Are novel treatments for brain disorders hiding in plain sight?

Article Psychology, Clinical

Shared genetic influences on depression and menopause symptoms

Joeri J. Meijsen et al.

Summary: This study found shared genetic influences between menopause symptoms and depression, and identified a gene associated with menopause symptoms. This finding has direct clinical relevance for the treatment of hot flashes.

PSYCHOLOGICAL MEDICINE (2023)

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Review Genetics & Heredity

15 years of GWAS discovery: Realizing the promise

Abdel Abdellaoui et al.

Summary: The GWAS era has led to significant discoveries in various fields, including population genetics, complex trait genetics, epidemiology, social science, and medicine. The emergence of large-scale biobanks and whole-genome sequencing will further enhance our understanding of human genetic variation and its implications for complex traits and diseases.

AMERICAN JOURNAL OF HUMAN GENETICS (2023)

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Article Multidisciplinary Sciences

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Vassily Trubetskoy et al.

Summary: In this study, a two-stage genome-wide association study was conducted to identify common variants associated with schizophrenia. The results revealed 287 distinct genomic loci and 120 genes likely to be involved in the development of schizophrenia. This research provides valuable insights into the pathophysiology of schizophrenia and offers a resource for further mechanistic studies.

NATURE (2022)

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Article Multidisciplinary Sciences

Genetic diversity fuels gene discovery for tobacco and alcohol use

Gretchen R. B. Saunders et al.

Summary: This study utilized global genetic diversity data to discover and fine-map genomic loci associated with tobacco and alcohol use. Ancestry-aware transcriptome-wide association studies were conducted to understand the function of these loci. The study also evaluated the genetic architecture and predictive power of polygenic risk in different populations. The results demonstrated that increasing sample size and genetic diversity improved the identification and fine-mapping of loci, but polygenic risk scores performed poorly across different ancestries.

NATURE (2022)

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News Item Biotechnology & Applied Microbiology

REGULATORY WATCH Human genetics evidence supports two-thirds of the 2021 FDA-approved drugs

David Ochoa et al.

NATURE REVIEWS DRUG DISCOVERY (2022)

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Article Substance Abuse

Genomic relationships across psychiatric disorders including substance use disorders

Abdel Abdellaoui et al.

Summary: The study investigated genetic associations and latent genetic structure among psychiatric disorders, finding significant genetic correlations between alcohol and nicotine dependence with other disorders, while cannabis use disorder was only associated with ADHD. Including substance use disorders in the factor analysis led to changes in the underlying genetic factor structure, emphasizing the importance of cautious interpretation of the identified structures.

DRUG AND ALCOHOL DEPENDENCE (2021)

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Article Biology

GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background

Nasa Sinnott-Armstrong et al.

Summary: GWAS are used to study the genetic basis of complex diseases and traits, and UK Biobank GWAS results for molecular traits like urate, IGF-1, and testosterone show easily interpretable hits near genes involved in relevant pathways. These molecular traits are highly polygenic, with thousands of variants contributing to trait variance across the genome.

ELIFE (2021)

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Article Pharmacology & Pharmacy

Effects of neurokinin 3 receptor antagonist fezolinetant on hot flash-like symptoms in ovariectomized rats

Atsuo Tahara et al.

Summary: The study shows that fezolinetant can attenuate hot flash-like symptoms by inhibiting neuronal activity in the median preoptic nucleus of ovariectomized rats, and reduce hyperphagia and weight gain in menopausal rats.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

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Article Obstetrics & Gynecology