期刊
MOLECULAR PAIN
卷 12, 期 -, 页码 -出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1744806916647056
关键词
Autism; pain; shank2; nociception
资金
- National Research Foundation (NRF) of Korea grant - Korean government (MSIP) [NRF-2012R1A3A1050385, 35B-2011-1-C00034]
- Canada Research Chair, Canadian Institute for Health Research operating Grants [MOP-124807]
- NSERC Discovery Grant [RGPIN 402555]
- Ontario-China Research and Innovation Fund
- National Research Foundation of Korea [35B-2011-1-C00034] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Autism spectrum disorder is a debilitating mental illness and social issue. Autism spectrum disorder patients suffer from social isolation, cognitive deficits, compulsive behavior, and sensory deficits, including hyposensitivity to pain. However, recent studies argued that autism spectrum disorder patients show physiological pain response and, in some cases, even extremely intense pain response to harmless stimulation. Recently, Shank gene family was reported as one of the genetic risk factors of autism spectrum disorder. Thus, in this study, we used Shank2(-/-) (Shank2 knock-out, KO) mice to investigate the controversial pain sensitivity issue and found that Shank2 KO mice showed reduced tactile perception and analgesia to chronic pain.
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