☆ 4.5 Review

Unveiling the connection: Long-chain non-coding RNAs and critical signaling pathways in breast cancer

PATHOLOGY RESEARCH AND PRACTICE (2023)

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Signature of miR-21 and MEG-2 and their correlation with TGF-beta signaling in breast cancer

E. M. Desouky et al.

Summary: This study aimed to evaluate the reliability of miR-21 and MEG-2 expression levels in serum as diagnostic biomarkers for breast cancer and investigate their correlations with TGF-beta expression. The results showed that miR-21 and TGF-beta were upregulated in breast cancer patients, and elevated miR-21/TGF-beta levels were consistent with cancer stage. On the other hand, MEG-2 expression was downregulated in breast cancer patients, with gradual decrease consistent with cancer stage. A negative relationship between MEG-2 and miR-21/TGF-beta differential expression was also observed. This study suggests that miR-21 and MEG-2 could be potential diagnostic biomarkers for breast cancer, and highlights the importance of TGF-beta as a therapeutic target.

HUMAN & EXPERIMENTAL TOXICOLOGY (2023)

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Review Oncology

Enhancement of immune surveillance in breast cancer by targeting hypoxic tumor endothelium: Can it be an immunological switch point?

Juvin Ann Thomas et al.

Summary: Breast cancer is the second leading cause of cancer-related deaths in women. The presence of a hypoxic microenvironment in tumors leads to immune suppression and the recruitment of immune cells that promote tumor growth. Immunotherapy and vascular normalisation may improve tumor access and immune response in the hypoxic tumor microenvironment. This article discusses the potential impact of immune-herbal therapeutic and immune-nutraceuticals approaches in attenuating breast cancer growth and preventing metastasis.

FRONTIERS IN ONCOLOGY (2023)

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Interplay between LncRNAs and microRNAs in Breast Cancer

Heidi Schwarzenbach et al.

Summary: Although lncRNAs are precursors of miRNAs, they also act as ceRNAs and their interaction with miRNAs may modulate miRNA action. To understand their contribution to tumor resistance, both the function of miRNAs and the impact of lncRNAs on miRNAs need to be considered. This study focuses on the interplay between lncRNAs and miRNAs in the post-transcriptional regulatory network and their impact on breast cancer treatment drugs. Considering this interplay may improve the search for new drugs to overcome chemoresistance.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Review Biochemistry & Molecular Biology

Drugging the PI3K/AKT/mTOR Pathway in ER plus Breast Cancer

Carla L. Alves et al.

Summary: The PI3K/AKT/mTOR pathway plays a crucial role in estrogen receptor-positive breast cancer tumorigenesis and drug resistance, making it a highly attractive therapeutic target. Several inhibitors targeting this pathway are currently under clinical development. The recent approval of the PIK3CA isoform-specific inhibitor alpelisib and the pan-AKT inhibitor capivasertib, in combination with fulvestrant, has provided new treatment options for advanced estrogen receptor-positive breast cancer patients. However, the clinical development of multiple inhibitors and incorporating CDK4/6 inhibitors into the standard treatment has complicated the personalization of therapy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Biochemistry & Molecular Biology

SNHG3 could promote prostate cancer progression through reducing methionine dependence of PCa cells

Xiaotian Wang et al.

Summary: In recent years, the morbidity and mortality of prostate cancer have increased dramatically, while the understanding of its onset and progression remains limited. In this study, it was discovered that SNHG3 acts as a molecular sponge and stimulates proliferation, migration, and invasion of prostate cancer cells by targeting SLC7A11. It also inhibits methionine dependence and apoptosis and affects the cell cycle. These findings provide new insights into the molecular mechanism of SNHG3 in regulating prostate cancer progression.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2022)

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Review Biochemistry & Molecular Biology

A review on epidermal growth factor receptor's role in breast and non-small cell lung cancer

Vetriselvan Subramaniyan et al.

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CHEMICO-BIOLOGICAL INTERACTIONS (2022)

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Article Agriculture, Dairy & Animal Science

Identify known and novel candidate genes associated with backfat thickness in Duroc pigs by large-scale genome-wide association analysis

Rongrong Ding et al.

Summary: Backfat thickness (BFT) is an economically important trait in the pig industry, and genetic markers and candidate genes related to BFT were identified through genotyping and genome-wide association analysis in two Duroc populations. Most candidate genes can be directly used for genetic improvement through molecular markers. New insights gained from this study will contribute to genetic studies aiming to increase carcass lean meat percentage in pigs.

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Article Medical Laboratory Technology

LncRNA UCA1, miR-26a, and miR-195 in coronary heart disease patients: Correlation with stenosis degree, cholesterol levels, inflammatory cytokines, and cell adhesion molecules

Jie Li et al.

Summary: The study revealed that lnc-UCA1 was upregulated while miR-26a and miR-195 were downregulated in patients with CHD, and there were negative correlations between lnc-UCA1 and miR-26a/miR-195. Additionally, lnc-UCA1 was positively associated with disease severity and inflammatory markers, while miR-26a showed negative correlations with certain inflammatory markers.

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Article Medical Laboratory Technology

Expression changes of serum LINC00941 and LINC00514 in HBV infection-related liver diseases and their potential application values

Juanjuan Chen et al.

Summary: This study demonstrated that LINC00941 and LINC00514 were elevated in serum of HBV infection-related liver diseases, and they might serve as independent markers for the detection of liver diseases.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2022)

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Article Oncology

MiR-423-5p prevents MALAT1-mediated proliferation and metastasis in prostate cancer

Carmela Ferri et al.

Summary: This study found that MALAT1 expression is associated with high Gleason grade, metastasis occurrence, and reduced survival in PCa patients. The study also revealed a direct interaction between miR-423-5p and MALAT1, which inhibits MALAT1's activity and suppresses cell proliferation, migration, and invasion in PCa.

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Article Cell Biology

lncRNA IGF2-AS Regulates Nucleotide Metabolism by Mediating HMGA1 to Promote Pyroptosis of Endothelial Progenitor Cells in Sepsis Patients

Guibin Liang et al.

Summary: This study investigated the effects of lncRNA IGF2-AS and HMGA1 on the pyroptosis of endothelial progenitor cells (EPCs) in sepsis patients and the underlying mechanisms. The findings showed that lncRNA IGF2-AS regulated nucleotide metabolism by mediating HMGA1 and promoted pyroptosis of EPCs. Additionally, it was found that MSC-derived exosomes transferred lncRNA IGF2-AS to EPCs, leading to increased pyroptosis. These results provide important clues for identifying new therapeutic targets for sepsis.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Article Cell Biology

Hypoxia-induced lncRNA RBM5-AS1 promotes tumorigenesis via activating Wnt/beta-catenin signaling in breast cancer

Xinping Li et al.

Summary: RBM5-AS1 plays a crucial role in breast cancer initiation and progression by regulating the Wnt/β-catenin signaling pathway.

