4.6 Article

Allergic reactions to tick saliva components in zebrafish model

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Dermatology

Expression of interleukin-1β, interleukin-4, interferon-γ and tumour necrosis factor α in different tissue in a dinitrochlorobenzene-induced ear swelling test in mice

Chun-Lian Li et al.

Summary: The study aimed to investigate the expression of IL-1 beta, IL-4, IFN-gamma, and TNF-alpha in different tissues in a DNCB-induced ear swelling test in mice, and evaluate the correlation between cytokine expression and the degree of ear swelling. The results showed a linear positive correlation between the swelling index of the mouse lateral ear and the DNCB challenge concentration. High expression of IL-1 beta and IL-4 in the lateral ear tissue was positively correlated with the ear swelling index. IFN-gamma and TNF-alpha showed no significant correlation with the ear swelling index. In conclusion, there is a correlation between ear swelling in mice, DNCB concentration, and the expression of IL-1 beta and IL-4 in lateral ear tissue.

SKIN RESEARCH AND TECHNOLOGY (2023)

Article Allergy

Tick bite as a risk factor for alpha-gal-specific immunoglobulin E antibodies and development of alpha-gal syndrome

Gilbert J. Kersh et al.

Summary: Tick bites are associated with alpha-gal syndrome (AGS) and elevated alpha-gal-specific IgE levels. People who live in wooded areas, spend more time outdoors in wooded areas, and have a history of multiple tick bites are at higher risk for developing AGS.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2023)

Review Immunology

Where's the Beef? Understanding Allergic Responses to Red Meat in Alpha-Gal Syndrome

Audrey S. Carson et al.

Summary: Alpha-gal syndrome is a collection of symptoms related to an allergic reaction to galactose-alpha-1,3 galactose. This reaction occurs after consuming mammalian meat and other mammal-derived food products. This article reviews the role of tick bites in the development of this allergic reaction and discusses the impact of alpha-gal glycosylation on digestion, metabolism, and allergic symptoms.

JOURNAL OF IMMUNOLOGY (2022)

Review Immunology

Tick Saliva and Salivary Glands: What Do We Know So Far on Their Role in Arthropod Blood Feeding and Pathogen Transmission

Girish Neelakanta et al.

Summary: Ticks are blood-sucking arthropods that have developed various strategies to obtain blood meals from vertebrate hosts. On one hand, they attach to the host, secrete molecules in their saliva, and feed while on the other hand, host defenses will try to counter-attack and stop tick feeding. Understanding the biology of tick blood feeding and molecular interactions at the tick-host interface is crucial for developing transmission-blocking vaccines against vector-borne pathogens.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

Review Allergy

Current and Future Strategies for the Diagnosis and Treatment of the Alpha-Gal Syndrome (AGS)

Rita Vaz-Rodrigues et al.

Summary: The alpha-Gal syndrome is an IgE-mediated delayed allergic reaction caused by foods containing the oligosaccharide alpha-Gal. The diagnosis and treatment of AGS are challenging due to delayed reactions and a wide variety of clinical history. Various diagnostic and research methods are being used, and future preventive tools, such as identification of tick salivary molecules, are being discussed.

JOURNAL OF ASTHMA AND ALLERGY (2022)

Review Immunology

The Meat of the Matter: Understanding and Managing Alpha-Gal Syndrome

Jessica D. Macdougall et al.

Summary: Alpha-gal syndrome is an unconventional food allergy associated with tick bites. It leads to hypersensitivity responses to the glycan galactose-alpha-1,3-galactose (alpha-gal) rather than food proteins. This review examines the immune cell populations involved and discusses management strategies, as well as the impact on quality of life.

IMMUNOTARGETS AND THERAPY (2022)

Review Biochemical Research Methods

Characterization of tick salivary gland and saliva alphagalactome reveals candidate alpha-gal syndrome disease biomarkers

Margarita Villar et al.

Summary: Ticks produce proteins with alpha-Gal modifications in saliva during feeding, which may serve as potential biomarkers for AGS. These proteins have potential implications in AGS and other disorders, as well as a protective capacity against tick infestations and pathogen infection.

EXPERT REVIEW OF PROTEOMICS (2021)

Article Immunology

Alpha-Gal Syndrome: Involvement of Amblyomma americanum α-D-Galactosidase and β-1,4 Galactosyltransferase Enzymes in α-Gal Metabolism

Surendra Raj Sharma et al.

