Pancreatic duct pressure: A review of technical aspects and clinical significance

Pancreatic duct pressure (PDP) dynamics comprise an intricately modulated system that helps maintain homeostasis of pancreatic function. It is affected by various factors, including the rate of pancreatic fluid secretion, patency of the ductal system, sphincter of Oddi function, and pancreatic fluid characteristics. Disease states such as acute and chronic pancreatitis can alter the normal PDP dynamics. Ductal hypertension or increased PDP is suspected to be involved in the pathogenesis of pancreatic pain, endocrine and exocrine pancreatic insufficiency, and recurrent pancreatitis. This review provides a comprehensive appraisal of the available literature on PDP, including the methods used in the measurement and clinical implications of elevated PDP.(c) 2023 IAP and EPC. Published by Elsevier B.V. All rights reserved.

Automated summary

This review evaluates the dynamics of pancreatic duct pressure (PDP), including measurement methods and the clinical implications of elevated PDP. The study found that ductal hypertension is associated with pancreatic diseases and symptoms such as pancreatic pain and pancreatic insufficiency.