Photocatalytic Multicomponent 1,n-Carboimination with Alkyl Iodides and O-Benzoyl Oxime through EnT and XAT Processes

Inthis study, we developed a strategy using commercially availablealkyl iodides and O-benzoyl oxime to efficientlyintroduce alkyl and iminyl groups via energy transfer and halogen-atomtransfer processes. We performed three-component 1,2-carboiminationof olefins and four-component 1,4-carboimination across olefins andalkynes, resulting in the synthesis of over 60 nitrogen-containingmolecules. Moreover, this transformation enables the synthesis ofmolecules with sensitive groups that were previously difficult toachieve.

Automated summary

In this study, a strategy was developed using commercially available alkyl iodides and O-benzoyl oxime to efficiently introduce alkyl and iminyl groups via energy transfer and halogen-atom transfer processes. Three-component 1,2-carboimination of olefins and four-component 1,4-carboimination across olefins and alkynes were performed, resulting in the synthesis of over 60 nitrogen-containing molecules. Moreover, this transformation enables the synthesis of molecules with sensitive groups that were previously difficult to achieve.