the Umbilical Cord Blood of Chinese Newborns

Monica K. Silver et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2016)

Review Environmental Sciences

Permethrin-induced oxidative stress and toxicity and metabolism. A review

Xu Wang et al.

ENVIRONMENTAL RESEARCH (2016)

Article Biochemistry & Molecular Biology

Cypermethrin Induces Macrophages Death through Cell Cycle Arrest and Oxidative Stress-Mediated JNK/ERK Signaling Regulated Apoptosis

Fang Huang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Article Multidisciplinary Sciences

Autophagy maintains stemness by preventing senescence

Laura Garcia-Prat et al.

NATURE (2016)

Review Cell Biology

Effects of Oxidative Stress on Mesenchymal Stem Cell Biology

Ryan A. Denu et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

Review Cell & Tissue Engineering

The Role of Autophagy in the Maintenance of Stemness and Differentiation of Mesenchymal Stem Cells

Francesca Vittoria Sbrana et al.

STEM CELL REVIEWS AND REPORTS (2016)

Review Cell & Tissue Engineering

The Role of Autophagy in the Maintenance of Stemness and Differentiation of Mesenchymal Stem Cells

Francesca Vittoria Sbrana et al.

STEM CELL REVIEWS AND REPORTS (2016)

Review Cell & Tissue Engineering

The Role of Reactive Oxygen Species in Mesenchymal Stem Cell Adipogenic and Osteogenic Differentiation: A Review

Fatemeh Atashi et al.

STEM CELLS AND DEVELOPMENT (2015)

Article Environmental Sciences

Evaluation of pyrethroid exposures in pregnant women from 10 Caribbean countries

Eric Dewailly et al.

ENVIRONMENT INTERNATIONAL (2014)

Article Biochemistry & Molecular Biology

Permethrin Alters Adipogenesis in 3T3-L1 Adipocytes and Causes Insulin Resistance in C2C12 Myotubes

Jonggun Kim et al.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2014)

Article Food Science & Technology

Activation of autophagy and AMPK by gamma-tocotrienol suppresses the adipogenesis in human adipose derived stem cells

Lu Zhao et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2014)

Article Cell & Tissue Engineering

Human mesenchymal stem cells/multipotent stromal cells consume accumulated autophagosomes early in differentiation

Austin Nuschke et al.

STEM CELL RESEARCH & THERAPY (2014)

Article Endocrinology & Metabolism

Autophagy is involved in adipogenic differentiation by repressesing proteasome-dependent PPARγ2 degradation

Chongben Zhang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2013)

Article Endocrinology & Metabolism

Defective regulation of adipose tissue autophagy in obesity

C. E. Nunez et al.

INTERNATIONAL JOURNAL OF OBESITY (2013)

Article Endocrinology & Metabolism

Altered Autophagy in Human Adipose Tissues in Obesity

Julia Kovsan et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2011)

Review Cell Biology

Adipocyte differentiation from the inside out

Evan D. Rosen et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)

Article Cell Biology

C/EBP alpha induces adipogenesis through PPAR gamma: a unified pathway

ED Rosen et al.

GENES & DEVELOPMENT (2002)