Etiology, Risk Factors, and Management of Asherman Syndrome

Asherman syndrome is characterized by a triad of symptoms including pain, menstrual abnormalities, and infertility and is a result of intrauterine scar tissue after instrumentation of a gravid uterus. Saline sonohysterogram is typically the most sensitive diagnostic tool; however, hysteroscopy is the criterion standard for diagnosis. Treatment includes hysteroscopic-guided lysis of adhesion, with restoration of the anatomy of the uterine cavity. Several modalities are used in an attempt to reduce the reformation of scar tissue after surgery; however, there is no consensus on the ideal method. Stem cells and platelet-rich plasma are being explored as means of regenerative therapy for the endometrium, but data remain limited. At present, most individuals can have restoration of menstrual function; however, lower pregnancy rates and obstetric complications are not uncommon. These complications are worse for patients with a higher grade of disease. Efforts are needed in standardizing classification, reducing uterine instrumentation of the gravid uterus, and referring patients to health care professionals with clinical expertise in this area.

Automated summary

Asherman syndrome is a condition characterized by pain, menstrual abnormalities, and infertility, resulting from intrauterine scar tissue after surgery. Hysteroscopy is the preferred method for diagnosis and treatment usually involves hysteroscopic-guided lysis of adhesions. Various methods are being explored to reduce the reformation of scar tissue after surgery, including the use of stem cells and platelet-rich plasma for regenerative therapy.