CELL DEATH & DISEASE (2022)

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Article Reproductive Biology

Serum CCAT2 as a biomarker for adjuvant diagnosis and prognostic prediction of cervical cancer

Xiaoli Cao et al.

Summary: This study suggests that lncRNA CCAT2 may have clinical value in complementary diagnosis and monitoring of progression and prognosis in cervical cancer patients. Combined detection of CCAT2, CA125, and SCC can greatly improve the diagnostic efficiency of primary cervical cancer.

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HOTAIR-Loaded Mesenchymal Stem/Stromal Cell Extracellular Vesicles Enhance Angiogenesis and Wound Healing

Louis J. Born et al.

Summary: This study explores the potential of using extracellular vesicles (EVs) for delivery of HOTAIR as a strategy to promote healing of chronic wounds.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Biotechnology & Applied Microbiology

Identification of novel key regulatory lncRNAs in gastric adenocarcinoma

Houri Razavi et al.

Summary: This study constructed a STAD lncRNA-mRNA network and found that the high degree nodes were associated with overall survival and had been confirmed in other cancers. Through mapping lncRNAs to GO terms and cancer hallmarks, the potential associations between lncRNAs and hallmarks were predicted and confirmed through literature review. Furthermore, a lncRNA signature was developed to classify STAD patients into high and low-risk subgroups with significantly different survival outcomes.

BMC GENOMICS (2022)

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Article Biotechnology & Applied Microbiology

LncRNA SNHG5 promotes the proliferation and cancer stem cell-like properties of HCC by regulating UPF1 and Wnt-signaling pathway

Yarui Li et al.

Summary: This study reveals the role of lncRNA SNHG5 in promoting cell proliferation and cancer stem cell-like properties in hepatocellular carcinoma (HCC). Knockdown of SNHG5 inhibits HCC cell proliferation and CSC-like properties, while over-expression of SNHG5 promotes cell growth. Mechanistically, SNHG5 regulates HCC proliferation and CSC-like properties by binding UPF1 and activating the Wnt/β-catenin pathway.

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Sodium alginate based drug delivery in management of breast cancer

Mohammad Arshad Javed Shaikh et al.

Summary: Breast cancer is a common disease among women worldwide, and sodium alginate as a drug carrier shows potential for treating breast cancer.

CARBOHYDRATE POLYMERS (2022)

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Review Biochemistry & Molecular Biology

Dormancy in Breast Cancer, the Role of Autophagy, lncRNAs, miRNAs and Exosomes

Leila Jahangiri et al.

Summary: Breast cancer is the most common cancer in women, and its targeted treatment depends on the expression of growth factors and hormone receptors by cancer cells. However, approximately 30% of patients may experience relapse due to residual disseminated tumor cells that can either colonize a secondary site or enter a dormant state. Understanding the microenvironmental cues, metabolic and molecular properties, as well as the role of autophagy, lncRNAs, miRNAs, and exosomes, could improve the treatment of breast cancer and enhance patient prognosis and survival.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Oncology

LncCCAT1 interaction protein PKM2 upregulates SREBP2 phosphorylation to promote osteosarcoma tumorigenesis by enhancing the Warburg effect and lipogenesis

Feifei Pu et al.

Summary: The study reveals that pyruvate kinase M2 (PKM2) binds to long noncoding RNAs (lncRNAs) associated with cancer pathogenesis and development, promoting the growth and development of osteosarcoma (OS). This finding extends the understanding of PKM2's biological functions in tumorigenesis and highlights its potential as a therapeutic target for OS.

INTERNATIONAL JOURNAL OF ONCOLOGY (2022)

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Article Biochemistry & Molecular Biology

CTCF-Induced lncRNA C5orf66-AS1 Facilitates the Progression of Triple-Negative Breast Cancer via Sponging miR-149-5p to Up-Regulate CTCF and CTNNB1 to Activate Wnt/β-Catenin Pathway

Shuangjiu Zhu et al.

Summary: This study revealed the functional role of lncRNA C5orf66-AS1 in TNBC and demonstrated its importance as an oncogene in promoting TNBC malignancy. Through regulation of miR-149-5p and CTNNB1 expression, C5orf66-AS1 activated the Wnt/beta-catenin signaling pathway, thereby promoting TNBC cell proliferation, migration, and invasion while inhibiting apoptosis.

MOLECULAR AND CELLULAR BIOLOGY (2022)

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Review Biochemistry & Molecular Biology

Noncoding RNAs related to the hedgehog pathway in cancer: clinical implications and future perspectives

Jia Song et al.

Summary: This review examines the roles of the Hh pathway and ncRNAs in cancer development and treatment, as well as their crosstalk. ncRNAs related to the Hh pathway can serve as biomarkers for cancer therapy and targets for further research.

MOLECULAR CANCER (2022)

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Article Biochemistry & Molecular Biology

Interaction of lncRNA MIR100HG with hnRNPA2B1 facilitates m6A-dependent stabilization of TCF7L2 mRNA and colorectal cancer progression

Hao Liu et al.

Summary: The study reveals that MIR100HG serves as a positive regulator of EMT in CRC, sustaining cetuximab resistance and promoting invasion and metastasis. It interacts with hnRNPA2B1 to control Wnt signaling transcriptional activity via regulation of TCF7L2 mRNA stability, forming a feedback loop that may contribute to cetuximab resistance and metastasis in CRC.

MOLECULAR CANCER (2022)

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Article Medicine, General & Internal

Long non-coding RNA HOTAIR induces the PI3K/AKT/mTOR signaling pathway in breast cancer cells

Mona Sadeghalvad et al.

Summary: The study identified that silencing long non-coding RNA HOX antisense intergenic RNA in breast cancer cells can downregulate the expression of PI3K, AKT, and mTOR, leading to reduced proliferation of breast cancer cells.

REVISTA DA ASSOCIACAO MEDICA BRASILEIRA (2022)

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Article Virology

EGR1 Upregulation during Encephalitic Viral Infections Contributes to Inflammation and Cell Death

Caitlin W. Lehman et al.

Summary: EGR1 is a transcription factor associated with human astrocytoma cell infection by Venezuelan equine encephalitis virus (VEEV) and can regulate the expression of multiple inflammatory genes. EGR1 is upregulated in various alphavirus infections and plays an important role in cell death and inflammatory response following infection.

VIRUSES-BASEL (2022)

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Article Cell Biology

M1 macrophage-derived exosomes and their key molecule lncRNA HOTTIP suppress head and neck squamous cell carcinoma progression by upregulating the TLR5/NF-κB pathway

Huaili Jiang et al.

Summary: This study revealed that M1-derived exosomes containing HOTTIP activate the TLR5/NF-kappa B signaling pathway by competitively sponging miR-19a-3p and miR-19b-3p, thereby suppressing the progression of head and neck squamous cell carcinoma (HNSCC). Additionally, M1-derived exosomes and HOTTIP induce the polarization of circulating monocytes towards an M1 phenotype, providing new insights into HNSCC immunotherapy.

