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卷 25, 期 36, 页码 6773-6778出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.3c02770
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A visible-light-driven desaturative beta-alkoxyoxalyation reaction has been reported. The reaction proceeds under mild conditions and does not require a photocatalyst or transition metal. The C-Br bond undergoes homolysis to produce a difluoroalkyl radical, which then undergoes defluorinated beta-alkoxyoxalylation cascades to yield a wide range of beta-ketoester/ketoamide substituted enamines. The oxygen source for the carbonyl unit is confirmed to be H2O through O-18 labeling experiments.
A visible-light-driven desaturative beta-alkoxyoxalyation of N-aryl cyclic amines with difluoromethyl bromides and H2O has been reported. This tandem reaction is triggered by homolysis of the C-Br bond to produce the difuoroalkyl radical, which undergoes the subsequent defluorinated beta-alkoxyoxalylation cascades to afford a wide range of beta-ketoester/ketoamides substituted enamines. The prominent feature of this reaction contains photocatalyst-free, transition-metal free, and mild conditions. The O-18 labeling experiment disclosed that H2O is the oxygen source of the carbonyl unit.
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