期刊
ORAL DISEASES
卷 -, 期 -, 页码 -出版社
WILEY
DOI: 10.1111/odi.14739
关键词
alveolar bone loss; cytokine; periodontitis; probiotics; X-ray microtomography
This study found that Lactobacillus fermentum BELF11 can inhibit alveolar bone loss and the progression of periodontitis by regulating the production of pro-inflammatory cytokines. This suggests that Lactobacillus fermentum BELF11 may be a potential adjunctive therapy in periodontal treatment.
ObjectiveThis study investigated the effects of Lactobacillus fermentum BELF11 on periodontitis in mice (LIP).MethodsSixty mice were randomly assigned to a control group (CTL), LIP/PBS group (LIP and PBS applied), or LIP/BELF11 group (LIP and L. fermentum BELF11 applied). For 14 days, PBS or L. fermentum BELF11 was applied twice daily to the mice in the LIP/PBS or LIP/BELF11 group, respectively. After 14 days, radiographic, histological, and pro-inflammatory cytokine assessments were conducted.ResultsThe LIP/PBS and LIP/BELF11 groups demonstrated greater alveolar bone loss than the CTL group (p < 0.05). The LIP/BELF11 group showed significantly reduced alveolar bone loss on the mesial side compared to the LIP/PBS group. Histologically, the LIP/BELF11 group showed consistent patterns of connective tissue fiber arrangement, lower levels of inflammatory infiltration, less alveolar bone loss, and higher alveolar bone density than the LIP/PBS group, despite showing more signs of destruction than the CTL group. The LIP/BELF11 group also exhibited significantly lower levels of pro-inflammatory cytokines than the LIP/PBS group.ConclusionsL. fermentum BELF11 inhibits alveolar bone loss and periodontitis progression by regulating pro-inflammatory cytokine production. These findings suggest that L. fermentum BELF11 may be a potential adjunctive therapy in periodontal treatment.
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