CELL DEATH & DISEASE (2022)

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Article Environmental Sciences

Identification of Candidate lncRNA and Pseudogene Biomarkers Associated with Carbon-Nanotube-Induced Malignant Transformation of Lung Cells and Prediction of Potential Preventive Drugs

Guangtao Chang et al.

Summary: This study links carbon nanotube (CNT) exposure with lung cancer and identifies crucial long non-coding RNAs (lncRNAs) and pseudogenes. It also predicts potential preventive drugs and suggests lncRNAs and pseudogenes as diagnostic biomarkers and drug targets for CNT-induced lung cancer.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2022)

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Article Biotechnology & Applied Microbiology

HOTAIR mediates cisplatin resistance in nasopharyngeal carcinoma by regulating miR-106a-5p/SOX4 axis

Wei Cao et al.

Summary: This study investigated the role of HOTAIR in drug resistance in nasopharyngeal carcinoma (NPC). It was found that upregulated expression of HOTAIR in NPC tissues and cells was associated with cisplatin resistance. Knockdown of HOTAIR increased cell sensitivity to cisplatin and reduced cell viability, chemoresistance-related protein expression, migration, invasion, and induced cell apoptosis. In addition, downregulation of miR-106a-5p expression and upregulation of SOX4 expression were observed in cisplatin-resistant NPC tissues and cells. HOTAIR regulated the miR-106a-5p/SOX4 axis to enhance drug resistance in NPC cells.

BIOENGINEERED (2022)

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Article Toxicology

Anticancer Phytochemical-Based Nanoformulations: Therapeutic Intervention in Cancer Cell Lines

Debjyoti Talukdar et al.

JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY (2022)

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Exploring the Mechanical Perspective of a New Anti-Tumor Agent: Melatonin

Suman Rohilla et al.

JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY (2022)

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Review Biotechnology & Applied Microbiology

Intraductal delivery of nanocarriers for ductal carcinoma in situ treatment: a strategy to enhance localized delivery

Manisha Pandey et al.

Summary: Ductal carcinoma in situ (DCIS) is the most common noninvasive malignant breast disease, which may contribute to invasive breast cancer. Nanocarriers incorporated in the drug-delivery system offer advantages over conventional therapy, promoting targeted treatment and minimizing adverse effects. Direct intraductal delivery allows drug accumulation at the site of action, and this approach has also been applied in managing other diseases.

NANOMEDICINE (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Long Noncoding RNA CASC2 Facilitated Wound Healing through miRNA-155/HIF-1α in Diabetic Foot Ulcers

Minjie He et al.

Summary: In this study, the role of lncRNA CASC2/miR-155/HIF-1 alpha in the wound healing of diabetic foot ulcers (DFU) was investigated. The overexpression of lncRNA CASC2 promoted fibroblasts migration and proliferation, and inhibited apoptosis, benefiting the healing of DFU wounds. Additionally, lncRNA CASC2 directly targeted miR-155 and miR-155's function was associated with HIF-1 alpha.

CONTRAST MEDIA & MOLECULAR IMAGING (2022)

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Article Multidisciplinary Sciences

LncRNA CCAT2, involving miR-34a/TGF-β1/Smad4 signaling, regulate hepatic stellate cells proliferation

Haibing Gao et al.

Summary: This study found that lncRNA CCAT2 may regulate the TGF-beta 1 pathway in hepatic stellate cells (HSCs) by modulating miR-34a-5p, thus alleviating liver fibrosis.

SCIENTIFIC REPORTS (2022)

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Review Biochemistry & Molecular Biology

Immunomodulatory Properties of PI3K/AKT/mTOR and MAPK/MEK/ERK Inhibition Augment Response to Immune Checkpoint Blockade in Melanoma and Triple-Negative Breast Cancer

Zhizhu Zhang et al.

Summary: Hyperactivation of PI3K/AKT/mTOR and MAPK/MEK/ERK signaling pathways is common in various cancers, and targeting these pathways may enhance the response to immune checkpoint inhibitors (ICIs) as a strategy to overcome resistance.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Oncology

Long non-coding RNA 01614 hyperactivates WNT/beta-catenin signaling to promote pancreatic cancer progression by suppressing GSK-3 beta

Long-Jiang Chen et al.

Summary: The study identified a lncRNA called linc01614 which is upregulated in pancreatic cancer tissues and cell lines. Knockdown of linc01614 inhibits cell proliferation, migration, and invasion, and it stabilizes beta-catenin protein to activate the WNT/beta-catenin signaling pathway. This study suggests that linc01614 may function as an oncogene and could be a potential therapeutic target for pancreatic cancer.

INTERNATIONAL JOURNAL OF ONCOLOGY (2022)

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Article Biotechnology & Applied Microbiology

Abnormally Expressed lncRNAs as Potential Biomarkers for Gastric Cancer Risk: A Diagnostic Meta-Bioinformatics Analysis

Ying-ying Dong et al.

Summary: This study conducted a diagnostic meta-bioinformatics analysis to explore the association between long non-coding RNA (lncRNA) expression and gastric cancer (GC) risk. The results indicated that abnormally expressed lncRNAs, especially circulating lncRNAs, might serve as potential diagnostic biomarkers for GC risk. Additionally, a novel combined model of lncRNAs showed promising performance in GC diagnosis.

BIOMED RESEARCH INTERNATIONAL (2022)

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Article Biochemistry & Molecular Biology

LncRNA EPR-induced METTL7A1 modulates target gene translation

Paola Briata et al.

Summary: EPR is an lncRNA that regulates cell proliferation in mammary gland cells by controlling gene transcription. Mettl7a1 is identified as a direct target of EPR and is involved in inhibiting TGF-beta signaling. Downregulation of METTL7A1 in breast cancers is associated with tumorigenic potential, but its re-expression can attenuate tumor cell transformation. The cytoplasmic localization of METTL7A1 suggests its involvement in mRNA translation.

NUCLEIC ACIDS RESEARCH (2022)

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Article Oncology

N6-methyladenosine-modified lncRNA ARHGAP5-AS1 stabilises CSDE1 and coordinates oncogenic RNA regulons in hepatocellular carcinoma

Jiandong Liu et al.

Summary: This study identifies the biologic functions of m(6)A-modified lncRNA ARHGAP5-AS1 in HCC and reveals its promotion of hepatocarcinogenesis through controlling CSDE1-mediated oncogenic RNA regulons.

CLINICAL AND TRANSLATIONAL MEDICINE (2022)

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Article Multidisciplinary Sciences

The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors

Jasmin Bartl et al.

Summary: Long non-coding RNA (lncRNA) HHIP-AS1 stabilizes the mRNA of dynein complex 1, thereby promoting the pro-mitotic effects of SHH-driven tumors.

