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ORGANIC LETTERS
卷 25, 期 31, 页码 5756-5761出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.3c01973
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A nickel-catalyzed regioselective cross-electrophilic ring opening reaction of sulfonyl-protected aziridines with trifluoromethyl-substituted alkenes has been reported, providing a new and efficient entry to prepare gem-difluorobishomoallylic sulfonamides. Moreover, the scaffold of 6-fluoro-1,2,3,4-tetrahydropyridine can be constructed starting from the ring opening products via NaH-mediated intramolecular defluorinative nucleophilic vinylic substitution.
Hereinwe report a nickel-catalyzed regioselective cross-electrophilering opening reaction of sulfonyl-protected aziridines with trifluoromethyl-substitutedalkenes as the gem-difluoroallylating agents, providinga new and efficient entry to prepare gem-difluorobishomoallylicsulfonamides. Moreover, the scaffold of 6-fluoro-1,2,3,4-tetrahydropyridinecan be constructed starting from the ring opening products via NaH-mediatedintramolecular defluorinative nucleophilic vinylic substitution.
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