This study reports an extremely mild method for the direct, transition-metal-free esterification of thioamides through the selective generation of tetrahedral intermediates. It represents the first transition-metal-free approach to the thioamide to thionoester transformation in organic synthesis. The ground-state destabilization of single-atom bioisosteric thioamides will expand the arsenal of valuable amide bond functionalization reactions.
Herein, we report an exceedingly mild method for thedirect, transition-metal-freeesterification of thioamides through the selective generation of tetrahedralintermediates. The method represents the first transition-metal-freeapproach to the thioamide to thionoester transformation in organicsynthesis. This reactivity has been accomplished through N,N-Boc(2)-thioamides that engage in ground-state destabilizationof the n(N) & RARR; & pi;*(C S) conjugation.The ground-state destabilization of single-atom bioisostericthioamides will expand the arsenal of valuable amide bond functionalizationreactions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据