NATURE COMMUNICATIONS (2022)

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The Role of TAMs in Tumor Microenvironment and New Research Progress

Yawei Feng et al.

Summary: This paper summarizes the role of tumor-associated macrophages in the formation of tumor microenvironment and discusses the feasibility of TAMs-targeted therapy.

STEM CELLS INTERNATIONAL (2022)

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Article Immunology

LncRNA profiles from Notch signaling: Implications for clinical management and tumor microenvironment of colorectal cancer

Qin Dang et al.

Summary: This study provides a framework for screening Notch-derived lncRNAs in colorectal cancer (CRC) and identifies clinically significant lncRNAs associated with prognosis. The NLncS model, consisting of six lncRNAs, is shown to be an independent risk factor and a robust biomarker for assessing the prognosis of CRC patients. Patients with high NLncS risk scores exhibit upregulation of immune pathways, strong immunogenicity, CD8+ T-cell infiltration, and potentially higher response rates to CTLA4 blockers, making them suitable candidates for immunotherapy. Additionally, the study identifies dasatinib as a potential agent for high-risk CRC patients.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Medicine, Research & Experimental

HOTAIR in solid tumors: Emerging mechanisms and clinical strategies

Xiangchen An et al.

Summary: This review summarizes the role of HOTAIR in solid tumors and its clinical applicability as a biomarker for disease diagnosis, prognosis, and targeted therapy.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Review Medicine, Research & Experimental

Role of hedgehog signaling related non-coding RNAs in developmental and pathological conditions

Zanyar HajiEsmailPoor et al.

Summary: This review provides a comprehensive analysis of the link between non-coding RNAs and Hh signaling pathways in human diseases and development, emphasizing their therapeutic, prognostic, and diagnostic significance.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Review Biochemistry & Molecular Biology

An overview of epithelial growth factor receptor (EGFR) inhibitors in cancer therapy

Khalid Saad Alharbi et al.

Summary: This review provides an overview of the crucial role of EGFR in cancer, the discovery of related oncogenic pathways and resistance mechanisms, and clinical studies targeting EGFR in various tumors.

CHEMICO-BIOLOGICAL INTERACTIONS (2022)

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Article Biochemistry & Molecular Biology

Long noncoding RNA HOTAIR regulates the stemness of breast cancer cells via activation of the NF-KB signaling pathway

Jiajia Wang et al.

Summary: This study found that HOTAIR plays a role in promoting self-renewal and tumor propagation of breast cancer stem cells. HOTAIR recruits the PRC2 protein complex to inhibit the expression of IKBa, leading to activation of the NF-KB signaling pathway and promoting the expression of c-Myc and Cyclin D1. Clinical data analysis also showed that breast cancer patients with high HOTAIR expression have a lower survival rate.

JOURNAL OF BIOLOGICAL CHEMISTRY (2022)

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Review Biochemistry & Molecular Biology

Role of Medicinal plant-derived Nutraceuticals as a potential target for the treatment of breast cancer

Khalid Saad Alharbi et al.

Summary: Breast cancer is a challenging cancer to treat, but nutraceuticals can be a beneficial supplementary therapy in reducing disease severity, limiting malignant cell growth, and modifying cancer-related mechanisms.

JOURNAL OF FOOD BIOCHEMISTRY (2022)

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Article Cell Biology

Breast Cancer Cells Reprogram the Oncogenic lncRNAs/mRNAs Coexpression Networks in Three-Dimensional Microenvironment

Stephanie Nunez-Olvera et al.

Summary: This study investigates the expression and potential roles of lncRNAs in 3D cultures of breast cancer cells, and identifies correlations similar to those found in breast cancer patients. The findings suggest that co-expressed lncRNAs/mRNAs pairs play important biological roles in breast cancer and have potential clinical applications.

CELLS (2022)

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Article Oncology

LncRNA DUXAP8 induces breast cancer radioresistance by modulating the PI3K/AKT/mTOR pathway and the EZH2-E-cadherin/RHOB pathway

Changjiang Lei et al.

Summary: This study found that DUXAP8 plays a critical role in radiation resistance in breast cancer. High expression of DUXAP8 is associated with poor prognosis. DUXAP8 enhances radioresistance of breast cancer cells by modulating the PI3K/AKT/mTOR pathway and interacting with EZH2.

CANCER BIOLOGY & THERAPY (2022)

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Article Cardiac & Cardiovascular Systems

Knockdown of lncRNA XIST Ameliorates IL-1β-Induced Apoptosis of HUVECs and Change of Tissue Factor Level via miR-103a-3p/HMGB1 Axis in Deep Venous Thrombosis by Regulating the ROS/NF-κB Signaling Pathway

Guangxin Cao et al.

Summary: This study reveals the mechanism by which lncRNA XIST induces deep vein thrombosis through intracellular signaling pathways, leading to HUVEC apoptosis via activation of the ROS/NF-κB pathway. This finding suggests that lncRNA XIST may be a potential therapeutic target for DVT.

CARDIOVASCULAR THERAPEUTICS (2022)

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Article Medicine, General & Internal

Baicalin suppresses the migration and invasion of breast cancer cells via the TGF-β/lncRNA-MALAT1/miR-200c signaling pathway

Jiafeng Li et al.

Summary: This study validates the suppression of breast cancer cell migration and invasion by baicalin through regulating the TGF-beta/lncRNA-MALAT1/miR-200c pathway.

MEDICINE (2022)

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Review Medicine, General & Internal

Crucial Roles of LncRNAs-Mediated Autophagy in Breast Cancer

Xinwei Han et al.

Summary: Breast cancer is a global public health issue, and both LncRNA and autophagy play important roles in its occurrence and development. Studies have shown that lncRNA-mediated autophagy is involved in regulating drug resistance sensitivity in different types of breast cancer. Abnormal expression of LncRNA may lead to dysregulation of autophagy and increase tumor incidence and drug resistance.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2022)

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Article Cell Biology

LncRNA SNHG3 promotes gastric cancer cell proliferation and metastasis by regulating the miR-139-5p/MYB axis

Yan Xie et al.

Aging-US (2021)

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Article Orthopedics

LncRNA HOTTIP leads to osteoarthritis progression via regulating miR-663a/Fyn-related kinase axis

Xianwei He et al.

Summary: HOTTIP is involved in the proliferation and apoptosis of OA chondrocytes via the miR-663a/FRK axis, indicating a potential target for the treatment of OA.

BMC MUSCULOSKELETAL DISORDERS (2021)

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Role of miRNA and lncRNAs in organ fibrosis and aging

Soudeh Ghafouri-Fard et al.

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BIOMEDICINE & PHARMACOTHERAPY (2021)

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Review Biochemistry & Molecular Biology

PI3K/AKT/mTOR Signaling Pathway in Breast Cancer: From Molecular Landscape to Clinical Aspects

Daniela Miricescu et al.

