期刊
ORGANIC LETTERS
卷 25, 期 40, 页码 7369-7373出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.3c02871
关键词
-
This study presents a method for the synthesis of alkynamides through the cross-coupling of carbamoyl fluorides and alkynylsilanes catalyzed by tetrabutylammonium fluoride (TBAF). It achieves C-F bond cleavage under mild conditions without the need for strongly nucleophilic reagents and/or catalysts, offering advantages over transition-metal-catalyzed approaches in terms of tolerance to aryl halide moieties and complementary chemoselectivity.
We report the synthesis of alkynamides via the cross-coupling of carbamoyl fluorides and alkynylsilanes catalyzed by tetrabutylammonium fluoride (TBAF). In contrast to previously reported transformations of carbamoyl fluorides, C-F bond cleavage is achieved under exceptionally mild conditions (room temperature, low catalyst loadings, and short reaction times) without the need for strongly nucleophilic reagents and/or catalysts. This method offers distinct advantages over transition-metal-catalyzed approaches, such as tolerance to aryl halide moieties and complementary chemoselectivity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据