期刊
MOLECULAR SYSTEMS BIOLOGY
卷 12, 期 7, 页码 -出版社
WILEY
DOI: 10.15252/msb.20156651
关键词
cellular imaging; computational biology; deep learning; machine learning; regulatory genomics
资金
- European Molecular Biology Laboratory
- European Regional Development Fund through the BioMedIT project
- Estonian Research Council [IUT34-4]
- Wellcome Trust
- European Research Council [N635290]
Technological advances in genomics and imaging have led to an explosion of molecular and cellular profiling data from large numbers of samples. This rapid increase in biological data dimension and acquisition rate is challenging conventional analysis strategies. Modern machine learning methods, such as deep learning, promise to leverage very large data sets for finding hidden structure within them, and for making accurate predictions. In this review, we discuss applications of this new breed of analysis approaches in regulatory genomics and cellular imaging. We provide background of what deep learning is, and the settings in which it can be successfully applied to derive biological insights. In addition to presenting specific applications and providing tips for practical use, we also highlight possible pitfalls and limitations to guide computational biologists when and how to make the most use of this new technology.
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