Summary: Breast cancer is a complex disease with various factors contributing to its pathogenesis. Current research is focused on the PI3K/AKT/mTOR signaling pathway and related cancer mutations. Clinical trials are also evaluating the efficacy of inhibitors targeting these signaling pathways in breast cancer treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Cell Biology

A novel autophagy-related lncRNA prognostic risk model for breast cancer

Xiaoying Li et al.

Summary: In this study, autophagy-related lncRNAs were identified in breast cancer and a prognostic risk model consisting of 11 autophagy-related lncRNAs was developed. The risk model was validated as an independent prognostic factor for breast cancer patients, and the low-risk and high-risk groups exhibited different autophagy and oncogenic statuses.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Pathology

Long non-coding RNA DUXAP8 elevates RCN2 expression and facilitates cell malignant behaviors and angiogenesis in cervical cancer via sponging miR-1297

Jihui Gu et al.

Summary: This study demonstrated that DUXAP8 promotes malignant behaviors in cervical cancer cells via regulating the miR-1297/RCN2 axis.

DIAGNOSTIC PATHOLOGY (2021)

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Article Oncology

GAS5 regulates diabetic cardiomyopathy via miR-221-3p/p27 axis-associated autophagy

Dezhi Chen et al.

Summary: The study found that the long non-coding RNA GAS5 promotes cardiomyocyte autophagy via the miR-221-3p/p27 axis to alleviate cardiac damage in diabetic cardiomyopathy.

MOLECULAR MEDICINE REPORTS (2021)

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Article Oncology

A novel lncRNA ROPM-mediated lipid metabolism governs breast cancer stem cell properties

Shuiqing Liu et al.

Summary: The study identified a novel lncRNA, lncROPM, highly expressed in breast cancer stem cells (BCSCs), which regulates PLA2G16 expression to promote phospholipid metabolism and activate multiple signaling pathways involved in maintaining BCSC properties. Targeting the lncROPM-PLA2G16 signaling axis may be a novel therapeutic strategy for breast cancer patients.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Article Cell Biology

Long noncoding RNA NKILA transferred by astrocyte-derived extracellular vesicles protects against neuronal injury by upregulating NLRX1 through binding to mir-195 in traumatic brain injury

Bin He et al.

Aging-US (2021)

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Article Oncology

LncRNA DLEU2 promotes cervical cancer cell proliferation by regulating cell cycle and NOTCH pathway

Min He et al.

Summary: The study identified that lncRNA DLEU2 is significantly upregulated in cervical cancer tissues, promoting cell proliferation and accelerating the cell cycle. Through mechanisms such as inhibiting p53 expression, lncRNA DLEU2 may promote cell cycle progression by inhibiting the activity of the Notch signaling pathway.

EXPERIMENTAL CELL RESEARCH (2021)

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Article Cell Biology

c-MYC-induced long noncoding RNA MEG3 aggravates kidney ischemia-reperfusion injury through activating mitophagy by upregulation of RTKN to trigger the Wnt/β-catenin pathway

Dajun Liu et al.

Summary: The study revealed the crucial role of MEG3 in renal ischemia-reperfusion injury by promoting mitophagy and inducing apoptosis. Furthermore, MEG3 was found to bind with miR-145-5p, leading to upregulation of RTKN and activation of the Wnt/beta -catenin pathway. This positive feedback loop contributes to renal IRI and suggests potential therapeutic targets for treating renal injury.

CELL DEATH & DISEASE (2021)

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Article Cell Biology

A positive feedback loop of lncRNA-RMRP/ZNRF3 axis and Wnt/β-catenin signaling regulates the progression and temozolomide resistance in glioma

Tie Liu et al.

Summary: The study revealed that RMRP is highly expressed in glioma, and its knockdown can inhibit cell proliferation, promote apoptosis, reduce resistance to TMZ, and hinder the growth of glioma xenograft tumors. RMRP down-regulates ZNRF3 in glioma cells, while forming a positive feedback loop with Wnt/β-catenin signaling to regulate TMZ resistance in glioma.

CELL DEATH & DISEASE (2021)

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Article Multidisciplinary Sciences

Myricetin ameliorates ox-LDL-induced HUVECs apoptosis and inflammation via lncRNA GAS5 upregulating the expression of miR-29a-3p

Yunpeng Bai et al.

Summary: The study demonstrated that Myricetin (Myr) preconditioning can prevent ox-LDL-induced injury in HUVECs by regulating GAS5 and miR-29a-3p, showcasing its anti-oxidant and anti-EndMT properties. Myr may have a therapeutic potential for atherosclerosis through inactivating the TLR4/NF-kappa B signaling pathway in ox-LDL-treated HUVECs.

SCIENTIFIC REPORTS (2021)

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Article Pharmacology & Pharmacy

Upregulated UCA1 contributes to oxaliplatin resistance of hepatocellular carcinoma through inhibition of miR-138-5p and activation of AKT/mTOR signaling pathway

Guolin Huang et al.

Summary: The study found that HCC patients with high levels of UCA1 had shorter survival time, and UCA1 may contribute to OXA resistance via miR-138-5p-mediated AKT/mTOR activation.

PHARMACOLOGY RESEARCH & PERSPECTIVES (2021)

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Review Biochemistry & Molecular Biology

LncRNAs: Novel Biomarkers for Pancreatic Cancer

Soudeh Ghafouri-Fard et al.

Summary: Pancreatic cancer is a deadly neoplasm with poor prognosis, and recent research has highlighted the impact of lncRNAs on its progression. Some lncRNAs are oncogenic while others act as tumor suppressors in pancreatic cancer. Dysregulated expression of specific lncRNAs may serve as prognostic markers in patients with this aggressive cancer.

BIOMOLECULES (2021)

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Article Biotechnology & Applied Microbiology

LncRNA RBM5-AS1 Promotes Osteosarcoma Cell Proliferation, Migration, and Invasion

Biyong Deng et al.

Summary: The study found that lncRNA RBM5-AS1 promotes cell proliferation, migration, and invasion in osteosarcoma by targeting RBM5.

BIOMED RESEARCH INTERNATIONAL (2021)

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Article Biochemistry & Molecular Biology

The lncRNA Malat1 regulates microvascular function after myocardial infarction in mice via miR-26b-5p/Mfn1 axis-mediated mitochondrial dynamics

Yuqiong Chen et al.

Summary: This study reveals that Malat1 plays a key role in cardiac microcirculation repair after MI by regulating mitochondrial dynamics and apoptosis through the miR-26b-5p/Mfn1 pathway. Targeted knockdown of Malat1 exacerbates cardiac microvascular dysfunction and impairs cardiac function in MI mice. Overexpression of Mfn1 reverses these effects, highlighting the potential therapeutic value of targeting the Malat1 pathway in MI-related cardiac complications.

REDOX BIOLOGY (2021)

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Article Oncology

LINC01287 facilitates proliferation, migration, invasion and EMT of colon cancer cells via miR-4500/MAP3K13 pathway

Dazhi Fu et al.

