Highlighting functions of apoptosis and circular RNAs in colorectal cancer

Colorectal cancer (CRC) is known as one of the global problems that endangers the lives of thousands of people every year. Various treatments have been used to deal with this disease, but in some cases, they are not effective. Circular RNAs, as a novel class of noncoding RNAs, have different expression levels and various functions in cancer cells, such as gene regulation through microRNA sponging. They play an important role in various cellular processes, including differentiation, proliferation, invasion, and apoptosis. Changes in the process of apoptosis are closely related to the progression or inhibition of various malignancies. Induction of apoptosis in cancer cells is a promising target for tumor therapy. In this study, circRNAs were investigated as being central to the in-duction or inhibition of apoptosis in CRC. It is hoped that through targeted changes in the function of these biomolecules, better outcomes will be achieved in cancer treatment. Perhaps better outcomes for cancer treat-ment can be achieved by using new methods and modifying the expression of these nucleic acids. However, using this method may come with challenges and limitations.

Automated summary

Colorectal cancer (CRC) is a global problem that poses a threat to thousands of lives annually. Circular RNAs, a class of noncoding RNAs, have various functions in cancer cells and play a critical role in cellular processes like differentiation, proliferation, invasion, and apoptosis. This study investigates the involvement of circRNAs in the induction or inhibition of apoptosis in CRC, aiming to achieve better outcomes in cancer treatment by targeting these biomolecules and modifying their expression. However, challenges and limitations may arise when using this approach.