The versatile roles of lumican in eye diseases: A review

Lumican is a keratan sulfate proteoglycan that belongs to the small leucine-rich proteoglycan family. Research has lifted the veil on the versatile roles of lumican in the pathogenesis of eye diseases. Lumican has pivotal roles in the maintenance of physiological tissue homogenesis and is often upregulated in pathological conditions, e.g., fibrosis, scar tissue formation in injured tissues, persistent inflammatory responses and immune anomaly, etc.Herein, we will review literature regarding the role of lumican in pathogenesis of inherited congenital and acquired eye diseases, e.g., cornea dystrophy, cataract, glaucoma and chorioretinal diseases, etc.

Automated summary

Lumican, a keratan sulfate proteoglycan, plays versatile roles in the pathogenesis of eye diseases. It is involved in the maintenance of tissue homogeneity and shows upregulation in pathological conditions such as fibrosis, scar tissue formation, inflammatory responses, and immune anomaly. This review focuses on the role of lumican in the pathogenesis of inherited congenital and acquired eye diseases such as cornea dystrophy, cataract, glaucoma, and chorioretinal diseases.