期刊
MOLECULAR REPRODUCTION AND DEVELOPMENT
卷 83, 期 10, 页码 860-874出版社
WILEY
DOI: 10.1002/mrd.22663
关键词
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资金
- Eunice Kennedy Shriver National Institute of Child Health and Human Development [NIH RO1 HD38082, HD44044]
- Lalor Foundation
Dr. Min Chue Chang's contributions to the field of reproductive biology set the stage for the development of the contraceptive pill and in vitro fertilization. Throughout his publications, Dr. Chang was also able to transmit his view of the fertilization process in ways that organized research for newer generations of reproductive biologists. Particularly relevant for the achievement of in vitro fertilization in mammals was the discovery that the sperm required a period of residence in the female tract to become fertilization-competent; Dr. Chang and Dr. Austin, in Australia, independently reported this process, now known as sperm capacitation. This review discusses Dr. Chang's views on capacitation, and puts them in the context of recent advances in the understanding of the molecular basis of this process. Mol. Reprod. Dev. 83: 860-874, 2016 (c) 2016 Wiley Periodicals, Inc.
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