Multifaceted roles of T cells in obesity and obesity-related complications: A narrative review

Obesity is characterized by chronic low-grade inflammatory responses in the adipose tissue, accompanied by pronounced insulin resistance and metabolic anomalies. It affects almost all body organs and eventually leads to diseases such as fatty liver disease, type 2 diabetes mellitus, and atherosclerosis. Recently, T cells have emerged as interesting therapeutic targets because the dysfunction of T cells and their cytokines in the adipose tissue is implicated in obesity-induced inflammation and their complicated onset. Although several recent narrative reviews have provided a brief overview of related evidence in this area, they have mainly focused on either obesity-associated T cell metabolism or modulation of T cell activation in obesity. Moreover, at present, no published review has reported on the multifaceted roles of T cells in obesity and obesity-related complications, even though there has been a significant increase in studies on this topic since 2019. Therefore, this narrative review aims to comprehensively summarize current advances in the mechanistic roles of T cells in the development of obesity and its related complications. Further, we aim to discuss relevant drugs for weight loss as well as the contradictory role of T cells in the same disease so as to highlight key findings regarding this topic and provide a valid basis for future treatment strategies.

Automated summary

Obesity is characterized by chronic low-grade inflammation, insulin resistance, and metabolic anomalies, leading to diseases such as fatty liver disease, type 2 diabetes mellitus, and atherosclerosis. T cells have emerged as therapeutic targets due to their involvement in obesity-induced inflammation. However, there is a lack of comprehensive reviews on the multifaceted roles of T cells in obesity and its related complications. This narrative review aims to summarize current advances in understanding the mechanistic roles of T cells in obesity and provide insights for future treatment strategies.