期刊
MOLECULAR PHARMACEUTICS
卷 13, 期 12, 页码 4231-4235出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.molpharmaceut.6b00747
关键词
polysaccharide; prodrug; self-targetability; orthotopic hepatoma; chemotherapy
资金
- National Natural Science Foundation of China [51303174, 51390484, 51321062, 51473165]
- National Institutes of Health [NCI R01CA175480]
Self-targetability is an emerging targeting strategy for polymer nanocarriers with facile preparation and high targeting efficiency. An acid-sensitive dextran doxorubicin prodrug (Dex-g-DOX) has been synthesized and used as a self-targeted drug delivery system for the treatment of orthotopic hepatoma. The polysaccharide prodrug exhibits ultraselective accumulation in cancerous liver tissue, acid-sensitive DOX release within cells, and high antitumor efficacy in vitro and in vivo. Therefore, Dex-g-DOX demonstrates great potential for chemotherapy of orthotopic hepatoma.
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