Neural correlates of social interaction anxiety and their relation to emotional intelligence: A resting-state fMRI study

Social interaction anxiety refers to a state of anxiety resulting from the prospect or presence of interpersonal evaluation in real or imagined social settings. Previous neuroimaging studies have revealed neural basis of social anxiety disorder. However, little is known about the neural correlates of individual differences in social interaction anxiety in nonclinical population. In the present study, we used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety, and the role that emotional intelligence played in the relationship. To this end, the correlation between the regional fractional amplitude of low-frequency fluctuations (fALFF) of the brain and individuals' social interaction anxiety scores was examined. We found that social interaction anxiety was correlated with the fALFF in the insula, parahippocampal gyrus, bilateral superior temporal gyrus, and superior parietal lobule. Furthermore, we also found that emotional intelligence partially mediated the association between the fALFF in these regions and social interaction anxiety. Taken together, our study provided the first evidence for the spontaneous neural basis of social interaction anxiety in normal population, and highlighted the neural substrates through which emotional intelligence might play an important role in social interaction anxiety.

Automated summary

This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.