Summary: The study identified that LINC01287 is up-regulated in colon cancer patients and associated with tumor progression and prognosis. Silencing LINC01287 inhibited proliferation and migration of colon cancer cells, while overexpression had the opposite effect by regulating the miR-4500/MAP3K13 pathway to promote cancer progression. These findings suggest that LINC01287 may serve as a potential therapeutic target and prognostic marker for colon cancer patients.

BMC CANCER (2021)

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Article Oncology

Long non-coding RNA ARHGAP5-AS1 inhibits migration of breast cancer cell via stabilizing SMAD7 protein

Chen-Long Wang et al.

Summary: The study found that ARHGAP5-AS1 inhibits breast cancer cell migration by stabilizing the SMAD7 protein and may serve as a novel biomarker and potential target for breast cancer in the future.

BREAST CANCER RESEARCH AND TREATMENT (2021)

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Review Biochemistry & Molecular Biology

Long Noncoding RNA GAS5 in Breast Cancer: Epigenetic Mechanisms and Biological Functions

Elena A. Filippova et al.

Summary: Long noncoding RNA GAS5 acts as a tumor suppressor in breast cancer through interactions with proteins, DNA, and various microRNAs. By upregulating suppressor proteins and stimulating apoptosis, GAS5 inhibits tumor growth. Additionally, GAS5 plays a crucial role in regulating key signaling pathways in breast cancer and can enhance drug sensitivity and prognosis through epigenetic mechanisms.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Oncology

LINC00514 promotes lipogenesis and tumor progression in esophageal squamous cell carcinoma by sponging miR-378a-5p to enhance SPHK1 expression

Xin Wang et al.

Summary: Long non-coding RNA LINC00514 plays a critical role in esophageal squamous cell carcinoma by regulating lipogenesis-related proteins to promote cell proliferation and invasion. Targeting the LINC00514/miR-378a-5p/SPHK1 signaling axis may be a novel therapeutic strategy for ESCC patients.

INTERNATIONAL JOURNAL OF ONCOLOGY (2021)

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Article Medicine, Research & Experimental

Long noncoding RNA SNHG3 promotes glioma tumorigenesis by sponging miR-485-5p to upregulate LMX1B expression

Xu Guo et al.

Summary: This study identified that lncRNA SNHG3 regulates the expression of LMX1B by sponging miR-485-5p, promoting the proliferation, migration, and invasion of glioma cells. Targeting the SNHG3/miR-485-5p/LMX1B axis could have therapeutic potential for glioma.

KAOHSIUNG JOURNAL OF MEDICAL SCIENCES (2021)

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Article Oncology

ZIC2 upregulates lncRNA SNHG12 expression to promote endometrial cancer cell proliferation and migration by activating the Notch signaling pathway

Pengyu Cai et al.

Summary: The study found that ZIC2 expression levels were upregulated in tissues and cells of patients with endometrial cancer. Knockdown of ZIC2 inhibited cell proliferation, migration, and invasion, while overexpression promoted these processes. ZIC2 may upregulate SNHG12 expression to activate the Notch signaling pathway and promote the proliferation and migration of endometrial cancer cells.

MOLECULAR MEDICINE REPORTS (2021)

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Article Biotechnology & Applied Microbiology

Effects of curcumin-loaded poly(lactic-co-glycolic acid) nanoparticles in MDA-MB231 human breast cancer cells

Ankur Sharma et al.

Summary: The study demonstrated the significant antitumor effect of curcumin-loaded PLGA nanoparticles on MDA-MB231 human breast cancer cells, showing high encapsulation efficiency and sustained payload release.

NANOMEDICINE (2021)

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Article Cell Biology

Long noncoding RNA DGCR5 involves in tumorigenesis of esophageal squamous cell carcinoma via SRSF1-mediated alternative splicing of Mcl-1

Yuqing Duan et al.

Summary: The study reveals that upregulated lncRNA DGCR5 promotes proliferation, migration, and invasion of ESCC cells while inhibiting apoptosis. DGCR5 directly binds to SRSF1, increasing its stability and initiating important isoform switch of Mcl-1. Cell-derived xenograft model confirms DGCR5's role in facilitating ESCC tumorigenesis.

CELL DEATH & DISEASE (2021)

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Article Multidisciplinary Sciences

Epigenetic regulation of triple negative breast cancer (TNBC) by TGF-β signaling

Radhakrishnan Vishnubalaji et al.

Summary: TGF beta signaling in TNBC is complex and involves regulation of protein coding genes and long non-coding RNA. The study provides a comprehensive analysis of the transcriptional landscape in response to TGF beta activation and inhibition, revealing potential targets for TGF beta regulation in TNBC.

SCIENTIFIC REPORTS (2021)

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Article Neurosciences

RBM5-AS1 promotes radioresistance in medulloblastoma through stabilization of SIRT6 protein

Chuanying Zhu et al.

Summary: This study identified RBM5-AS1 as an inducer of stemness and radioresistance in medulloblastoma. Targeting RBM5-AS1 could potentially overcome resistance to radiotherapy in this malignancy by reducing stemness and enhancing radiation-induced DNA damage.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2021)

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Article Biotechnology & Applied Microbiology

Lang non-coding RNA (LncRNA) CASC/microRNA(miR)-590-3p/sine oculis homeobox 1 (SIX1)/NF-kappa B axis promotes proliferation and migration in breast cancer

Jingzhi Chang et al.

Summary: The study demonstrated that CASC9 affects cell growth, invasion, migration, and apoptosis of breast cancer cells by regulating miR-590-3p and SIX1 genes.

BIOENGINEERED (2021)

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Article Biotechnology & Applied Microbiology

Over-expression of long non-coding RNA insulin-like growth factor 2-antisense suppressed hepatocellular carcinoma cell proliferation and metastasis by regulating the microRNA-520h/cyclin-dependent kinase inhibitor 1A signaling pathway

Zhen Huang et al.

Summary: IGF2-AS serves as a tumor-suppressor in HCC, and lower IGF2-AS expression is associated with poor prognosis of HCC patients; IGF2-AS inhibits HCC oncogenesis and development through the IGF2-AS/miR-520h/CDKN1A pathway.

BIOENGINEERED (2021)

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Article Respiratory System

LncRNA CASC2 is involved in the development of chronic obstructive pulmonary disease via targeting miR-18a-5p/IGF1 axis

Panpan Liu et al.

Summary: CASC2 is downregulated in COPD patients and may serve as a promising biomarker for disease diagnosis. The overexpression of CASC2 can inhibit bronchial epithelial cell apoptosis and inflammation by targeting the miR-18a-5p/IGF1 axis.

THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE (2021)

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Review Biochemistry & Molecular Biology

Partial EMT in Squamous Cell Carcinoma: A Snapshot

Chengcheng Liao et al.

