期刊
MOLECULAR PSYCHIATRY
卷 21, 期 12, 页码 1710-1716出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/mp.2015.227
关键词
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资金
- Canadian Institutes of Health Research [103703, 106469, 64410]
- Nova Scotia Health Research Foundation, Dalhousie Clinical Research Scholarship
- Research Council of Norway
- South East Norway Health Authority
- Kristian Gerhard Jebsen Foundation
- European Community [602450]
- National Centre for Mental Health (NCMH)
- Bipolar Disorder Research Network (BDRN)
- French National Agency for Research (MNP)
- Fondamental Foundation
- Swedish Medical Research Council
- Swedish foundation for Strategic Research
- Swedish Brain foundation
- Swedish Federal Government under the LUA/ALF
- NIH [MH085667, R01MH075007, R01MH095454, P30NS062691, K23MH074644-01, U54 EB020403]
- Joanne and George Miller Family Endowed Term Chair
- NIMH [R01 MH090553]
- Brain Behavior Research Foundation
- NIBIB
- NCI
- [R01MH107703]
- [K23MH098130]
- [K08MH086786]
- Medical Research Council [MR/L010305/1, MR/K026992/1, 1578661] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0513-10010] Funding Source: researchfish
Considerable uncertainty exists about the defining brain changes associated with bipolar disorder (BD). Understanding and quantifying the sources of uncertainty can help generate novel clinical hypotheses about etiology and assist in the development of biomarkers for indexing disease progression and prognosis. Here we were interested in quantifying case-control differences in intracranial volume (ICV) and each of eight subcortical brain measures: nucleus accumbens, amygdala, caudate, hippocampus, globus pallidus, putamen, thalamus, lateral ventricles. In a large study of 1710 BD patients and 2594 healthy controls, we found consistent volumetric reductions in BD patients for mean hippocampus (Cohen's d= -0.232; P = 3.50 x 10(-7)) and thalamus (d= -0.148; P = 4.27 x 10(-3)) and enlarged lateral ventricles (d= -0.260; P = 3.93 x 10(-5)) in patients. No significant effect of age at illness onset was detected. Stratifying patients based on clinical subtype (BD type I or type II) revealed that BDI patients had significantly larger lateral ventricles and smaller hippocampus and amygdala than controls. However, when comparing BDI and BDII patients directly, we did not detect any significant differences in brain volume. This likely represents similar etiology between BD subtype classifications. Exploratory analyses revealed significantly larger thalamic volumes in patients taking lithium compared with patients not taking lithium. We detected no significant differences between BDII patients and controls in the largest such comparison to date. Findings in this study should be interpreted with caution and with careful consideration of the limitations inherent to meta-analyzed neuroimaging comparisons.
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