期刊
ORGANIC LETTERS
卷 25, 期 27, 页码 5078-5083出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.3c01788
关键词
-
Regio- and chemoselective amidation of benzocyclobutenols has been achieved using dioxazolone as the amidating reagent and cobalt(III) or rhodium(III) catalysts. The cobalt(III)-catalyzed coupling first forms an isolable o-(N-acylamino)arylmethyl ketone, which can further cyclize to indole derivatives. In contrast, efficient stepwise diamidation is achieved under rhodium(III) catalyst control. The chemoselectivity is controlled by the catalyst and reaction conditions.
Cobalt(III)and rhodium(III)-catalyzed regio- and chemoselectiveamidation of benzocyclobutenols has been realized using dioxazoloneas the amidating reagent to afford three classes of C-N-coupledproducts via & beta;-carbon elimination of the benzocyclobutenol.The Co(III)-catalyzed coupling initially afforded an isolable o-(N-acylamino)arylmethyl ketone, whichcould further cyclize to the corresponding indole derivatives undercondition control. In contrast, efficient stepwise diamidation hasbeen achieved under Rh(III) catalyst control. The chemoselectivitiesare jointly controlled by the catalyst and reactions conditions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据