Summary: Partial EMT is a plastic state in cancer cells where both epithelial and mesenchymal characteristics are exhibited, regulated by various pathways and molecules, leading to aggressive tumorigenic properties and high stemness, resulting in therapy resistance and metastasis.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Article Medicine, Research & Experimental

Long non-coding RNA IGF2-AS represses breast cancer tumorigenesis by epigenetically regulating IGF2

Yanan Zhang et al.

Summary: The study demonstrates that IGF2-AS plays a tumor-suppressive role in breast cancer, inhibiting the expression of IGF2 gene and influencing the PI3K/AKT/mTOR signaling pathway, with significant impact on tumor development.

EXPERIMENTAL BIOLOGY AND MEDICINE (2021)

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Article Respiratory System

Targeting MALAT1 and miRNA-181a-5p for the intervention of acute lung injury/acute respiratory distress syndrome

Yaling Liu et al.

Summary: In patients with ALI/ARDS, MALAT1 is upregulated while miR-181a-5p is downregulated. miR-181a-5p exerts therapeutic effects by inhibiting Fas and cell apoptosis, while MALAT1 negatively regulates miR-181a-5p. Both MALAT1 antagonism and miR-181a-5p could be potential therapeutic strategies for ALI/ARDS.

RESPIRATORY RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Micropeptide CIP2A-BP encoded by LINC00665 inhibits triple-negative breast cancer progression

Binbin Guo et al.

EMBO JOURNAL (2020)

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Article Oncology

LncRNA CASC9 Suppressed the Apoptosis of Gastric Cancer Cells through Regulating BMI1

Jun Fang et al.

PATHOLOGY & ONCOLOGY RESEARCH (2020)

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Article Biochemistry & Molecular Biology

SNHG3 Functions as miRNA Sponge to Promote Breast Cancer Cells Growth Through the Metabolic Reprogramming

Yan Li et al.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2020)

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Article Medicine, Research & Experimental

Long non-coding RNA RBM5-AS1 promotes the aggressive behaviors of oral squamous cell carcinoma by regulation of miR-1285-3p/YAP1 axis

Chenxi Li et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Medicine, Research & Experimental

Active fraction of Polyrhachis vicina Rogers (AFPR) suppressed breast cancer growth and progression via regulating EGR1/lncRNA-NKILA/NF-κB axis

Dong-mei Li et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Cell Biology

Downregulation of LncRNA NORAD promotes Ox-LDL-induced vascular endothelial cell injury and atherosclerosis

Weihua Bian et al.

AGING-US (2020)

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Article Medicine, Research & Experimental

LncRNA SNHG3 promotes the growth and metastasis of colorectal cancer by regulating miR-539/RUNX2 axis

Dacheng Wen et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Biochemistry & Molecular Biology

ADSC-Exos containing MALAT1 promotes wound healing by targeting miR-124 through activating Wnt/β-catenin pathway

Lin He et al.

BIOSCIENCE REPORTS (2020)

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Article Biochemistry & Molecular Biology

LncRNA CASC2 inhibits hypoxia-induced pulmonary artery smooth muscle cell proliferation and migration by regulating the miR-222/ING5 axis

Yan Han et al.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2020)

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Article Oncology

Long noncoding RNA CASC9 promotes the proliferation and metastasis of papillary thyroid cancer via sponging miR-488-3p

Yonghui Chen et al.

CANCER MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Exosomal Long Non-Coding RNAs in Lung Diseases

Christophe Poulet et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Cell Biology

LncRNA HOTTIP facilitates the stemness of breast cancer via regulation of miR-148a-3p/WNT1 pathway

Li Han et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Medical Laboratory Technology

Long noncoding RNAs in osteosarcoma via various signaling pathways

Jinming Han et al.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2020)

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Article Cell Biology

SMAD4 activates Wnt signaling pathway to inhibit granulosa cell apoptosis

Xing Du et al.

CELL DEATH & DISEASE (2020)

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Article Biochemistry & Molecular Biology

LncRNA EGOT decreases breast cancer cell viability and migration via inactivation of the Hedgehog pathway

Shuang Qiu et al.

FEBS OPEN BIO (2020)

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Review Endocrinology & Metabolism

MicroRNAs as Biomarker for Breast Cancer

Taru Aggarwal et al.

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS (2020)

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Article Biochemistry & Molecular Biology

被撤回的出版物: LncRNA BCRT1 promotes breast cancer progression by targeting miR-1303/PTBP3 axis (Retracted article. See vol. 21, 2022)

Yiran Liang et al.

MOLECULAR CANCER (2020)

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Article Clinical Neurology

Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates

Paula Garcia-Huerta et al.

ACTA NEUROPATHOLOGICA (2020)

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Review Medicine, Research & Experimental

The role of long non-coding RNA CASC2 in the carcinogenesis process

Soudeh Ghafouri-Fard et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Pharmacology & Pharmacy

The HOTTIP (HOXA transcript at the distal tip) lncRNA: Review of oncogenic roles in human

Soudeh Ghafouri-Fard et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Cell Biology

LncRNA SNHG3 promotes bladder cancer proliferation and metastasis through miR-515-5p/GINS2 axis

Guangcheng Dai et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Oncology

Long noncoding RNA LINC00514 accelerates pancreatic cancer progression by acting as a ceRNA of miR-28-5p to upregulate Rap1b expression

Qing Han et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Article Oncology

Long non-coding RNA SNHG3 promotes breast cancer cell proliferation and metastasis by binding to microRNA-154-3p and activating the notch signaling pathway

Hongnan Jiang et al.

BMC CANCER (2020)

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Review Pharmacology & Pharmacy

Targeting the PI3K/AKT/mTOR Pathway in Hormone-Positive Breast Cancer

Sara E. Nunnery et al.

DRUGS (2020)

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Article Gastroenterology & Hepatology

The Long Noncoding RNA CCAT2 Induces Chromosomal Instability Through BOP1-AURKB Signaling

Baoqing Chen et al.

GASTROENTEROLOGY (2020)

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Review Biochemistry & Molecular Biology

Targeting Autophagy in Breast Cancer

Stefania Cocco et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Cell Biology

A lncRNA prognostic signature associated with immune infiltration and tumour mutation burden in breast cancer

Zijian Liu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Oncology

Linc00514 promotes breast cancer metastasis and M2 polarization of tumor-associated macrophages via Jagged1-mediated notch signaling pathway

Sifeng Tao et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Article Oncology

lncRNA CASC2 inhibits lipopolysaccharide-induced acute lung injury via miR-27b/TAB2 axis

Xiaoquan Li et al.

MOLECULAR MEDICINE REPORTS (2020)

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Article Multidisciplinary Sciences

LncRNA Malat1 inhibition of TDP43 cleavage suppresses IRF3-initiated antiviral innate immunity

Wei Liu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Cell Biology

Long non-coding RNA CASC9 promotes gefitinib resistance in NSCLC by epigenetic repression of DUSP1

Zhenyao Chen et al.

