4.5 Review

Potassium channels as novel molecular targets in hepatocellular carcinoma (Review)

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Sodium Pump Na plus /K plus ATPase Subunit α1-Targeted Positron Emission Tomography Imaging of Hepatocellular Carcinoma in Mouse Models

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Summary: NKA alpha 1 emerges as a potential diagnostic biomarker for HCC with high expression in early stages and potential correlation with poor survival. PET tracer F-18-ALF-NOTA-S3 shows great potential for detecting small HCC lesions.

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Summary: This study investigates the role of TREK1 channels in hepatic stellate cells (HSCs) and their impact on membrane potential, calcium concentration, extracellular matrix production, and cell proliferation. The findings suggest that TREK1 channels play a crucial role in the molecular mechanism underlying hepatic fibrosis and may serve as a potential therapeutic target.

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Tumor-Suppressor Role of the α1-Na/K-ATPase Signalosome in NASH Related Hepatocellular Carcinoma

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Summary: Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide, with non-alcoholic steatohepatitis (NASH) becoming the major cause in Western countries due to the obesity epidemic. The molecular mechanisms underlying the progression of NASH to HCC are largely unknown. The study suggests that the alpha 1-Na/K-ATPase (NKA)/Src signalosome, which affects cell redox status and apoptotic activity, may play a role in the development of HCC from NASH and could be a potential target for clinical therapy.

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KCNN4 Promotes the Stemness Potentials of Liver Cancer Stem Cells by Enhancing Glucose Metabolism

Jing Fan et al.

Summary: In this study, we found that KCNN4 channel protein promotes the stemness of liver cancer stem cells (LCSCs) by enhancing glucose metabolism, and it may serve as a potential molecular target for eliminating LCSCs in hepatocellular carcinoma (HCC).

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Potassium Channels as a Target for Cancer Therapy: Current Perspectives

Leandro Zuniga et al.

Summary: This article summarizes the important role of potassium channels in cancer, including promoting cell proliferation, resistance to apoptosis, metabolic changes, angiogenesis, and migratory capabilities, and discusses strategies for designing new drugs.

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Review Gastroenterology & Hepatology

Epidemiology of Hepatocellular Carcinoma

Katherine A. McGlynn et al.

Summary: Liver cancer, particularly hepatocellular carcinoma (HCC), is a major global health concern. While HBV and HCV remain important risk factors for HCC, efforts in vaccination and treatment are showing promise. However, the increasing prevalence of metabolic risk factors like obesity and diabetes, as well as other factors like excessive alcohol consumption, present ongoing challenges in the prevention of liver cancer.

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EAG1 enhances hepatocellular carcinoma proliferation by modulating SKP2 and metastasis through pseudopod formation

Jun Chen et al.

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Targeting Na+/K+-ATPase by berbamine and ouabain synergizes with sorafenib to inhibit hepatocellular carcinoma

Songpeng Yang et al.

Summary: Berbamine and ouabain synergize with sorafenib to inhibit hepatocellular carcinoma cells growth by activating p38MAPK and EGFR-ERK pathways. The combination of sorafenib with berbamine or ouabain synergistically inhibits both sorafenib-naive and sorafenib-resistant hepatocellular carcinoma cells growth, induces cell death, and significantly inhibits hepatocellular carcinoma xenografts growth in vivo. Targeting Na+/K+-ATPase represents a novel strategy to potentiate the anti-hepatocellular carcinoma effects of sorafenib.

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Role for calcium-activated potassium channels (BK) in migration control of human hepatocellular carcinoma cells

Yuan He et al.

Summary: Hepatocellular carcinoma (HCC) is a major cause of cancer-related death globally, with research indicating that large-conductance calcium-activated potassium channels (BK channels) play a significant role in the migration of HCC cells, particularly under hypoxic conditions.

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Junda Liu et al.

Summary: Liver macrophages play a crucial role in liver inflammation and injury, forming an interaction network with other liver cells which impacts the development of liver diseases. Research suggests that Kv1.3 potassium channels are closely related to immune cell function, providing a potential therapeutic target for liver diseases.

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KCNN4 promotes invasion and metastasis through the MAPK/ERK pathway in hepatocellular carcinoma

Qiu-Ting Li et al.