Summary: This study investigated the functional roles of tick enzymes ADGal and beta-1,4GalT in endogenous alpha-gal production, carbohydrate metabolism, and N-glycan profile in lone-star tick. The silence of ADGal led to downregulation of genes involved in galactose metabolism in tick, showing a significant reduction in alpha-gal levels in tick salivary glands. However, beta-1,4GalT-silenced tick salivary glands did not show significant difference in alpha-gal levels, providing insight into their roles in alpha-gal production and presentation in ticks and the probable involvement in the onset of AGS.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

Review Pediatrics

Alpha-Gal Syndrome in Children: Peculiarities of a Tick-Borne Allergic Disease

Francesca Saretta et al.

Summary: Alpha-gal syndrome is an allergic syndrome with immediate and delayed hypersensitivity reactions. It is often misdiagnosed, especially in tick-endemic areas, with tick bites being a related factor. Diagnosis relies on specific IgE testing, and elimination diet may improve symptoms.

FRONTIERS IN PEDIATRICS (2021)

Review Infectious Diseases

Tick exposures and alpha-gal syndrome: A systematic review of the evidence

Ian Young et al.

Summary: This study summarized the evidence on Alpha-gal syndrome (AGS) caused by tick bites in recent years, identifying AGS cases in different countries, with a high number in the United States, Spain, Sweden, and France. Most studies were case reports or series, with hives and anaphylaxis being the main symptoms reported by the cases.

TICKS AND TICK-BORNE DISEASES (2021)

Article Infectious Diseases

Characterization of the anti- ? -Gal antibody profile in association with Guillain-Barr ? e syndrome, implications for tick-related allergic reactions

Ivan Pacheco et al.

Summary: Humans evolved by losing the ability to synthesize a certain sugar molecule, which led to the development of a protective response against pathogens with a specific protein modification, but also resulted in a newly diagnosed allergic disease related to mammalian meat consumption. Research found that patients with neurological disorders had significantly decreased antibody levels to the sugar molecule, while patients with tick-associated allergies did not show significant differences.

TICKS AND TICK-BORNE DISEASES (2021)

Article Parasitology

Mosquito vector proteins homologous to α1-3 galactosyl transferases of tick vectors in the context of protective immunity against malaria and hypersensitivity to vector bites

Ranjan Ramasamy

Summary: The study found that two important mosquito vectors (Aedes aegypti and Anopheles gambiae) possess proteins similar to the three Ixodes scapularis proteins with alpha 1-3 GT activity, suggesting they may synthesize glycoconjugates containing alpha -gal that are transferred to sporozoite surfaces. However, Plasmodium parasites lack proteins with similar activity, indicating that the alpha -gal on sporozoite surfaces may be acquired from mosquito glycoconjugates rather than de novo synthesis by the parasites.

PARASITES & VECTORS (2021)

Review Immunology

Tick Saliva and the Alpha-Gal Syndrome: Finding a Needle in a Haystack

Surendra Raj Sharma et al.

Summary: Ticks and tick-borne diseases pose significant public health concerns, with bioactive molecules in tick saliva facilitating the transmission of pathogens such as the alpha-gal antigen. Alpha-gal syndrome (AGS), a newly reported food allergy, is characterized by IgE antibody-directed hypersensitivity against alpha-gal, a sugar molecule found in tick saliva. While the alpha-gal antigen has been identified in various tick species, the immune mechanisms linking tick bites to alpha-gal-specific IgE production remain poorly understood.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

Article Immunology

Characterization by Quantitative Serum Proteomics of Immune-Related Prognostic Biomarkers for COVID-19 Symptomatology

Margarita Villar et al.

Summary: The study used quantitative proteomics and data analysis algorithms to analyze serum protein profiles in COVID-19 patients, identifying dysregulated proteins and processes associated with the disease. Results highlighted the increasing representation of dysregulated serum proteins and biological processes with COVID-19 symptomatology severity from asymptomatic to severe cases.

FRONTIERS IN IMMUNOLOGY (2021)

Article Agriculture, Dairy & Animal Science

Enterocytes in Food Hypersensitivity Reactions

Maja Krstic Ristivojevic et al.

