Joint-adjacent subcutaneous adipose tissue - An obesity-related imaging biomarker associated with structural osteoarthritis progression?

Review Orthopedics

Association between weight gain and knee osteoarthritis: a systematic review

P. Solanki et al.

Summary: This study conducted a systematic review and data synthesis, showing that weight gain in adults is associated with increased clinical and structural KOA and TKR. Preventing weight gain should be considered to improve outcomes in KOA.

OSTEOARTHRITIS AND CARTILAGE (2023)

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Article Rheumatology

Association of Decrease in Body Mass Index With Reduced Incidence and Progression of the Structural Defects of Knee Osteoarthritis: A Prospective Multi-Cohort Study

Zubeyir Salis et al.

Summary: This study aimed to define the association between change in body mass index (BMI) and the incidence and progression of the structural defects of knee osteoarthritis as assessed by radiography. The results showed that change in BMI was positively associated with both the incidence and progression of knee osteoarthritis.

ARTHRITIS & RHEUMATOLOGY (2023)

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Article Health Care Sciences & Services

Researchers in rheumatology should avoid categorization of continuous predictor variables

Zubeyir Salis et al.

Summary: This study shows that categorizing continuous predictor variables can alter the results of analysis and potentially lead to different conclusions. Therefore, researchers in rheumatology should avoid this practice.

BMC MEDICAL RESEARCH METHODOLOGY (2023)

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Article Orthopedics

Associations between weight change, knee subcutaneous fat and cartilage thickness in overweight and obese individuals: 4-Year data from the osteoarthritis initiative

Gabby B. Joseph et al.

Summary: Weight change was found to be associated with joint-adjacent SCF but not with changes in cartilage thickness. However, increases in joint-adjacent SCF over 4 years were significantly associated with decreases in cartilage thickness independent of baseline BMI and weight change group.

OSTEOARTHRITIS AND CARTILAGE (2023)

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Article Rheumatology

Multivariable Modeling of Biomarker Data From the Phase I Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium

David J. Hunter et al.

Summary: This study identifies the optimal combination of imaging and biochemical biomarkers for predicting knee osteoarthritis progression. These biomarkers have the potential to be used in future disease-modifying trials to select participants likely to experience progression of knee OA.

ARTHRITIS CARE & RESEARCH (2022)

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Review Orthopedics

Metformin as a potential disease-modifying drug in osteoarthritis: a systematic review of pre-clinical and human studies

Y. Z. Lim et al.

Summary: Objective: This study systematically reviewed the potential disease-modifying effect of metformin in osteoarthritis based on evidence from pre-clinical and human studies. The results suggest that metformin has chondroprotective, immunomodulatory, and analgesic effects in osteoarthritis, supported by consistent findings in pre-clinical and human studies. Further high-quality clinical trials are needed to confirm these findings.

OSTEOARTHRITIS AND CARTILAGE (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Joint-adjacent Adipose Tissue by MRI is Associated With Prevalence and Progression of Knee Degenerative Changes: Data from the Osteoarthritis Initiative

Jannis Bodden et al.

Summary: The study revealed significant associations between joint-adjacent subcutaneous fat (SCF) thickness and imaging parameters of knee osteoarthritis, indicating a potential role of SCF in the development and progression of knee osteoarthritis. Thigh SCF, however, showed no significant associations with knee osteoarthritis, suggesting a spatial relationship between SCF and the disease.

JOURNAL OF MAGNETIC RESONANCE IMAGING (2021)

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Review Orthopedics