4.8 Article

Domain acquisition by class I aminoacyl-tRNA synthetase urzymes coordinated the catalytic functions of HVGH and KMSKS motifs

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

A Leucyl-tRNA Synthetase Urzyme: Authenticity of tRNA Synthetase Catalytic Activities and Promiscuous Phosphorylation of Leucyl-5′ AMP

Jessica J. Hobson et al.

Summary: Aminoacyl-tRNA synthetases (aaRS)/tRNA pairs play a crucial role in translating the genetic code. The study of urzymes, which are experimental models for the early evolution of aaRS, has provided insights into their catalytic activities. In this study, a new urzyme (LeuAC) was described and shown to catalyze both amino acid activation and tRNA aminoacylation. Additionally, LeuAC was found to have a non-canonical enzymatic function of producing ADP.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Biology

Amino acid activation analysis of primitive aminoacyl-tRNA synthetases encoded by both strands of a single gene using the malachite green assay

Kazaha Onodera et al.

Summary: The Rodin-Ohno hypothesis suggests that two classes of aminoacyl-tRNA synthetases were encoded complementary to double-stranded DNA. Experimental analysis using peptides derived from the structures of TrpRS and HisRS supports this hypothesis, but also indicates the need for unique evolutionary models to be established.

BIOSYSTEMS (2021)

Review Biochemistry & Molecular Biology

The Roots of Genetic Coding in Aminoacyl-tRNA Synthetase Duality

Charles W. Carter et al.

Summary: Codon-dependent translation is crucial for genetics and phylogenetic inferences, but its origins present two challenges in terms of the enforcement of rules by aminoacyl-tRNA synthetases (aaRSs) and the formation of specific assignments. Experimental deconstruction of aaRS superfamilies has provided new tools for understanding the emergence of the genetic code.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 90, 2021 (2021)

Review Biochemistry & Molecular Biology

Aminoacyl-tRNA synthetases

Miguel Angel Rubio Gomez et al.

Article Chemistry, Physical

A modified PATH algorithm rapidly generates transition states comparable to those found by other well established algorithms

Srinivas Niranj Chandrasekaran et al.

STRUCTURAL DYNAMICS-US (2016)

Article Biochemistry & Molecular Biology

Functional Class I and II Amino Acid-activating Enzymes Can Be Coded by Opposite Strands of the Same Gene

Luis Martinez-Rodriguez et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Review Biochemistry & Molecular Biology

Urzymology: Experimental Access to a Key Transition in the Appearance of Enzymes

Charles W. Carter

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Review Chemistry, Multidisciplinary

New insights into prebiotic chemistry from Stanley Miller's spark discharge experiments

Jeffrey L. Bada

CHEMICAL SOCIETY REVIEWS (2013)

Article Biochemistry & Molecular Biology

Aminoacylating Urzymes Challenge the RNA World Hypothesis

Li Li et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

Full Implementation of the Genetic Code by Tryptophanyl-tRNA Synthetase Requires Intermodular Coupling

Li Li et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Biochemical Research Methods

NIH Image to ImageJ: 25 years of image analysis

Caroline A. Schneider et al.

NATURE METHODS (2012)

Review Biochemistry & Molecular Biology

The interface of protein structure, protein biophysics, and molecular evolution

David A. Liberles et al.

PROTEIN SCIENCE (2012)

Article Multidisciplinary Sciences

An epistatic ratchet constrains the direction of glucocorticoid receptor evolution

Jamie T. Bridgham et al.

NATURE (2009)

Article Biochemistry & Molecular Biology

The CP2 Domain of Leucyl-tRNA Synthetase Is Crucial for Amino Acid Activation and Post-transfer Editing

Xiao-Long Zhou et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Biochemical Research Methods

Methods for kinetic and thermodynamic analysis of aminoacyl-tRNA synthetases

Christopher S. Francklyn et al.

METHODS (2008)

Article Multidisciplinary Sciences

Crystal structure of an ancient protein: Evolution by conformational epistasis

Eric A. Ortlund et al.

SCIENCE (2007)

Article Biochemistry & Molecular Biology

Using molecular dynamics to map interaction networks in an aminoacyl-tRNA synthetase

Michael E. Budiman et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2007)

Article Multidisciplinary Sciences

Evolution of hormone-receptor complexity by molecular exploitation

JT Bridgham et al.

SCIENCE (2006)

Review Biochemistry & Molecular Biology

Coevolution theory of the genetic code at age thirty

JTF Wong

BIOESSAYS (2005)

Review Genetics & Heredity

Resurrecting ancient genes: experimental analysis of extinct molecules

JW Thornton

NATURE REVIEWS GENETICS (2004)

Article Biochemistry & Molecular Biology

Functional convergence of two lysyl-tRNA synthetases with unrelated topologies

T Terada et al.

NATURE STRUCTURAL BIOLOGY (2002)

Article Biochemistry & Molecular Biology

Four-body potentials reveal protein-specific correlations to stability changes caused by hydrophobic core mutations

CW Carter et al.

JOURNAL OF MOLECULAR BIOLOGY (2001)