Dietary approaches for controlling cancer by limiting the Warburg effect: a review

Cancer is a mysterious disease. Among other alterations, tumor cells, importantly, have metabolic modifications. A well-known metabolic modification commonly observed in cancer cells has been termed the Warburg effect. This phenomenon is defined as a high preference for glucose uptake, and increased lactate production from that glucose, even when oxygen is readily available. Some anti-cancer drugs target the proposed Warburg effect, and some dietary regimens can function similarly. However, the most suitable dietary strategies for treating particular cancers are not yet well understood. The aim of this review was to describe findings regarding the impact of various proposed dietary regimens targeting the Warburg effect. The evidence suggests that combining routine cancer therapies with diet-based strategies may improve the outcome in treating cancer. However, designing individualized therapies must be our ultimate goal.

Automated summary

This review describes the impact of various dietary regimens targeting the Warburg effect on cancer treatment. The evidence suggests that combining diet-based strategies with routine cancer therapies may improve treatment outcomes, but the most suitable dietary strategies for specific cancers are not well understood yet.