Colloidal, Functional, Piezoelectric BaTiO3-Au Nanohybrid for Wireless Cell Therapy

Ultrasound-assisted reactive oxygen species (ROS) generation from piezoelectric nanomaterial offers unique wireless therapeutic approach in remote places. In the previous work, piezoelectric barium titanate (BaTiO3) nanorod have been synthesized and used for wireless cell therapy. However, the piezoelectric property of BaTiO3 nanorod needs further improvement for diverse applications. In this work, it is shown that gold nanoparticle conjugation with BaTiO3 nanorod (BaTiO3-Au) can significantly enhance the piezoelectric performance with the piezoelectric constant value of 110 pm V-1. The colloidal BaTiO3-Au is further functionalized with folate for selective targeting of folate-overexpressed cancer cells and used for wireless cell therapy via intracellular ROS generation under ultrasound exposure. The synthesized colloidal nanohybrid can be used for various therapeutic applications.

Automated summary

Ultrasound-assisted ROS generation from piezoelectric nanomaterial provides a unique wireless therapeutic approach in remote areas. BaTiO3-Au nanorods were synthesized to enhance the piezoelectric performance for diverse applications. The functionalized nanohybrid with folate can selectively target folate-overexpressed cancer cells and generate intracellular ROS under ultrasound exposure for wireless cell therapy.