A straightforward approach for the asymmetric synthesis of multifunctionalized β-lactams has been developed, demonstrating advantages of ready substrate availability, broad applicability, high efficiency, and excellent stereoselectivity.
A straightforward approach for the asymmetric synthesis of multifunctionalized ?-lactams, including those bearing two tetrasubstituted stereogenic centers, has been developed through a palladium-catalyzed vinylogous addition/allylic amination process between 1,3-dienes and a-ketoamides. This protocol features advantages of ready substrate availability, broad applicability, high efficiency, and excellent stereoselectivity, making it an attractive complementary tool to the previous strategies.
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