4.5 Article

TRIM21 promotes tumor progression and cancer stemness in cervical squamous cell carcinoma

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Effects of Fractionated Radiation Exposure on Vimentin Expression in Cervical Cancers: Analysis of Association with Cancer Stem Cell Response and Short-Term Prognosis

Irina Zamulaeva et al.

Summary: This study evaluated the effects of fractionated radiation exposure on vimentin expression and its association with CSC radiation response and short-term prognosis of CC patients. The results showed correlations between vimentin expression and changes in CSC numbers, as well as unfavorable clinical outcome after treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Review Oncology

Harnessing cancer stem cell-derived exosomes to improve cancer therapy

Jianqiang Yang et al.

Summary: Cancer stem cells (CSCs) are important seeds for tumor development and progression. Exosomes derived from CSCs play a significant role in various aspects of cancer. Understanding the characteristics and function of CSC-derived exosomes can potentially lead to the development of new clinical tools and therapies for cancer treatment.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2023)

Article Multidisciplinary Sciences

TRIM21 inhibits irradiation-induced mitochondrial DNA release and impairs antitumour immunity in nasopharyngeal carcinoma tumour models

Jun-Yan Li et al.

Summary: This study shows that the expression of TRIM21 in tumors is inversely associated with the response to radiation and CD8(+) T cell-mediated antitumour immunity in nasopharyngeal carcinoma (NPC). TRIM21 inhibits the release of mitochondrial DNA and interferon responses following radiation exposure. High TRIM21 expression is associated with poor prognosis and early tumor relapse in patients with NPC.

NATURE COMMUNICATIONS (2023)

Article Biochemistry & Molecular Biology

TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization

Wenqing Gao et al.

Summary: The tripartite motif protein TRIM21 has been identified as a positive regulator of GSDMD-dependent pyroptosis, maintaining stable expression of GSDMD and inducing GSDMD-N aggregation during pyroptosis. Cells deficient in TRIM21 showed reduced cell death in response to inflammasome activation, and genetic ablation of TRIM21 in mice provided protection from inflammation and colitis. This suggests that TRIM21 plays an essential role in GSDMD-mediated pyroptosis and may be a potential target for treating inflammation-associated diseases.

CELL DEATH AND DIFFERENTIATION (2022)

Article Biochemistry & Molecular Biology

CD44+and CD133+Non-Small Cell Lung Cancer Cells Exhibit DNA Damage Response Pathways and Dormant Polyploid Giant Cancer Cell Enrichment Relating to Their p53 Status

Margarita Pustovalova et al.

Summary: Cancer stem cells play a critical role in non-small cell lung cancer, and differences in DNA-damage signaling and dormant features have been observed between different subpopulations, which have important implications for treatment strategies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Biotechnology & Applied Microbiology

TRIM21 deficiency promotes cell proliferation and tumorigenesis via regulating p21 expression in ovarian cancer

Jieyun Sun et al.

Summary: TRIM21 expression is decreased in ovarian cancer patients and is associated with shorter survival. It inhibits cancer progression by suppressing cell migration, invasion, and proliferation. Therefore, TRIM21 may serve as a promising biomarker and therapeutic target for ovarian cancer.

BIOENGINEERED (2022)

Article Oncology

ARPC1B promotes mesenchymal phenotype maintenance and radiotherapy resistance by blocking TRIM21-mediated degradation of IFI16 and HuR in glioma stem cells

Zijie Gao et al.

Summary: ARPC1B is upregulated in MES-GBM/GSCs and correlated with poor prognosis. Knockdown of ARPC1B reduces radiotherapy resistance in GSCs. ARPC1B interacts with IFI16 and HuR to maintain protein stability and activates NF-kappa B and STAT3 pathways, promoting MES phenotype maintenance and radiotherapy resistance. Furthermore, AZD6738, identified based on ARPC1B expression, exhibits excellent anti-GSC activity in combination with radiotherapy.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

Article Immunology

TRIM21 Regulates Virus-Induced Cell Pyroptosis through Polyubiquitination of ISG12a

Mengmeng Guo et al.

Summary: This study reveals a new mechanism of TRIM21 and ISG12a in regulating virus-induced cell pyroptosis.

JOURNAL OF IMMUNOLOGY (2022)

Review Pharmacology & Pharmacy

TRIM21-A potential novel therapeutic target in cancer

Munther Alomari

Summary: TRIM21 is involved in innate immunity, systemic lupus erythematosus, Sjogren's syndrome, and cancer proliferation. It is shown to affect major cancer-promoting proteins and signaling pathways in the presence of various carcinogenesis effectors. TRIM21 may enhance cancer proliferation or induce the degradation of cancer-triggering proteins, highlighting its potential as a novel cancer therapeutic target.

PHARMACOLOGICAL RESEARCH (2021)

Article Biochemistry & Molecular Biology

HPV E7 inhibits cell pyroptosis by promoting TRIM21-mediated degradation and ubiquitination of the IFI16 inflammasome

Yinjing Song et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2020)

Review Oncology

Cancer stem cells (CSCs), cervical CSCs and targeted therapies

Ruixia Huang et al.

ONCOTARGET (2017)

Review Immunology

TRIM21: a cytosolic Fc receptor with broad antibody isotype specificity

Stian Foss et al.

IMMUNOLOGICAL REVIEWS (2015)

Editorial Material Multidisciplinary Sciences

THE CANCER STEM CELL GAMBLE

Jocelyn Kaiser

SCIENCE (2015)

Article Obstetrics & Gynecology

Possible association between stem-like hallmark and radioresistance in human cervical carcinoma cells

Shoko Kumazawa et al.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH (2014)

Review Oncology

Cancer stem cell definitions and terminology: the devil is in the details

Peter Valent et al.

NATURE REVIEWS CANCER (2012)

Review Oncology

Cancer Stem Cell Niche: The Place to Be

Tijana Borovski et al.

CANCER RESEARCH (2011)

Article Biochemistry & Molecular Biology

The epithelial-mesenchymal transition generates cells with properties of stem cells

Sendurai A. Mani et al.