Atroposelective Synthesis of N-N Axially Chiral Bipyrroles via Rhodium-Catalyzed C-H Insertion Reaction

An atroposelective synthesis of bipyrroleswith an axially chiralN-N bond has been established via a rhodium-catalyzed C-Hbond insertion reaction to provide the desired atropisomers in goodyields (up to 97% yield) with good to excellent enantioselectivities(up to 99% ee).

Automated summary

An efficient method for the synthesis of bipyrroles with an axially chiral N-N bond has been developed using a rhodium-catalyzed C-H bond insertion reaction. The desired atropisomers were obtained in high yields (up to 97%) and with excellent enantioselectivities (up to 99% ee).