期刊
PATHOLOGY RESEARCH AND PRACTICE
卷 247, 期 -, 页码 -出版社
ELSEVIER GMBH
DOI: 10.1016/j.prp.2023.154572
关键词
Glioblastoma; GSCs; USP18; Malignant phenotypes; Prognosis
类别
In this study, it was found that USP18 was up-regulated in glioblastoma, promoting the growth and proliferation of glioblastoma stem cells (GSCs), affecting the epithelial-mesenchymal transition (EMT), and being associated with poor clinical prognosis of patients.
Glioblastoma (GBM) is the most malignant primary brain tumor. The 5-year survival rate of the patients is poor, and they are prone to relapse and the treatment is limited. Therefore, the search for biological targets is one of the key measures for the treatment and prognosis of GBM. Ubiquitin-specific peptidase 18 (USP18) plays a regulatory role in tumorigenesis. In this study, we found that USP18 was up-regulated in GBM, promoted the growth and proliferation of glioblastoma stem cells (GSCs), affected the epithelial-mesenchymal transition (EMT), and was associated with poor clinical prognosis of patients. Finally, our findings reveal a critical role for USP18 in GBM malignancy, targeting USP18 may open new avenues for GBM treatment.
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