Cellular mechanisms in the pathogenesis of interstitial lung diseases

The interstitial lung diseases (ILDs) are a large, heterogeneous group of several hundred generally rare pulmonary pathologies, which show injury, inflammation and/or scarring in the lung. Although the aetiology of these disorders remains largely unknown, various cellular mechanisms have an important role in pathogenesis of fibrosis on the background of occupational, environmental and genetic factors. We have tried to provide new insights into the interactions and cellular contributions, analysing the roles of various cells in the pathogenesis of idiopathic pulmonary fibrosis.

Automated summary

Interstitial lung diseases (ILDs) are a group of rare pulmonary pathologies that involve injury, inflammation, and scarring in the lungs. The exact causes of these diseases are largely unknown, but various cellular mechanisms play important roles in the development of fibrosis, influenced by occupational, environmental, and genetic factors. This study aims to provide new insights into the interactions and cellular contributions in the pathogenesis of idiopathic pulmonary fibrosis.