CELL DEATH & DISEASE (2020)

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Review Biochemistry & Molecular Biology

LncRNAs in Ovarian Cancer Progression, Metastasis, and Main Pathways: ceRNA and Alternative Mechanisms

Eleonora A. Braga et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Multidisciplinary Sciences

Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis

Junmei Yi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Cell Biology

Comp34 displays potent preclinical antitumor efficacy in triple-negative breast cancer via inhibition of NUDT3-AS4, a novel oncogenic long noncoding RNA

Qiongyu Hao et al.

CELL DEATH & DISEASE (2020)

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Article Cell Biology

LncRNA LINC00472 regulates cell stiffness and inhibits the migration and invasion of lung adenocarcinoma by binding to YBX1

Xiangying Deng et al.

CELL DEATH & DISEASE (2020)

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Article Oncology

Long Non-Coding RNA NKILA Reduces Oral Squamous Cell Carcinoma Development Through the NF-KappaB Signaling Pathway

Daoyong Hu et al.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2020)

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Article Biochemistry & Molecular Biology

NKILA, a prognostic indicator, inhibits tumor metastasis by suppressing NF-κB/Slug mediated epithelial-mesenchymal transition in hepatocellular carcinoma

Ronggao Chen et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2020)

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Article Medicine, Research & Experimental

m6A RNA modification modulates PI3K/Akt/mTOR signal pathway in Gastrointestinal Cancer

Qijie Zhao et al.

THERANOSTICS (2020)

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Article Oncology

LncRNA EGOT Promotes Tumorigenesis Via Hedgehog Pathway in Gastric Cancer

Wei Peng et al.

PATHOLOGY & ONCOLOGY RESEARCH (2019)

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Article Oncology

Upregulation of lncRNA CASC2 Suppresses Cell Proliferation and Metastasis of Breast Cancer via Inactivation of the TGF-β Signaling Pathway

Yang Zhang et al.

ONCOLOGY RESEARCH (2019)

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Article Oncology

ER upregulates the expression of long non-coding RNA LINC00472 which suppresses the phosphorylation of NF-B in breast cancer

Zhanwei Wang et al.

BREAST CANCER RESEARCH AND TREATMENT (2019)

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Article Medicine, Research & Experimental

LncRNA SNHG3/miRNA-151a-3p/RAB22A axis regulates invasion and migration of osteosarcoma

Shengnai Zheng et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Review Biochemistry & Molecular Biology

LncRNA HOTAIR in Tumor Microenvironment: What Role?

Gerardo Botti et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Cell Biology

Impaired autophagic degradation of lncRNA ARHGAP5-AS1 promotes chemoresistance in gastric cancer

Liyuan Zhu et al.

CELL DEATH & DISEASE (2019)

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Article Oncology

Delphinidin suppresses breast carcinogenesis through the HOTAIR/microRNA-34a axis

Bin Han et al.

CANCER SCIENCE (2019)

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Review Biochemistry & Molecular Biology

TGF--Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis

Yang Hao et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Cell Biology

NF-κB/NKILA signaling modulates the anti-cancerous effects of EZH2 inhibition

Suzann Duan et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

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Article Multidisciplinary Sciences

The insulin-like growth factor 2 gene in mammals: Organizational complexity within a conserved locus

Kabita Baral et al.

PLOS ONE (2019)

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Article Cell Biology

Overexpressed pseudogenes, DUXAP8 and DUXAP9, promote growth of renal cell carcinoma and serve as unfavorable prognostic biomarkers

Jing Chen et al.

AGING-US (2019)

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Review Medicine, Research & Experimental

UCA1 long non-coding RNA: An update on its roles in malignant behavior of cancers

Soudeh Ghafouri-Fard et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Article Oncology

m6A mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the MALAT1-miR-1914-3p-YAP axis to induce NSCLC drug resistance and metastasis

Dan Jin et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

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Article Multidisciplinary Sciences

Down-regulation of long non-coding RNA HOTAIR sensitizes breast cancer to trastuzumab

Tianwen Chen et al.

SCIENTIFIC REPORTS (2019)

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Review Cell & Tissue Engineering

The shift in the balance between osteoblastogenesis and adipogenesis of mesenchymal stem cells mediated by glucocorticoid receptor

Lizhi Han et al.

STEM CELL RESEARCH & THERAPY (2019)

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Article Toxicology

Mitogen-Activated Protein Kinase (MAPK): New Insights in Breast Cancer

Huanyu Lu et al.

JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY (2019)

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Article Immunology

LncRNA SNHG3 promotes cell growth by sponging miR-196a-5p and indicates the poor survival in osteosarcoma

Jun Chen et al.

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY (2019)

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Article Medicine, General & Internal

LncRNA SNHG3 Promotes Hepatocellular Tumorigenesis by Targeting miR-326

Qian Zhao et al.

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE (2019)

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Article Medicine, Research & Experimental

Long noncoding RNA GAS5 induces abdominal aortic aneurysm formation by promoting smooth muscle apoptosis

Xiang He et al.

THERANOSTICS (2019)

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Article Oncology

Downregulated Long Noncoding RNA DGCR5 Acts as a New Promising Biomarker for the Diagnosis and Prognosis of Ovarian Cancer

Hongxiao Chen et al.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2019)

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Article Biology

Polydatin protects H9c2 cells from hypoxia-induced injury via up-regulating long non-coding RNA DGCR5

Jinhua Dai et al.

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (2019)

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Article Medicine, Research & Experimental

LncCCAT1 Promotes Breast Cancer Stem Cell Function through Activating WNT/beta-catenin Signaling

Tingting Tang et al.

THERANOSTICS (2019)

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Article Biochemistry & Molecular Biology

LncRNA CASC9 promotes esophageal squamous cell carcinoma metastasis through upregulating LAMC2 expression by interacting with the CREB-binding protein

Yan Liang et al.

CELL DEATH AND DIFFERENTIATION (2018)

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Article Oncology

LncRNA NKILA suppresses TGF-β-induced epithelial-mesenchymal transition by blocking NF-κB signaling in breast cancer

Wei Wu et al.

INTERNATIONAL JOURNAL OF CANCER (2018)

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Article Oncology

LINC01287/miR-298/STAT3 feedback loop regulates growth and the epithelial-tomesenchymal transition phenotype in hepatocellular carcinoma cells

Yichao Mo et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)

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Article Oncology

Targeting the MALAT1/PARP1/LIG3 complex induces DNA damage and apoptosis in multiple myeloma

Yi Hu et al.

LEUKEMIA (2018)

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Article Genetics & Heredity

A high throughput, functional screen of human Body Mass Index GWAS loci using tissue-specific RNAi Drosophila melanogaster crosses

Thomas J. Baranski et al.

PLOS GENETICS (2018)

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Review Cell & Tissue Engineering

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