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Joining the dots for better liver cancer treatment

Lo-Kong Chan et al.

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Tumour evolution in hepatocellular carcinoma

Amanda J. Craig et al.

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Procyanidin B1, a novel and specific inhibitor of Kv10.1 channel, suppresses the evolution of hepatoma

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Effect of lncRNA KCNQ1OT1 on autophagy and drug resistance of hepatocellular carcinoma cells by targeting miR-338-3p

Weiwei Zhong et al.

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A global view of hepatocellular carcinoma: trends, risk, prevention and management

Ju Dong Yang et al.

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Voltage-Gated Potassium Channel Kv1.3 as a Target in Therapy of Cancer

Andrzej Teisseyre et al.

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ALKBH5 Inhibits Pancreatic Cancer Motility by Decreasing Long Non-Coding RNA KCNK15-AS1 Methylation

Yuan He et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

Review Gastroenterology & Hepatology

Risk factors and prevention of hepatocellular carcinoma in the era of precision medicine

Naoto Fujiwara et al.

JOURNAL OF HEPATOLOGY (2018)

Review Physiology

ION CHANNELS IN CANCER: ARE CANCER HALLMARKS ONCOCHANNELOPATHIES?

Natalia Prevarskaya et al.

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Hypermethylated KCNQ1 acts as a tumor suppressor in hepatocellular carcinoma

Haiyan Fan et al.

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Molecular therapies and precision medicine for hepatocellular carcinoma

Josep M. Llovet et al.

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Liver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis

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Eag1 Voltage-Dependent Potassium Channels: Structure, Electrophysiological Characteristics, and Function in Cancer

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Liver capsule: Molecular-based signatures in hepatocellular carcinoma

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Linda Sevelsted Moller et al.

SCIENTIFIC REPORTS (2016)

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Proapoptotic Role of Potassium Ions in Liver Cells

Zhenglin Xia et al.

BIOMED RESEARCH INTERNATIONAL (2016)

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Ion Channels in Development and Cancer

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Ion Channels in Innate and Adaptive Immunity

Stefan Feske et al.

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Involvement of potassium channels in the progression of cancer to a more malignant phenotype

Nuria Comes et al.

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Targeting ion channels for cancer therapy by repurposing the approved drugs

Vijay Pralhad Kale et al.

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Structure of potassium channels

Qie Kuang et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2015)

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Targeting Na+/K+-translocating adenosine triphosphatase in cancer treatment

Cameron T. Durlacher et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2015)

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Differential Expression of Ion Channels and Transporters During Hepatocellular Carcinoma Development

Violeta Zuniga-Garcia et al.

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Epigenetic dysregulation of KCa3.1 channels induces poor prognosis in lung cancer

Etmar Bulk et al.

INTERNATIONAL JOURNAL OF CANCER (2015)

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Voltage-Gated Potassium Channels Kv1.3-Potentially New Molecular Target in Cancer Diagnostics and Therapy

Andrzej Teisseyre et al.

ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE (2015)

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Na+/K+ ATPase Inhibitors in Cancer

Konstantinos Alevizopoulos et al.

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Hepatocellular carcinoma: clinical frontiers and perspectives

Jordi Bruix et al.

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Targeting potassium channels in cancer

Xi Huang et al.

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TRPM2 channels mediate acetaminophen-induced liver damage

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FXYD6: a novel therapeutic target toward hepatocellular carcinoma

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The roles of K+ channels in cancer

Luis A. Pardo et al.

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A Novel Tetranucleotide Repeat Polymorphism Within KCNQ1OT1 Confers Risk for Hepatocellular Carcinoma

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The voltage-dependent K+ channels Kv1.3 and Kv1.5 in human cancer

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Eag1 Channels as Potential Cancer Biomarkers

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The Two-Pore Domain Potassium Channel KCNK5: Induction by Estrogen Receptor α and Role in Proliferation of Breast Cancer Cells

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Ion channels and the hallmarks of cancer

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The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans

Kazuyoshi Toyama et al.

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Ion channels and cancer

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Roles of K+ channels in regulating tumour cell proliferation and apoptosis

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