Summary: Food hypersensitivity is increasing, and enterocytes are now recognized to play a role not only in nutrient absorption, but also in immune responses. Enterocytes are crucial for maintaining oral tolerance and food hypersensitivity.

ANIMALS (2021)

Article Chemistry, Medicinal

Probiotic Bacteria with High Alpha-Gal Content Protect Zebrafish against Mycobacteriosis

Ivan Pacheco et al.

Summary: High alpha-Gal content probiotics, such as Aeromonas veronii and Pseudomonas entomophila, have been found to be safe and effective in controlling Mycobacterium marinum in fish by regulating immunity and metabolism mechanisms.

PHARMACEUTICALS (2021)

Review Medicine, General & Internal

IgE-mediated food allergy throughout life

Ebru Celebioglu et al.

Summary: Food allergy (FA) has become a global increasing problem over the past 20 years, with the frequency rising in both children and adults. The most common form is IgE-mediated FA, which can range from mild symptoms like hives to life-threatening conditions like anaphylaxis.

TURKISH JOURNAL OF MEDICAL SCIENCES (2021)

Article Infectious Diseases

Ixodes scapularis saliva components that elicit responses associated with acquired tick-resistance

Sukanya Narasimhan et al.

TICKS AND TICK-BORNE DISEASES (2020)

Article Biochemistry & Molecular Biology

Pilocarpine Induced Behavioral and Biochemical Alterations in Chronic Seizure-Like Condition in Adult Zebrafish

Yam Nath Paudel et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Immunology

Allergic Reactions and Immunity in Response to Tick Salivary Biogenic Substances and Red Meat Consumption in the Zebrafish Model

Marinela Contreras et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

Article Biochemistry & Molecular Biology

Tick and Host Derived Compounds Detected in the Cement Complex Substance

Margarita Villar et al.

BIOMOLECULES (2020)

Review Immunology

B Cell Responses in the Development of Mammalian Meat Allergy

Jessica L. Chandrasekhar et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Biochemistry & Molecular Biology

Are there specific antibodies against Neu5Gc epitopes in the blood of healthy individuals?

Polina Obukhova et al.

GLYCOBIOLOGY (2020)

Review Infectious Diseases

Wonders of tick saliva

Patricia A. Nuttall

TICKS AND TICK-BORNE DISEASES (2019)

Review Immunology

Environmental and Molecular Drivers of the α-Gal Syndrome

Alejandro Cabezas-Cruz et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Biotechnology & Applied Microbiology

?Zebrafish as an animal model for food safety research: trends in the animal research?

Ricardo Lacava Bailone et al.

FOOD BIOTECHNOLOGY (2019)

Article Developmental Biology

Effect of the Dietary Inclusion of Soybean Components on the Innate Immune System in Zebrafish

Pamela Fuentes-Appelgren et al.

ZEBRAFISH (2014)

Article Veterinary Sciences

Anesthesia and Euthanasia in Zebrafish

Monte Matthews et al.

ILAR JOURNAL (2012)

Article Allergy

Relationship between red meat allergy and sensitization to gelatin and galactose-α-1,3-galactose

Raymond James Mullins et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2012)

Article Multidisciplinary Sciences

Crystal Structure of Der f 7, a Dust Mite Allergen from Dermatophagoides farinae

Kang Wei Tan et al.

PLOS ONE (2012)

Article Biochemistry & Molecular Biology

Changes in the Repertoire of Natural Antibodies Caused by Immunization with Bacterial Antigens

N. V. Shilova et al.

BIOCHEMISTRY-MOSCOW (2011)

Article Medicine, General & Internal

An association between tick bite reactions and red meat allergy in humans

Sheryl A. Van Nunen et al.

MEDICAL JOURNAL OF AUSTRALIA (2009)

Article Medicine, General & Internal

Cetuximab-induced anaphylaxis and IgE specific for galactose-α-1,3-galactose

Christine H. Chung et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

Article Biochemical Research Methods

In-gel digestion for mass spectrometric characterization of proteins and proteomes

Andrej Shevchenko et al.

NATURE PROTOCOLS (2006)

Article Entomology

How much pilocarpine contaminates pilocarpine-induced tick saliva?

JMC Ribeiro et al.

MEDICAL AND VETERINARY ENTOMOLOGY (2004)